A histone methyltransferase modulates antigenic variation in African trypanosomes. [PDF]
PLoS Biology, 2008 To evade the host immune system, several pathogens periodically change their cell-surface epitopes. In the African trypanosomes, antigenic variation is achieved by tightly regulating the expression of a multigene family encoding a large repertoire of ...
Luisa M Figueiredo +2 more
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Identification of sVSG117 as an immunodiagnostic antigen and evaluation of a dual-antigen lateral flow test for the diagnosis of human African trypanosomiasis. [PDF]
PLoS Neglected Tropical Diseases, 2014 The diagnosis of human African trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense relies mainly on the Card Agglutination Test for Trypanosomiasis (CATT). There is no immunodiagnostic for HAT caused by T. b. rhodesiense.
Lauren Sullivan +5 more
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The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human african trypanosomiasis. [PDF]
PLoS Neglected Tropical Diseases, 2010 BackgroundTrypanosoma brucei gambiense is the causative agent of chronic Human African Trypanosomiasis or sleeping sickness, a disease endemic across often poor and rural areas of Western and Central Africa.
Andrew P Jackson +13 more
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Exposure of Trypanosoma brucei to an N-acetylglucosamine-binding lectin induces VSG switching and glycosylation defects resulting in reduced infectivity. [PDF]
PLoS Neglected Tropical Diseases, 2015 Trypanosoma brucei variant surface glycoproteins (VSG) are glycosylated by both paucimannose and oligomannose structures which are involved in the formation of a protective barrier against the immune system.
Víctor M Castillo-Acosta +4 more
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Comparative Analysis of Virulence Mechanisms of Trypanosomatids Pathogenic to Humans
Frontiers in Cellular and Infection Microbiology, 2021 Trypanosoma brucei, Leishmania spp., and T. cruzi are flagellate protozoans of the family Trypanosomatidae and the causative agents of human African trypanosomiasis, leishmaniasis, and Chagas disease, respectively.
Artur Leonel de Castro Neto +2 more
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The Glycan Structure of T. cruzi mucins Depends on the Host. Insights on the Chameleonic Galactose
Molecules, 2020 Trypanosoma cruzi, the protozoa that causes Chagas disease in humans, is transmitted by insects from the Reduviidae family. The parasite has developed the ability to change the structure of the surface molecules, depending on the host.
María Eugenia Giorgi +1 more
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Insects, 2022 Tsetse flies are a type of blood-sucking insect living in diverse locations in sub-Saharan Africa. These insects can transmit the unicellular parasite Trypanosoma brucei (T. brucei) which causes African trypanosomiasis in mammals. There remain huge unmet
Zhiyuan Yang +3 more
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Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4'-epimerase conditional null mutant [PDF]
, 2006 Galactose metabolism is essential for the survival of Trypanosoma brucei, the etiological agent of African sleeping sickness. T. brucei hexose transporters are unable to transport galactose, which is instead obtained through the epimerization of UDP ...
Turnock, Daniel C. +3 more
core +1 more source
PLoS Neglected Tropical Diseases, 2021 Trypanosoma brucei ssp., unicellular parasites causing human and animal trypanosomiasis, are transmitted between mammals by tsetse flies. Periodic changes in variant surface glycoproteins (VSG), which form the parasite coat in the mammal, allow them to ...
Arunasalam Naguleswaran +5 more
doaj +1 more source
Transcript expression analysis of putative Trypanosoma brucei GPI-anchored surface proteins during development in the tsetse and mammalian hosts. [PDF]
PLoS Neglected Tropical Diseases, 2012 Human African Trypanosomiasis is a devastating disease caused by the parasite Trypanosoma brucei. Trypanosomes live extracellularly in both the tsetse fly and the mammal.
Amy F Savage +5 more
doaj +1 more source