Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation. [PDF]
PLoS ONE, 2009 BackgroundThe African trypanosome Trypanosoma brucei is covered with a dense layer of Variant Surface Glycoprotein (VSG), which protects it from lysis by host complement via the alternative pathway in the mammalian bloodstream.
Terry K Smith +9 more
doaj +3 more sources
Expression of Procyclin mRNAs during Cyclical Transmission of Trypanosoma brucei. [PDF]
PLoS Pathogens, 2005 Trypanosoma brucei, the parasite causing human sleeping sickness, relies on the tsetse fly for its transmission. In the insect, EP and GPEET procyclins are the major surface glycoproteins of procyclic (midgut) forms of the parasite, with GPEET ...
Simon Urwyler +6 more
doaj +5 more sources
Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4'-epimerase conditional null mutant [PDF]
, 2006 Galactose metabolism is essential for the survival of Trypanosoma brucei, the etiological agent of African sleeping sickness. T. brucei hexose transporters are unable to transport galactose, which is instead obtained through the epimerization of UDP ...
Turnock, Daniel C. +2 more
core +5 more sources
An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes
Nature Communications, 2022 A Variant Surface Glycoprotein (VSG) coat protects bloodstream form T. brucei. Applying super-resolution microscopy Budzak et al. characterize a set of nuclear bodies, which associate with the active expression site in bloodstream form T.
James Budzak +4 more
doaj +1 more source
SUMOylated SNF2PH promotes variant surface glycoprotein expression in bloodstream trypanosomes. [PDF]
EMBO Rep, 2019 SUMOylation is a post-translational modification that positively regulates monoallelic expression of the trypanosome variant surface glycoprotein (VSG).
Saura A +10 more
europepmc +2 more sources
Microbiology Spectrum, 2022 Ebola virus, a member of the Filoviridae family, utilizes the attachment factors on host cells to support its entry and cause severe tissue damage. TIM-1 has been identified as a predominant attachment factor via interaction with phosphatidylserine (PS ...
Min Zhang +14 more
doaj +1 more source
A Short Series of Case Reports of COVID-19 in Immunocompromised Patients
Viruses, 2022 Immunocompromised individuals are at risk of prolonged SARS-CoV-2 infection due to weaker immunity, co-morbidities, and lowered vaccine effectiveness, which may evolve highly mutated variants of SARS-CoV-2.
Mitali Mishra +9 more
doaj +1 more source
Cell Reports, 2020 Summary: Trypanosoma brucei evades mammalian immunity by using recombination to switch its surface-expressed variant surface glycoprotein (VSG), while ensuring that only one of many subtelomeric multigene VSG expression sites are transcribed at a time ...
Jennifer Ann Black +7 more
doaj +1 more source
Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease. [PDF]
PLoS Genetics, 2018 Paired Immunoglobulin-like Type 2 Receptor Alpha (PILRA) is a cell surface inhibitory receptor that recognizes specific O-glycosylated proteins and is expressed on various innate immune cell types including microglia.
Nisha Rathore +14 more
doaj +1 more source
The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei [PDF]
, 2010 Sphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T.
Smith, Terry K. +4 more
core +1 more source