Results 51 to 60 of about 8,438 (230)

The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human african trypanosomiasis.

PLoS Neglected Tropical Diseases, 2010
BackgroundTrypanosoma brucei gambiense is the causative agent of chronic Human African Trypanosomiasis or sleeping sickness, a disease endemic across often poor and rural areas of Western and Central Africa.
Andrew P Jackson, Mandy Sanders, Andrew Berry, Jacqueline McQuillan, Martin A Aslett, Michael A Quail, Bridget Chukualim, Paul Capewell, Annette MacLeod, Sara E Melville, Wendy Gibson, J David Barry, Matthew Berriman, Christiane Hertz-Fowler   +13 more
doaj   +1 more source

Structural Studies of Variant Surface Glycoproteins on the Trypanosoma Surface

, 2021
Trypanosoma parasites are the pathogenic agent causing human and animal African Trypanosomiasis. The parasites undergo a process called antigenic variation, which allows them to perpetually evade the host immune response. Trypanosomes are coated almost uniformly with a single protein, the Variant Surface Glycoprotein (VSG).
openaire   +2 more sources

Widespread variation in transcript abundance within and across developmental stages of Trypanosoma brucei

BMC Genomics, 2009
Background Trypanosoma brucei, the causative agent of African sleeping sickness, undergoes a complex developmental cycle that takes place in mammalian and insect hosts and is accompanied by changes in metabolism and cellular morphology. While differences
Kifer Charles T, Sivam Dhileep, Jensen Bryan C, Myler Peter J, Parsons Marilyn   +4 more
doaj   +1 more source

Selection of binding targets in parasites using phage-display and aptamer libraries in vivo and in vitro [PDF]

, 2013
Parasite infections are largely dependent on interactions between pathogen and different host cell populations to guarantee a successful infectious process.
Alves, Maria Julia Manso, Colli, Walter, Tonelli, Renata Rosito   +2 more
core   +2 more sources

Digital gene expression analysis of two life cycle stages of the human-infective parasite, Trypanosoma brucei gambiense reveals differentially expressed clusters of co-regulated genes

BMC Genomics, 2010
Background The evolutionarily ancient parasite, Trypanosoma brucei, is unusual in that the majority of its genes are regulated post-transcriptionally, leading to the suggestion that transcript abundance of most genes does not vary significantly between ...
Wildridge David, Terry Sandra, Trivedi Urmi, Johnson Paul CD, Veitch Nicola J, MacLeod Annette   +5 more
doaj   +1 more source

Turnover of Variant Surface Glycoprotein in Trypanosoma brucei Is Not Altered in Response to Specific Silencing

Msphere, 2022
African trypanosomes evade the host immune system by altering the expression of variant surface glycoproteins (VSGs) in a process called antigenic variation.
Mohamed Sharif, P. Garrison, Peter J Bush, J. Bangs   +3 more
semanticscholar   +1 more source

Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity [PDF]

, 2009
Antigenic variation is an immune evasion strategy that has evolved in viral, bacterial and protistan pathogens. In the African trypanosome this involves stochastic switches in the composition of a variant surface glycoprotein (VSG) coat, using a massive ...
Marcello, Lucio, McCulloch, Richard, Morrison, Liam J.   +2 more
core   +1 more source

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, EarlyView.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

Molecular mechanisms of Trypanosoma cruzi infection by oral route [PDF]

, 2009
Frequent reports on outbreaks of acute Chagas' disease by ingestion of food contaminated with parasites from triatomine insects illustrate the importance of this mode of transmission.
Yoshida, Nobuko
core   +3 more sources

Peroxidase‐Mimicking Nanozymes for Rapid Detection of Infectious Diseases

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Peroxidase‐mimicking nanozymes (PMNs) have emerged as robust and versatile materials for rapid infectious disease diagnostics. This review highlights the rational design and controlled synthesis of PMNs, summarizes key biomarkers relevant to infectious diseases, examines their integration into diverse rapid detection platforms, and highlights ...
Shikuan Shao, Victor Fernandez‐Gonzalez, Xiaochuan Wang, Blake Pylipow, Claudia Herrera, Xiaohu Xia   +5 more
wiley   +1 more source