Results 1 to 10 of about 25,592 (160)

Stumpy forms are the predominant transmissible forms of Trypanosoma brucei [PDF]

eLife
Schuster et al. demonstrated that bloodstream slender forms of African trypanosomes are readily transmissible to young tsetse flies where they can complete their complex life cycle (Schuster et al., 2021).
Jean Marc Tsagmo Ngoune, Parul Sharma, Aline Crouzols, Nathalie Petiot, Brice Rotureau   +4 more
doaj   +2 more sources

Trypanosome diversity in wildlife species from the Serengeti and Luangwa Valley ecosystems [PDF]

, 2012
<p>Background: The importance of wildlife as reservoirs of African trypanosomes pathogenic to man and livestock is well recognised. While new species of trypanosomes and their variants have been identified in tsetse populations, our knowledge of ...
Barbara Mable, Harriet Auty, Joseph Mathu Ndung'u, Joseph Mubanga, Kim Picozzi, Louise Hamill, Neil E. Anderson, Richard Hoare, Robert D. Fyumagwa, Sarah Cleaveland, Susan C. Welburn, Tiziana Lembo   +11 more
core   +19 more sources

VEX1 Influences mVSG Expression During the Transition to Mammalian Infectivity in Trypanosoma brucei

Frontiers in Cell and Developmental Biology, 2022
The Trypanosoma (T) brucei life cycle alternates between the tsetse fly vector and the mammalian host. In the insect, T. brucei undergoes several developmental stages until it reaches the salivary gland and differentiates into the metacyclic form, which ...
Eliane Tihon, Karinna Rubio-Peña, Annick Dujeancourt-Henry, Aline Crouzols, Brice Rotureau, Brice Rotureau, Lucy Glover   +6 more
doaj   +1 more source

SHERLOCK4HAT: A CRISPR-based tool kit for diagnosis of Human African TrypanosomiasisResearch in context

EBioMedicine, 2022
Summary: Background: To achieve elimination of Human African Trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense (gHAT), the development of highly sensitive diagnostics is needed.
Núria Sima, Annick Dujeancourt-Henry, Blanca Liliana Perlaza, Marie-Noelle Ungeheuer, Brice Rotureau, Lucy Glover   +5 more
doaj   +1 more source

Oxidative Phosphorylation Is Required for Powering Motility and Development of the Sleeping Sickness Parasite Trypanosoma brucei in the Tsetse Fly Vector

mBio, 2022
The single-celled parasite Trypanosoma brucei is transmitted by hematophagous tsetse flies. Life cycle progression from mammalian bloodstream form to tsetse midgut form and, subsequently, infective salivary gland form depends on complex developmental ...
Caroline E. Dewar, Aitor Casas-Sanchez, Constentin Dieme, Aline Crouzols, Lee R. Haines, Álvaro Acosta-Serrano, Brice Rotureau, Achim Schnaufer   +7 more
doaj   +1 more source

Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei

mBio, 2022
In the mammalian host, Trypanosoma brucei is coated in a single-variant surface glycoprotein (VSG) species. Stochastic switching of the expressed VSG allows the parasite to escape detection by the host immune system.
Emilia Jane McLaughlin, Karinna Rubio-Pena, Annick Dujeancourt-Henry, Lucy Glover   +3 more
doaj   +1 more source

The hows and whys of amastigote flagellum motility in Trypanosoma cruzi

mBio, 2023
The protist Trypanosoma cruzi exhibits several extracellular stages characterized by the presence of a long and motile flagellum and one intracellular life cycle stage termed amastigote, which possesses a tiny flagellum barely exiting the flagellar ...
Aline Araujo Alves, Philippe Bastin
doaj   +1 more source

The silicon trypanosome [PDF]

, 2010
African trypanosomes have emerged as promising unicellular model organisms for the next generation of systems biology. They offer unique advantages, due to their relative simplicity, the availability of all standard genomics techniques and a long history
BARBARA M. BAKKER, CHRISTINE CLAYTON, Duffieux, HANS V. WESTERHOFF, Hornberg, KEITH MATTHEWS, MARK GIROLAMI, MICHAEL P. BARRETT, PAUL A. M. MICHELS, R. LUISE KRAUTH-SIEGEL, RAINER BREITLING   +10 more
core   +8 more sources

Timing and original features of flagellum assembly in trypanosomes during development in the tsetse fly

Parasites & Vectors, 2020
Background Trypanosoma brucei exhibits a complex life-cycle alternating between tsetse flies and mammalian hosts. When parasites infect the fly, cells differentiate to adapt to life in various tissues, which is accompanied by drastic morphological and ...
Moara Lemos, Adeline Mallet, Eloïse Bertiaux, Albane Imbert, Brice Rotureau, Philippe Bastin   +5 more
doaj   +1 more source

Infections with extracellular trypanosomes require control by efficient innate immune mechanisms and can result in the destruction of the mammalian humoral immune system [PDF]

, 2020
Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game animals around the world. Through co-evolution with the mammalian immune system, trypanosomes have developed defense mechanisms that allow them to thrive in blood,
Magez, Stefan, Obishakin, Emmanuel Tumininu, Pinto Torres, Joar Esteban, Radwanska, Magdalena   +3 more
core   +1 more source