Results 21 to 30 of about 8,438 (230)

Infections with extracellular trypanosomes require control by efficient innate immune mechanisms and can result in the destruction of the mammalian humoral immune system [PDF]

, 2020
Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game animals around the world. Through co-evolution with the mammalian immune system, trypanosomes have developed defense mechanisms that allow them to thrive in blood,
Magez, Stefan, Obishakin, Emmanuel Tumininu, Pinto Torres, Joar Esteban, Radwanska, Magdalena   +3 more
core   +1 more source

Comparative Analysis of Virulence Mechanisms of Trypanosomatids Pathogenic to Humans

Frontiers in Cellular and Infection Microbiology, 2021
Trypanosoma brucei, Leishmania spp., and T. cruzi are flagellate protozoans of the family Trypanosomatidae and the causative agents of human African trypanosomiasis, leishmaniasis, and Chagas disease, respectively.
Artur Leonel de Castro Neto, José Franco da Silveira, Renato Arruda Mortara   +2 more
doaj   +1 more source

The Glycan Structure of T. cruzi mucins Depends on the Host. Insights on the Chameleonic Galactose

Molecules, 2020
Trypanosoma cruzi, the protozoa that causes Chagas disease in humans, is transmitted by insects from the Reduviidae family. The parasite has developed the ability to change the structure of the surface molecules, depending on the host.
María Eugenia Giorgi, Rosa M. de Lederkremer   +1 more
doaj   +1 more source

Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models [PDF]

, 2016
Current treatments available for African sleeping sickness or human African trypanosomiasis (HAT) are limited, with poor efficacy and unacceptable safety profiles.
Balzarini, Jan, Castillo Acosta, Víctor M., Etxebarria, Juan, González-Pacanowska, D., Igarashi, Yasuhiro, Liekens, Sandra, Navarro, M., Reichardt, Niels Christian, Ruiz-Pérez, Luis Miguel   +8 more
core   +9 more sources

Myristate exchange on the Trypanosoma brucei variant surface glycoprotein. [PDF]

Proceedings of the National Academy of Sciences, 1996
The glycosyl-phosphatidylinositol (GPI) anchor of the Trypanosoma brucei variant surface glycoprotein (VSG) is unique in having exclusively myristate as its fatty acid component. We previously demonstrated that the myristate specificity is the result of two independent pathways.
L U, Buxbaum, K G, Milne, K A, Werbovetz, P T, Englund   +3 more
openaire   +2 more sources

Genome-Wide Screening for Pathogenic Proteins and microRNAs Associated with Parasite–Host Interactions in Trypanosoma brucei

Insects, 2022
Tsetse flies are a type of blood-sucking insect living in diverse locations in sub-Saharan Africa. These insects can transmit the unicellular parasite Trypanosoma brucei (T. brucei) which causes African trypanosomiasis in mammals. There remain huge unmet
Zhiyuan Yang, Mai Shi, Xiaoli Zhang, Danyu Yao   +3 more
doaj   +1 more source

Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei [PDF]

, 2014
Trypanosoma brucei expresses a diverse repertoire of N-glycans, ranging from oligomannose and paucimannose structures to exceptionally large complex N-glycans.
Acosta-Serrano, Angela Mehlert, Atrih, Bangs, Bangs, Bendiak, Chang, Cross, Cross, Cross, Di Wu, Doering, Ferguson, Ferguson, Giraudo, Grab, Güther, Harpaz, Ho, Hwa, Ioffe, Izquierdo, Izquierdo, Izquierdo, Izquierdo, Izquierdo, Joao A. Rodrigues, Jones, Kornfeld, Leal, Lombard, M.Lucia S. Güther, Manthri, Manuela Damerow, Mazhari-Tabrizi, Mehlert, Mehlert, Mehlert, Mehlert, Mehlert, Metzler, Michael A.J. Ferguson, Milne, Nagamune, Narimatsu, Nolan, Paschinger, Paulson, Pays, Rovis, Schachter, Sonnhammer, Tabas, Tazeh, Urbaniak, Vella, Visser, Wiggins, Wirtz, Wiśniewski, Zamze   +60 more
core   +3 more sources

Glycotyping of Trypanosoma brucei variant surface glycoprotein MITat1.8

Molecular and Biochemical Parasitology, 2010
Following a switch from variant surface glycoprotein MITat1.4 to variant surface glycoprotein MITat1.8 expression by Lister strain 427 Trypanosoma brucei brucei parasites, the latter uncharacterized variant surface glycoprotein was analysed. Variant surface glycoprotein MITat1.8 was found to be a disulphide-linked homodimer, containing a complex N ...
Mehlert, Angela, Sullivan, Lauren, Ferguson, Michael A. J.   +2 more
openaire   +3 more sources

Developmental changes and metabolic reprogramming during establishment of infection and progression of Trypanosoma brucei brucei through its insect host.

PLoS Neglected Tropical Diseases, 2021
Trypanosoma brucei ssp., unicellular parasites causing human and animal trypanosomiasis, are transmitted between mammals by tsetse flies. Periodic changes in variant surface glycoproteins (VSG), which form the parasite coat in the mammal, allow them to ...
Arunasalam Naguleswaran, Paula Fernandes, Shubha Bevkal, Ruth Rehmann, Pamela Nicholson, Isabel Roditi   +5 more
doaj   +1 more source

Distinct, developmental stage-specific activation mechanisms of trypanosome VSG genes [PDF]

, 1990
The metacyclic form of African trypanosomes is the first to express genes for the Variant Surface Glycoprotein (VSG) and it uses an unusually predictable subset of the VSG gene repertoire.
Barry, J D, Graham, S V, Matthews, K R, Shiels, P G   +3 more
core   +1 more source