SUMOylated SNF2PH promotes variant surface glycoprotein expression in bloodstream trypanosomes [PDF]
EMBO reports, 2019 SUMOylation is a post¿translational modification that positively regulates monoallelic expression of the trypanosome variant surface glycoprotein (VSG).
Alvarez, Vanina E. +10 more
core +13 more sources
Chaperone requirements for biosynthesis of the trypanosome variant surface glycoprotein. [PDF]
PLoS ONE, 2010 Trypanosoma brucei does not respond transcriptionally to several endoplasmic reticulum (ER) stress conditions, including tunicamycin or dithiothreitol, indicating the absence of a conventional unfolded protein response. This suggests divergent mechanisms
Mark C Field +4 more
doaj +5 more sources
Turnover of Variant Surface Glycoprotein in Trypanosoma brucei Is Not Altered in Response to Specific Silencing [PDF]
mSphere, 2022 African trypanosomes evade the immune system of the mammalian host by the antigenic variation of the predominant glycosylphosphatidylinositol (GPI)-anchored surface protein, variant surface glycoprotein (VSG).
Mohamed Sharif +3 more
doaj +2 more sources
Characterization of Trypanosoma brucei gambiense variant surface glycoprotein LiTat 1.5 [PDF]
Genetics and molecular research : GMR, 2012 At present, all available diagnostic antibody detection tests for Trypanosoma brucei gambiense human African trypanosomiasis are based on predominant variant surface glycoproteins (VSGs), such as VSG LiTat 1.5. During investigations aiming at replacement
Büscher, P. +4 more
core +4 more sources
Trypanosoma Variant Surface Glycoprotein: A Review
مجلة الانبار للعلوم البيطريةThe glycoprotein surface of the Trypanosoma parasite plays a crucial role in the organism’s biology, as a protective barrier that facility invasion to the host.
Kalef, Dalia Ahmed, Shather, Maulood M
doaj +2 more sources
VEX1 Influences mVSG Expression During the Transition to Mammalian Infectivity in Trypanosoma brucei
Frontiers in Cell and Developmental Biology, 2022 The Trypanosoma (T) brucei life cycle alternates between the tsetse fly vector and the mammalian host. In the insect, T. brucei undergoes several developmental stages until it reaches the salivary gland and differentiates into the metacyclic form, which ...
Eliane Tihon +6 more
doaj +1 more source
Dual Mutation Events in the Haemagglutinin-Esterase and Fusion Protein from an Infectious Salmon Anaemia Virus HPR0 Genotype Promote Viral Fusion and Activation by an Ubiquitous Host Protease [PDF]
, 2015 Funding: The Scottish Government funded this work, as part of their global budget on aquaculture research. The funder had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer ...
Collet, Bertrand +6 more
core +14 more sources
Evolution of the variant surface glycoprotein family in African trypanosomes [PDF]
Trends in Parasitology, 2022 An intriguing and remarkable feature of African trypanosomes is their antigenic variation system, mediated by the variant surface glycoprotein (VSG) family and fundamental to both immune evasion and disease epidemiology within host populations. Recent studies have revealed that the VSG repertoire has a complex evolutionary history.
Silva Pereira, Sara +2 more
openaire +3 more sources
Stage-Specific COPII-Mediated Cargo Selectivity in African Trypanosomes
mSphere, 2022 A hallmark of eukaryotic cells is the ability to form a secretory pathway connecting many intracellular compartments. In the early secretory pathway, coated protein complex II (COPII)-coated vesicles mediate the anterograde transport of newly synthesized
Mohamed Sharif, James D. Bangs
doaj +1 more source
An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes
Nature Communications, 2022 A Variant Surface Glycoprotein (VSG) coat protects bloodstream form T. brucei. Applying super-resolution microscopy Budzak et al. characterize a set of nuclear bodies, which associate with the active expression site in bloodstream form T.
James Budzak +4 more
doaj +1 more source