Results 11 to 20 of about 8,438 (230)

Characterization of Trypanosoma brucei gambiense variant surface glycoprotein LiTat 1.5 [PDF]

Genetics and molecular research : GMR, 2012
At present, all available diagnostic antibody detection tests for Trypanosoma brucei gambiense human African trypanosomiasis are based on predominant variant surface glycoproteins (VSGs), such as VSG LiTat 1.5. During investigations aiming at replacement
Büscher, P., Guisez, Y., Lejon, V., Rogé, S., Van Nieuwenhove, L.   +4 more
core   +4 more sources

Trypanosoma Variant Surface Glycoprotein: A Review

مجلة الانبار للعلوم البيطرية
The glycoprotein surface of the Trypanosoma parasite plays a crucial role in the organism’s biology, as a protective barrier that facility invasion to the host.
Kalef, Dalia Ahmed, Shather, Maulood M
doaj   +2 more sources

Selective cleavage of variant surface glycoproteins from Trypanosoma brucei. [PDF]

Biochemical Journal, 1979
Two conformationally distinct regions were revealed by tryptic cleavage of six undenatured variant surface glycoproteins purified from clones of Trypanosoma brucei. Within 5 min, the native glycoproteins (65,000 mol.wt.) were cleaved, yielding a large N-terminal fragment (48,000-55,000 mol.wt.
J. Johnson, G. Cross
semanticscholar   +3 more sources

The Dual Role of the 16mer Motif Within the 3' Untranslated Region of the Variant Surface Glycoprotein of Trypanosoma brucei. [PDF]

Mol Microbiol
A fully conserved 16mer motif is required in the silent VSG to trigger efficient silencing of the expression site (ES)‐resident VSG and a successful exchange of the VSG coat. ABSTRACT The variant surface glycoprotein (VSG) of African trypanosomes is essential for the survival of bloodstream form parasites.
Bakari-Soale M, Batram C, Zimmermann H, Jones NG, Engstler M.   +4 more
europepmc   +2 more sources

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites. [PDF]

Chemistry
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Monfret O, Liu D, Louis M, Rebei S, Urban D, Bourdreux Y, Mouray E, Grellier P, Doisneau G, Guianvarc'h D.   +9 more
europepmc   +2 more sources

The SPARC complex defines RNAPII promoters in Trypanosoma brucei

eLife, 2022
Kinetoplastids are a highly divergent lineage of eukaryotes with unusual mechanisms for regulating gene expression. We previously surveyed 65 putative chromatin factors in the kinetoplastid Trypanosoma brucei.
Desislava P Staneva, Stefan Bresson, Tatsiana Auchynnikava, Christos Spanos, Juri Rappsilber, A Arockia Jeyaprakash, David Tollervey, Keith R Matthews, Robin C Allshire   +8 more
doaj   +1 more source

Expression of procyclin mRNAs during cyclical transmission of Trypanosoma brucei. [PDF]

PLoS Pathogens, 2005
Trypanosoma brucei, the parasite causing human sleeping sickness, relies on the tsetse fly for its transmission. In the insect, EP and GPEET procyclins are the major surface glycoproteins of procyclic (midgut) forms of the parasite, with GPEET ...
Simon Urwyler, Erik Vassella, Jan Van Den Abbeele, Christina Kunz Renggli, Pat Blundell, J David Barry, Isabel Roditi   +6 more
doaj   +2 more sources

The variant surface glycoproteins of Trypanosoma equiperdum

FEBS Letters, 1983
T. Baltz, G. Duvillier, C. Giroud, C. Richet, D. Baltz, P. Degand   +5 more
exaly   +2 more sources

A DOT1B/Ribonuclease H2 Protein Complex Is Involved in R-Loop Processing, Genomic Integrity, and Antigenic Variation in Trypanosoma brucei

mBio, 2021
The parasite Trypanosoma brucei periodically changes the expression of protective variant surface glycoproteins (VSGs) to evade its host’s immune system in a process known as antigenic variation.
Nicole Eisenhuth, Tim Vellmer, Elisa T. Rauh, Falk Butter, Christian J. Janzen   +4 more
doaj   +1 more source

A histone methyltransferase modulates antigenic variation in African trypanosomes. [PDF]

PLoS Biology, 2008
To evade the host immune system, several pathogens periodically change their cell-surface epitopes. In the African trypanosomes, antigenic variation is achieved by tightly regulating the expression of a multigene family encoding a large repertoire of ...
Luisa M Figueiredo, Christian J Janzen, George A M Cross   +2 more
doaj   +1 more source