Results 1 to 10 of about 10,619 (187)

VEX1 Influences mVSG Expression During the Transition to Mammalian Infectivity in Trypanosoma brucei

Frontiers in Cell and Developmental Biology, 2022
The Trypanosoma (T) brucei life cycle alternates between the tsetse fly vector and the mammalian host. In the insect, T. brucei undergoes several developmental stages until it reaches the salivary gland and differentiates into the metacyclic form, which ...
Eliane Tihon, Karinna Rubio-Peña, Annick Dujeancourt-Henry, Aline Crouzols, Brice Rotureau, Brice Rotureau, Lucy Glover   +6 more
doaj   +1 more source

SHERLOCK4HAT: A CRISPR-based tool kit for diagnosis of Human African TrypanosomiasisResearch in context

EBioMedicine, 2022
Summary: Background: To achieve elimination of Human African Trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense (gHAT), the development of highly sensitive diagnostics is needed.
Núria Sima, Annick Dujeancourt-Henry, Blanca Liliana Perlaza, Marie-Noelle Ungeheuer, Brice Rotureau, Lucy Glover   +5 more
doaj   +1 more source

Oxidative Phosphorylation Is Required for Powering Motility and Development of the Sleeping Sickness Parasite Trypanosoma brucei in the Tsetse Fly Vector

mBio, 2022
The single-celled parasite Trypanosoma brucei is transmitted by hematophagous tsetse flies. Life cycle progression from mammalian bloodstream form to tsetse midgut form and, subsequently, infective salivary gland form depends on complex developmental ...
Caroline E. Dewar, Aitor Casas-Sanchez, Constentin Dieme, Aline Crouzols, Lee R. Haines, Álvaro Acosta-Serrano, Brice Rotureau, Achim Schnaufer   +7 more
doaj   +1 more source

Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei

mBio, 2022
In the mammalian host, Trypanosoma brucei is coated in a single-variant surface glycoprotein (VSG) species. Stochastic switching of the expressed VSG allows the parasite to escape detection by the host immune system.
Emilia Jane McLaughlin, Karinna Rubio-Pena, Annick Dujeancourt-Henry, Lucy Glover   +3 more
doaj   +1 more source

The hows and whys of amastigote flagellum motility in Trypanosoma cruzi

mBio, 2023
The protist Trypanosoma cruzi exhibits several extracellular stages characterized by the presence of a long and motile flagellum and one intracellular life cycle stage termed amastigote, which possesses a tiny flagellum barely exiting the flagellar ...
Aline Araujo Alves, Philippe Bastin
doaj   +1 more source

Timing and original features of flagellum assembly in trypanosomes during development in the tsetse fly

Parasites & Vectors, 2020
Background Trypanosoma brucei exhibits a complex life-cycle alternating between tsetse flies and mammalian hosts. When parasites infect the fly, cells differentiate to adapt to life in various tissues, which is accompanied by drastic morphological and ...
Moara Lemos, Adeline Mallet, Eloïse Bertiaux, Albane Imbert, Brice Rotureau, Philippe Bastin   +5 more
doaj   +1 more source

Methods matter: the influence of method on infection estimates of the bumblebee parasite Crithidia bombi

Parasitology, 2023
The bumblebee gut parasite, Crithidia bombi, is widespread and prevalent in the field. Its interaction with Bombus spp. is a well-established epidemiological model.
Hannah S. Wolmuth-Gordon, Anisah Sharmin, Mark J. F. Brown   +2 more
doaj   +1 more source

Distinct mRNA and protein interactomes highlight functional differentiation of major eIF4F-like complexes from Trypanosoma brucei

Frontiers in Molecular Biosciences, 2022
Gene expression in pathogenic protozoans of the family Trypanosomatidae has several novel features, including multiple eIF4F-like complexes involved in protein synthesis.
Maria J. R. Bezerra, Maria J. R. Bezerra, Danielle M. N. Moura, Eden R. Freire, Fabiola B. Holetz, Christian R. S. Reis, Tallyta T. S. Monteiro, Adriana R. S. Pinto, Ning Zhang, Antonio M. Rezende, Antonio Pereira-Neves, Regina C. B. Q. Figueiredo, Christine Clayton, Mark C. Field, Mark C. Field, Mark Carrington, Osvaldo P. de Melo Neto   +16 more
doaj   +1 more source

Turnover of Variant Surface Glycoprotein in Trypanosoma brucei Is Not Altered in Response to Specific Silencing

mSphere, 2022
African trypanosomes evade the immune system of the mammalian host by the antigenic variation of the predominant glycosylphosphatidylinositol (GPI)-anchored surface protein, variant surface glycoprotein (VSG).
Mohamed Sharif, Paige Garrison, Peter Bush, James D. Bangs   +3 more
doaj   +1 more source

Modulation of Virulence Factors during Trypanosoma cruzi Differentiation

Pathogens, 2022
Chagas disease is a neglected tropical disease caused by Trypanosoma cruzi. This protozoan developed several mechanisms to infect, propagate, and survive in different hosts.
Camila Oliveira, Fabíola Barbieri Holetz, Lysangela Ronalte Alves, Andréa Rodrigues Ávila   +3 more
doaj   +1 more source