Results 61 to 70 of about 8,438 (230)

Intracellular colocalization of variant surface glycoprotein and transferrin-gold in Trypanosoma brucei [PDF]

The Journal of cell biology, 1988
Endocytosis and intracellular transport has been studied in the bloodstream forms of Trypanosoma brucei by light and electron microscopy, using colloidal gold coupled to bovine transferrin (transferrin-gold). The endocytosed transferrin-gold, visualized by silver intensification for light microscopy, was present in vesicular structures between the cell
Webster, P., Grab, D.J.
openaire   +2 more sources

Bacterial Extracellular Vesicles in Biomedical Research and Clinical Translation

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
Bacterial membrane vesicle biomedical applications. ABSTRACT Bacterial Extracellular Vesicles (bEVs) are lipid (single‐ or double‐bilayer) nanostructures secreted by virtually all bacteria that play fundamental roles in intercellular communication and have emerged as powerful, multifunctional tools in biomedicine. Their intrinsic ability to encapsulate
Alejandro Arce‐Rodríguez, Javier De la Peña Noya, José Manuel Borrero‐de Acuña   +2 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, Volume 600, Issue 5, Page 591-611, March 2026.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Field observations on the use of rapid diagnostic tests for Human African Trypanosomiasis in Nigeria

Frontiers in Tropical Diseases
IntroductionHuman African Trypanosomiasis (HAT) is a Neglected Tropical Disease targeted for elimination by 2030. Control efforts have reduced prevalence, but diagnostic challenges for field surveillance persist.
Chinwe U. Chukwudi, Chinwe U. Chukwudi, Omolara S. Adenekan, Jonadab C. Chinwendu, Amadea O. Enwonwu, Chinonso C. Iyi, Uchenna H. Anyaorah, Chukwuebuka V. Ugwu, Michael O. John, Glory N. Joseph, Akwoba J. Ogugua, Akwoba J. Ogugua, Silva M. Anika   +12 more
doaj   +1 more source

Trypanosoma brucei gambiense adaptation to different mammalian sera is associated with VSG expression site plasticity.

PLoS ONE, 2013
Trypanosoma brucei gambiense infection is widely considered an anthroponosis, although it has also been found in wild and domestic animals. Thus, fauna could act as reservoir, constraining the elimination of the parasite in hypo-endemic foci.
Carlos Cordon-Obras, Jorge Cano, Dolores González-Pacanowska, Agustin Benito, Miguel Navarro, Jean-Mathieu Bart   +5 more
doaj   +1 more source

Cell-free synthesis of glycosyl-phosphatidylinositol precursors for the glycolipid membrane anchor of Trypanosoma brucei variant surface glycoproteins. Structural characterization of putative biosynthetic intermediates.

Journal of Biological Chemistry, 1990
Trypanosome variant surface glycoproteins exemplify a class of eukaryotic cell surface glycoproteins that rely on a carboxyl-terminal covalently-attached inositol-containing glycophospholipid for membrane attachment.
A. Menon, R. Schwarz, Satyajit Mayor, G. A. Cross   +3 more
semanticscholar   +1 more source

Variant surface glycoprotein gene expression site switches in Trypanosoma brucei.

Journal of Biological Chemistry, 1986
In Trypanosoma brucei bloodstream forms, transcription of variant surface glycoprotein (VSG) genes occurs at only one of several possible expression sites at any given time. Activation and inactivation of some expression sites are correlated with recombinational events that alter their chromosomal position (Van der Ploeg, L. H. T., Cornelissen, A. W. C.
C, Shea, D J, Glass, S, Parangi, L H, Van der Ploeg   +3 more
openaire   +2 more sources

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, Volume 293, Issue 6, Page 1681-1707, March 2026.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Faster growth with shorter antigens can explain a VSG hierarchy during African trypanosome infections:a feint attack by parasites [PDF]

, 2018
The parasitic African trypanosome, Trypanosoma brucei, evades the adaptive host immune response by a process of antigenic variation that involves the clonal switching of variant surface glycoproteins (VSGs).
A Beschin, A Fadda, A Schwede, AP Jackson, C Hertz-Fowler, D Horn, E Gjini, G Caljon, GA Cross, H Fairbairn, HT Timmers, JD Barry, JJ Doyle, JP Hall, K Sheader, KA Lythgoe, L Glover, L Marcello, L Sullivan, M Berriman, M Recker, M Recker, MK Higgins, MR Mugnier, PL Johnson, PT Manna, RL Barnes, S Trindade, SA Frank, SA Frank, WL Dempsey, Z Agur   +31 more
core   +2 more sources

Ultrastructural expansion microscopy reveals unexpected levels of glycosome heterogeneity in African trypanosomes

Journal of Microscopy, Volume 301, Issue 2, Page 222-240, February 2026.
Abstract Kinetoplastid parasites include several species. Trypanosoma brucei causes African sleeping sickness in humans and a wasting disease nagana in livestock. Trypanosoma cruzi is the causative agent of Chagas disease and Leishmania species cause leishmaniasis, which can present with visceral, cutaneous, or mucocutaneous symptoms.
Heidi Anderson, Rhonda Reigers Powell, Meredith Teilhet Morris   +2 more
wiley   +1 more source