Results 51 to 60 of about 113,459 (293)

Modeling of the N-glycosylated transferrin receptor suggests how transferrin binding can occur within the surface coat of Trypanosoma brucei.

PLoS Pathogens, 2012
The transferrin receptor of bloodstream form Trypanosoma brucei is a heterodimer encoded by expression site associated genes 6 and 7. This low-abundance glycoprotein with a single glycosylphosphatidylinositol membrane anchor and eight potential N ...
Angela Mehlert, Mark R Wormald, Michael A J Ferguson   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity [PDF]

, 2009
Antigenic variation is an immune evasion strategy that has evolved in viral, bacterial and protistan pathogens. In the African trypanosome this involves stochastic switches in the composition of a variant surface glycoprotein (VSG) coat, using a massive ...
Marcello, Lucio, McCulloch, Richard, Morrison, Liam J.   +2 more
core   +1 more source

Variant Surface Glycoprotein Diversity in African Trypanosomes [PDF]

, 2018
African trypanosomes are vector-borne haemoparasites that cause animal and human African trypanosomiasis. Survival in the mammal host is mediated by antigenic variation, an immune evasion mechanism based on the sequential replacement of the Variant Surface Glycoprotein (VSG) coat that covers the parasite surface.
openaire   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation.

PLoS ONE, 2009
BackgroundThe African trypanosome Trypanosoma brucei is covered with a dense layer of Variant Surface Glycoprotein (VSG), which protects it from lysis by host complement via the alternative pathway in the mammalian bloodstream.
Terry K Smith, Nadina Vasileva, Eva Gluenz, Stephen Terry, Neil Portman, Susanne Kramer, Mark Carrington, Shulamit Michaeli, Keith Gull, Gloria Rudenko   +9 more
doaj   +1 more source

A trypanosome-derived immunotherapeutics platform elicits potent high-affinity antibodies, negating the effects of the synthetic opioid fentanyl

Cell Reports, 2023
Summary: Poorly immunogenic small molecules pose challenges for the production of clinically efficacious vaccines and antibodies. To address this, we generate an immunization platform derived from the immunogenic surface coat of the African trypanosome ...
Gianna Triller, Evi P. Vlachou, Hamidreza Hashemi, Monique van Straaten, Johan P. Zeelen, Yosip Kelemen, Carly Baehr, Cheryl L. Marker, Sandra Ruf, Anna Svirina, Monica Chandra, Katharina Urban, Anastasia Gkeka, Sebastian Kruse, Andreas Baumann, Aubry K. Miller, Marc Bartel, Marco Pravetoni, C. Erec Stebbins, F. Nina Papavasiliou, Joseph P. Verdi   +20 more
doaj   +1 more source

Human African trypanosomiasis [PDF]

, 2009
Human African trypanosomiasis (sleeping sickness) occurs in sub-Saharan Africa. It is caused by the protozoan parasite Trypanosoma brucei, transmitted by tsetse flies.
Abel, Agranoff, Ancelle, Ayed, Balasegaram, Balasegaram, Barrett, Barrett, Barrett, Bayer, Bedat-Millet, Bisoffi, Bisser, Bisser, Blum, Blum, Blum, Blum, Blum, Blum, Bronner, Brun, Buguet, Burri, Burri, Chappuis, Chappuis, Chappuis, Chappuis, Chappuis, Chappuis, Checchi, Checchi, Christian Burri, Courtioux, De Raadt, Deborggraeve, Deborggraeve, Dorlo, Doua, Duggan, Dukes, Ekwanzala, Enyaru, Ezzedine, Fevre, Fevre, Francois Chappuis, Greenwood, Gustafsson, Hutchinson, Iborra, Inojosa, Iten, Jamonneau, Jamonneau, Jamonneau, Jamonneau, Jamonneau, Jansson, Jelinek, Johannes Blum, Jordan, Joshi, Kabasa, Kennedy, Kennedy, Koten, Lejon, Lejon, Lejon, Lejon, Lejon, Lejon, Lejon, Lejon, Louis, Lumsden, Lundkvist, Lutumba, Lutumba, Lutumba, Lutumba, MacLean, Macleod, Magnus, Marcello, Marcello, Masocha, Maudlin, Mendonca, Moore, Moore, Moore, Na-Bangchang, Njiokou, Njiru, Noireau, Noireau, Odiit, Odiit, Oscherwitz, Papadopoulos, Paquet, Penchenier, Pepin, Picozzi, Priotto, Priotto, Priotto, Reincke, Reto Brun, Ripamonti, Robays, Robays, Ruiz, Schmid, Shiflett, Simarro, Simarro, Simarro, Simo, Smith, Spencer, Stanghellini, Stevens, Steverding, Steverding, Stijlemans, Stuart, Taylor, Torr, Truc, Truc, Truc, Truc, Van Meirvenne, Van Nieuwenhove, Vanhamme, Vanhollebeke, Vreysen, Welburn, Welburn, Woo   +143 more
core   +2 more sources

Maintaining the protective variant surface glycoprotein coat of African trypanosomes [PDF]

Biochemical Society Transactions, 2005
The African trypanosome Trypanosoma brucei has a precarious existence as an extracellular parasite of the mammalian bloodstream, where it is faced with continuous immune attack. Key to survival is a dense VSG (variant surface glycoprotein) coat, which is repeatedly switched during the course of a chronic infection.
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source