Results 31 to 40 of about 62,350 (249)
Pedal to the Metal: Nuclear Splicing Bodies Turbo-Charge VSG mRNA Production in African Trypanosomes
Frontiers in Cell and Developmental Biology, 2022 The African trypanosome Trypanosoma brucei is a parasite of the mammalian bloodstream and tissues, where an antigenically variable Variant Surface Glycoprotein (VSG) coat protects it from immune attack.
James Budzak, Gloria Rudenko
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Mutational sensitivity of D614G in spike protein of SARS-CoV-2 in Jordan
Biochemistry and Biophysics Reports, 2021 Background: Spike protein is the surface glycoprotein of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) necessary for the entry of the virus via the transmembrane receptors of the human respiratory cells causing COVID-19 disease.
Walid Al-Zyoud, Hazem Haddad
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BMC Genomics, 2007 Background In a mammalian host, the cell surface of African trypanosomes is protected by a monolayer of a single variant surface glycoprotein (VSG). The VSG is central to antigenic variation; one VSG gene is expressed at any one time and there is a low ...
Sharma Reuben +6 more
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Expression of Procyclin mRNAs during Cyclical Transmission of Trypanosoma brucei. [PDF]
PLoS Pathogens, 2005 Trypanosoma brucei, the parasite causing human sleeping sickness, relies on the tsetse fly for its transmission. In the insect, EP and GPEET procyclins are the major surface glycoproteins of procyclic (midgut) forms of the parasite, with GPEET ...
Simon Urwyler +6 more
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Transmembrane and truncated (SEC) isoforms of MUC1 in the human endometrium and Fallopian tube
Reproductive Biology and Endocrinology, 2003 The cell surface mucin MUC1 is expressed by endometrial epithelial cells with increased abundance in the secretory phase of the menstrual cycle, when it is found both at the apical cell surface and in secretions.
Wreschner Daniel H +6 more
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An extensive endoplasmic reticulum-localised glycoprotein family in trypanosomatids
Microbial Cell, 2014 African trypanosomes are evolutionarily highly divergent parasitic protozoa, and as a consequence the vast majority of trypanosome membrane proteins remain uncharacterised in terms of location, trafficking or function.
Harriet Allison +3 more
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PLoS Pathogens, 2012 The transferrin receptor of bloodstream form Trypanosoma brucei is a heterodimer encoded by expression site associated genes 6 and 7. This low-abundance glycoprotein with a single glycosylphosphatidylinositol membrane anchor and eight potential N ...
Angela Mehlert +2 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
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Repression and reactivation of the variant surface glycoprotein gene in Trypanosoma brucei [PDF]
FEBS Letters, 1987 Rapid repression of variant surface glycoprotein (VSG) synthesis is an early event during the in vitro transformation of Trypanosoma brucei from coated bloodstream forms to uncoated procyclic cells. Repression occurs at the transcriptional level and is triggered by the combined action of two signals: a reduction in temperature from 37 to 27°C and the ...
Ehlers, Bernhard +2 more
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
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