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Parasitology, 2010 SUMMARYAfrican trypanosomes have emerged as promising unicellular model organisms for the next generation of systems biology. They offer unique advantages, due to their relative simplicity, the availability of all standard genomics techniques and a long history of quantitative research.
Bakker, B. +8 more
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VEX1 Influences mVSG Expression During the Transition to Mammalian Infectivity in Trypanosoma brucei
Frontiers in Cell and Developmental Biology, 2022 The Trypanosoma (T) brucei life cycle alternates between the tsetse fly vector and the mammalian host. In the insect, T. brucei undergoes several developmental stages until it reaches the salivary gland and differentiates into the metacyclic form, which ...
Eliane Tihon +6 more
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EBioMedicine, 2022 Summary: Background: To achieve elimination of Human African Trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense (gHAT), the development of highly sensitive diagnostics is needed.
Núria Sima +5 more
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mBio, 2022 The single-celled parasite Trypanosoma brucei is transmitted by hematophagous tsetse flies. Life cycle progression from mammalian bloodstream form to tsetse midgut form and, subsequently, infective salivary gland form depends on complex developmental ...
Caroline E. Dewar +7 more
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mBio, 2022 In the mammalian host, Trypanosoma brucei is coated in a single-variant surface glycoprotein (VSG) species. Stochastic switching of the expressed VSG allows the parasite to escape detection by the host immune system.
Emilia Jane McLaughlin +3 more
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The hows and whys of amastigote flagellum motility in Trypanosoma cruzi
mBio, 2023 The protist Trypanosoma cruzi exhibits several extracellular stages characterized by the presence of a long and motile flagellum and one intracellular life cycle stage termed amastigote, which possesses a tiny flagellum barely exiting the flagellar ...
Aline Araujo Alves, Philippe Bastin
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Barcoding in trypanosomes [PDF]
Parasitology, 2017 SUMMARYTrypanosomes (genus Trypanosoma) are parasites of humans, and wild and domestic mammals, in which they cause several economically and socially important diseases, including sleeping sickness in Africa and Chagas disease in the Americas. Despite the development of numerous molecular diagnostics and increasing awareness of the importance of these ...
RACHEL HUTCHINSON, JAMIE R. STEVENS
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Parasites & Vectors, 2020 Background Trypanosoma brucei exhibits a complex life-cycle alternating between tsetse flies and mammalian hosts. When parasites infect the fly, cells differentiate to adapt to life in various tissues, which is accompanied by drastic morphological and ...
Moara Lemos +5 more
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Parasites & Vectors, 2019 African trypanosomes cause human African trypanosomiasis and animal African trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa. Although most famous for their mechanisms of immune evasion by antigenic variation, there have been recent important studies that illuminate important aspects of the biology of these parasites both in ...
Cayla, Mathieu +4 more
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Parasitology, 2023 The bumblebee gut parasite, Crithidia bombi, is widespread and prevalent in the field. Its interaction with Bombus spp. is a well-established epidemiological model.
Hannah S. Wolmuth-Gordon +2 more
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