Results 31 to 40 of about 5,346,270 (244)

Immunodominant surface epitopes power immune evasion in the African trypanosome

Cell Reports, 2023
Summary: The African trypanosome survives the immune response of its mammalian host by antigenic variation of its major surface antigen (the variant surface glycoprotein or VSG). Here we describe the antibody repertoires elicited by different VSGs.
Anastasia Gkeka, Francisco Aresta-Branco, Gianna Triller, Evi P. Vlachou, Monique van Straaten, Mirjana Lilic, Paul Dominic B. Olinares, Kathryn Perez, Brian T. Chait, Renata Blatnik, Thomas Ruppert, Joseph P. Verdi, C. Erec Stebbins, F. Nina Papavasiliou   +13 more
doaj   +1 more source

Mutational sensitivity of D614G in spike protein of SARS-CoV-2 in Jordan

Biochemistry and Biophysics Reports, 2021
Background: Spike protein is the surface glycoprotein of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) necessary for the entry of the virus via the transmembrane receptors of the human respiratory cells causing COVID-19 disease.
Walid Al-Zyoud, Hazem Haddad
doaj   +1 more source

Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific

BMC Genomics, 2007
Background In a mammalian host, the cell surface of African trypanosomes is protected by a monolayer of a single variant surface glycoprotein (VSG). The VSG is central to antigenic variation; one VSG gene is expressed at any one time and there is a low ...
Sharma Reuben, Mott Helen, Jones Nicola G, Picozzi Kim, Hutchinson O Clyde, Welburn Susan C, Carrington Mark   +6 more
doaj   +1 more source

Life and times:synthesis, trafficking, and evolution of VSG [PDF]

, 2014
Evasion of the acquired immune response in African trypanosomes is principally mediated by antigenic variation, the sequential expression of distinct variant surface glycoproteins (VSGs) at extremely high density on the cell surface.
Boehm, Cordula, Cordula Boehm, Senthil Kumar Natesan, Paul T. Manna, Ka Fai Leung, Natesan, Senthil Kumar, Field, Mark C., Leung, Ka Fai, Mark C. Field, Manna, Paul T.   +9 more
core   +1 more source

Antigenic variation in Trypanosoma brucei: joining the DOTs [PDF]

, 2008
African trypanosomes, such as <i>Trypanosoma brucei</i>, are protistan parasites that cause sleeping sickness. Though first described more than a century ago, trypanosomes remain a blight on the health of the human population and on the ...
Swiderski, Michal R., J David Barry, McCulloch, Richard, Michal R Swiderski, Chris Stockdale, McCulloch Richard, Barry, J. David, Stockdale Chris, Barry J. David, Stockdale, Chris, Richard McCulloch, Swiderski Michal R   +11 more
core   +1 more source

Trypanosoma Variant Surface Glycoprotein: A Review

مجلة الانبار للعلوم البيطرية
The glycoprotein surface of the Trypanosoma parasite plays a crucial role in the organism’s biology, as a protective barrier that facility invasion to the host.
Kalef, Dalia Ahmed, Shather, Maulood M
doaj   +1 more source

Expression and modulation of CD44 variant isoforms in humans [PDF]

, 1994
CD44 is a ubiquitous surface molecule that exists as a number of isoforms, generated by alternative splicing of 10 "variant" exons. Little is known about the expression and function of the variant isoforms, except that certain isoforms may play a role in
Mackay, C. R., H Stark, Günthert, U., Stauder, R., HJ Terpe, Stark, H., R Stauder, U Günthert, Terpe, H. J., Marston, W. L., WL Marston, CR Mackay   +11 more
core   +1 more source

Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species [PDF]

, 2012
Antigenic variation enables pathogens to avoid the host immune response by continual switching of surface proteins. The protozoan blood parasite Trypanosoma brucei causes human African trypanosomiasis ("sleeping sickness") across sub-Saharan Africa and ...
Browne, H., Jackson, Andrew P., Marcello, Lucio, Jackson, A.P., Jackson, A. P., Quail, M. A., Marcello, L., Quail, M.A., Berriman, Matthew, Jackson, Andrew P, Berry, Andrew, Field, M. C., Aslett, Martin, Sanders, Mandy J., McQuillan, J., Barry, J. David, Field, Mark C., Allinson, Harriet C., Browne, Hilary, Hauser, H., Aslett, M., Barry, J.D., Burton, Peter, Allison, Harriet C., Ginger, Michael L., Gilderthorp, Ruth, Berry, A., van Tonder, Andries, Allison, H.C., McQuillan, Jacqueline, Burton, P., Ginger, M.L., Corton, Nicola, Gilderthorp, R., Hertz-Fowler, Christiane, Field, M.C., Field, MarkC., Corton, N., Quail, Michael A., Gamble, John, Brown, R., Otto, Thomas D., Otto, T. D., Barry, J. D., Gamble, J., Hauser, Heidi, Hertz-Fowler, C., Brown, Robert, van Tonder, A., Berriman, M., Ginger, Michael, Vavrova-Anderson, Jana, Vavrova-Anderson, J., Sanders, M.J., Allison, H. C., Hertz-Fowler, Christine, Otto, T.D., Sanders, M. J.   +57 more
core   +1 more source

Bloodstream form trypanosoma brucei depend upon multiple metacaspases associated with RAB11-positive endosomes [PDF]

, 2006
Trypanosoma brucei possesses five metacaspase genes. Of these, MCA2 and MCA3 are expressed only in the mammalian bloodstream form of the parasite, whereas MCA5 is expressed also in the insect procyclic form.
Appleton, Paul, Ambit, Audrey, Helms, Matthew J., Tetley, Laurence, Mottram, Jeremy C., Coombs, Graham H.   +5 more
core   +3 more sources

Transmembrane and truncated (SEC) isoforms of MUC1 in the human endometrium and Fallopian tube

Reproductive Biology and Endocrinology, 2003
The cell surface mucin MUC1 is expressed by endometrial epithelial cells with increased abundance in the secretory phase of the menstrual cycle, when it is found both at the apical cell surface and in secretions.
Wreschner Daniel H, Smorodinsky Nechama I, Simón Carlos, Meseguer Marcos, Hey Neil A, Ortíz María, Aplin John D   +6 more
doaj   +1 more source