Results 21 to 30 of about 113,459 (293)

TIM-1 Augments Cellular Entry of Ebola Virus Species and Mutants, Which Is Blocked by Recombinant TIM-1 Protein

Microbiology Spectrum, 2022
Ebola virus, a member of the Filoviridae family, utilizes the attachment factors on host cells to support its entry and cause severe tissue damage. TIM-1 has been identified as a predominant attachment factor via interaction with phosphatidylserine (PS ...
Min Zhang, Xinwei Wang, Linhan Hu, Yuting Zhang, Hang Zheng, Haiyan Wu, Jing Wang, Longlong Luo, He Xiao, Chunxia Qiao, Xinying Li, Weijin Huang, Youchun Wang, Jiannan Feng, Guojiang Chen   +14 more
doaj   +1 more source

A Short Series of Case Reports of COVID-19 in Immunocompromised Patients

Viruses, 2022
Immunocompromised individuals are at risk of prolonged SARS-CoV-2 infection due to weaker immunity, co-morbidities, and lowered vaccine effectiveness, which may evolve highly mutated variants of SARS-CoV-2.
Mitali Mishra, Aleena Zahra, Lokendra V. Chauhan, Riddhi Thakkar, James Ng, Shreyas Joshi, Eric D. Spitzer, Luis A. Marcos, W. Ian Lipkin, Nischay Mishra   +9 more
doaj   +1 more source

Trypanosoma brucei ATR Links DNA Damage Signaling during Antigenic Variation with Regulation of RNA Polymerase I-Transcribed Surface Antigens

Cell Reports, 2020
Summary: Trypanosoma brucei evades mammalian immunity by using recombination to switch its surface-expressed variant surface glycoprotein (VSG), while ensuring that only one of many subtelomeric multigene VSG expression sites are transcribed at a time ...
Jennifer Ann Black, Kathryn Crouch, Leandro Lemgruber, Craig Lapsley, Nicholas Dickens, Luiz R.O. Tosi, Jeremy C. Mottram, Richard McCulloch   +7 more
doaj   +1 more source

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease. [PDF]

PLoS Genetics, 2018
Paired Immunoglobulin-like Type 2 Receptor Alpha (PILRA) is a cell surface inhibitory receptor that recognizes specific O-glycosylated proteins and is expressed on various innate immune cell types including microglia.
Nisha Rathore, Sree Ranjani Ramani, Homer Pantua, Jian Payandeh, Tushar Bhangale, Arthur Wuster, Manav Kapoor, Yonglian Sun, Sharookh B Kapadia, Lino Gonzalez, Ali A Zarrin, Alison Goate, David V Hansen, Timothy W Behrens, Robert R Graham   +14 more
doaj   +1 more source

Selective cleavage of variant surface glycoproteins from Trypanosoma brucei [PDF]

Biochemical Journal, 1979
Two conformationally distinct regions were revealed by tryptic cleavage of six undenatured variant surface glycoproteins purified from clones of Trypanosoma brucei. Within 5 min, the native glycoproteins (65,000 mol.wt.) were cleaved, yielding a large N-terminal fragment (48,000-55,000 mol.wt.
J G, Johnson, G A, Cross
openaire   +2 more sources

VSGs Expressed during Natural T. b. gambiense Infection Exhibit Extensive Sequence Divergence and a Subspecies-Specific Bias towards Type B N-Terminal Domains

mBio, 2022
Trypanosoma brucei gambiense is the primary causative agent of human African trypanosomiasis (HAT), a vector-borne disease endemic to West and Central Africa.
Jaime So, Sarah Sudlow, Abeer Sayeed, Tanner Grudda, Stijn Deborggraeve, Dieudonné Mumba Ngoyi, Didier Kashiama Desamber, Bill Wickstead, Veerle Lejon, Monica R. Mugnier   +9 more
doaj   +1 more source

Beyond immune escape:a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei [PDF]

, 2017
Suramin is one of the first drugs developed in a medicinal chemistry program (Bayer, 1916), and it is still the treatment of choice for the hemolymphatic stage of African sleeping sickness caused by Trypanosoma brucei rhodesiense.
Cal, Monica, Graf, Fabrice E., Kunz Renggli, Christina, Mäser, Pascal, Ndomba, Emiliana, Schmidt, Remo S., Wenzler, Tanja, Wiedemar, Natalie, Zwyer, Michaela   +8 more
core   +3 more sources

Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection. [PDF]

, 2019
Streptococcus gordonii and Streptococcus sanguinis are primary colonizers of the tooth surface. Although generally non-pathogenic in the oral environment, they are a frequent cause of infective endocarditis.
Barnard, Karen N, Bensing, Barbara A, Iverson, TM, Lebrilla, Carlito B, Li, Liang, Parrish, Colin R, Sullam, Paul M, Thomas, Wendy E, Wong, Maurice, Xiong, Yan, Yakovenko, Olga   +10 more
core   +3 more sources

Variant antigen diversity in Trypanosoma vivax is not driven by recombination

Nature Communications, 2020
Trypanosoma rely on variant surface glycoprotein (VSG) to escape host immunity, but mechanisms generating antigenic diversity of VSG are poorly understood. Here, Silva-Pereira et al. show that T.
Sara Silva Pereira, Kayo J. G. de Almeida Castilho Neto, Craig W. Duffy, Peter Richards, Harry Noyes, Moses Ogugo, Marcos Rogério André, Zakaria Bengaly, Steve Kemp, Marta M. G. Teixeira, Rosangela Z. Machado, Andrew P. Jackson   +11 more
doaj   +1 more source

Distinct, developmental stage-specific activation mechanisms of trypanosome VSG genes [PDF]

, 1990
The metacyclic form of African trypanosomes is the first to express genes for the Variant Surface Glycoprotein (VSG) and it uses an unusually predictable subset of the VSG gene repertoire.
Barry, J D, Graham, S V, Matthews, K R, Shiels, P G   +3 more
core   +1 more source