Results 21 to 30 of about 5,346,270 (244)

VSGs Expressed during Natural T. b. gambiense Infection Exhibit Extensive Sequence Divergence and a Subspecies-Specific Bias towards Type B N-Terminal Domains

mBio, 2022
Trypanosoma brucei gambiense is the primary causative agent of human African trypanosomiasis (HAT), a vector-borne disease endemic to West and Central Africa.
Jaime So, Sarah Sudlow, Abeer Sayeed, Tanner Grudda, Stijn Deborggraeve, Dieudonné Mumba Ngoyi, Didier Kashiama Desamber, Bill Wickstead, Veerle Lejon, Monica R. Mugnier   +9 more
doaj   +1 more source

Characterization of Trypanosoma brucei gambiense variant surface glycoprotein LiTat 1.5 [PDF]

, 2012
At present, all available diagnostic antibody detection tests for Trypanosoma brucei gambiense human African trypanosomiasis are based on predominant variant surface glycoproteins (VSGs), such as VSG LiTat 1.5. During investigations aiming at replacement
Rogé, S., Lejon, V., Guisez, Y., Van Nieuwenhove, L., Büscher, P., Rog\ue9, S.   +5 more
core   +1 more source

Molecular mechanisms underlying the control of antigenic variation in African trypanosomes [PDF]

, 2010
African trypanosomes escape the host adaptive immune response by switching their dense protective coat of Variant Surface Glycoprotein (VSG). Each cell expresses only one VSG gene at a time from a telomeric expression site (ES).
Horn, David, McCulloch, Richard, Horn, David; id_orcid, David Horn, Richard McCulloch   +4 more
core   +1 more source

Variant antigen diversity in Trypanosoma vivax is not driven by recombination

Nature Communications, 2020
Trypanosoma rely on variant surface glycoprotein (VSG) to escape host immunity, but mechanisms generating antigenic diversity of VSG are poorly understood. Here, Silva-Pereira et al. show that T.
Sara Silva Pereira, Kayo J. G. de Almeida Castilho Neto, Craig W. Duffy, Peter Richards, Harry Noyes, Moses Ogugo, Marcos Rogério André, Zakaria Bengaly, Steve Kemp, Marta M. G. Teixeira, Rosangela Z. Machado, Andrew P. Jackson   +11 more
doaj   +1 more source

Distinct, developmental stage-specific activation mechanisms of trypanosome VSG genes [PDF]

, 1990
The metacyclic form of African trypanosomes is the first to express genes for the Variant Surface Glycoprotein (VSG) and it uses an unusually predictable subset of the VSG gene repertoire.
Matthews, K R; id_orcid, Graham, S V, Shiels, P G, Barry, J D, P. G. Shiels, K. R. Matthews, S. V. Graham, J. D. Barry   +7 more
core   +1 more source

Analysis of adaptation mutants in the hemagglutinin of the influenza A(H1N1)pdm09 virus. [PDF]

PLoS ONE, 2013
Hemagglutinin is the major surface glycoprotein of influenza viruses. It participates in the initial steps of viral infection through receptor binding and membrane fusion events.
Alicia Jiménez-Alberto, Esmeralda Alvarado-Facundo, Rosa María Ribas-Aparicio, Juan A Castelán-Vega   +3 more
doaj   +1 more source

Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity [PDF]

, 2009
Antigenic variation is an immune evasion strategy that has evolved in viral, bacterial and protistan pathogens. In the African trypanosome this involves stochastic switches in the composition of a variant surface glycoprotein (VSG) coat, using a massive ...
Marcello, Lucio, McCulloch, Richard, R Mcculloch, Morrison, Liam J., L Marcello, L J Morrison   +5 more
core   +1 more source

N-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold

Nature Communications, 2016
How molecular crowding affects membrane protein diffusion and function is not known. Here the authors measure diffusion of variant surface glycoprotein on trypanosomes and discover a molecular crowding threshold that limits diffusion, and find that N ...
Andreas J. W. Hartel, Marius Glogger, Nicola G. Jones, Wasim Abuillan, Christopher Batram, Anne Hermann, Susanne F. Fenz, Motomu Tanaka, Markus Engstler   +8 more
doaj   +1 more source

Pedal to the Metal: Nuclear Splicing Bodies Turbo-Charge VSG mRNA Production in African Trypanosomes

Frontiers in Cell and Developmental Biology, 2022
The African trypanosome Trypanosoma brucei is a parasite of the mammalian bloodstream and tissues, where an antigenically variable Variant Surface Glycoprotein (VSG) coat protects it from immune attack.
James Budzak, Gloria Rudenko
doaj   +1 more source

Escaping the immune system by DNA repair and recombination in African trypanosomes [PDF]

Open Biology, 2019
African trypanosomes escape the mammalian immune response by antigenic variation—the periodic exchange of one surface coat protein, in Trypanosoma brucei the variant surface glycoprotein (VSG), for an immunologically distinct one.
Núria Sima, Emilia Jane McLaughlin, Sebastian Hutchinson, Lucy Glover   +3 more
doaj   +1 more source