Results 51 to 60 of about 62,350 (249)
Myristate exchange on the Trypanosoma brucei variant surface glycoprotein. [PDF]
Proceedings of the National Academy of Sciences, 1996 The glycosyl-phosphatidylinositol (GPI) anchor of the Trypanosoma brucei variant surface glycoprotein (VSG) is unique in having exclusively myristate as its fatty acid component. We previously demonstrated that the myristate specificity is the result of two independent pathways.
L U, Buxbaum +3 more
openaire +2 more sources
Advanced Functional Materials, EarlyView.A bio‐inspired biopolymeric implantable drug delivery platform enables localized and sustained release of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38) in solid tumor treatment. The three‐dimensional (3D) structured crosslinked‐chitosan implants are fabricated via 3D‐printed molds and provide drug release over 3 months, significantly inhibiting tumor growth ...
Mercedes Lozano‐Garcia +12 more
wiley +1 more source
Wellcome Open ResearchTrypanosoma brucei is an extracellular eukaryotic parasite that causes sleeping sickness in humans and Nagana, Surra and Dourine in livestock, game animals and horses.
Stephen Larcombe +4 more
doaj +1 more source
Intracellular transport of a variant surface glycoprotein in Trypanosoma brucei. [PDF]
The Journal of cell biology, 1988 Trypanosome variant surface glycoproteins (VSGs) have a novel glycan-phosphatidylinositol membrane anchor, which is cleavable by a phosphatidylinositol-specific phospholipase C. A similar structure serves to anchor some membrane proteins in mammalian cells.
Duszenko, Michael +4 more
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.A nanofiber‐supported decellularized extracellular matrix (NaDE) membrane recreates key biochemical and mechanical features of native intestinal tissue. This platform enables the formation of a more physiologically relevant intestinal epithelium, enhancing stem cell maintenance and promoting diverse cell differentiation.
Jaeseung Youn +7 more
wiley +1 more source
New Trypanosoma evansi Type B Isolates from Ethiopian Dromedary Camels.
PLoS Neglected Tropical Diseases, 2016 BackgroundTrypanosoma (T.) evansi is a dyskinetoplastic variant of T. brucei that has gained the ability to be transmitted by all sorts of biting flies. T.
Hadush Birhanu +4 more
doaj +1 more source
Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein.
PLoS Pathogens, 2020 The HIV-1 envelope glycoprotein (Env) mediates viral entry via conformational changes associated with binding the cell surface receptor (CD4) and coreceptor (CCR5/CXCR4), resulting in subsequent fusion of the viral and cellular membranes. While the gp120
Vinita R Joshi +9 more
doaj +1 more source
Variant Surface Glycoprotein Diversity in African Trypanosomes [PDF]
, 2018 African trypanosomes are vector-borne haemoparasites that cause animal and human African trypanosomiasis. Survival in the mammal host is mediated by antigenic variation, an immune evasion mechanism based on the sequential replacement of the Variant Surface Glycoprotein (VSG) coat that covers the parasite surface.
openaire +1 more source
The glycoforms of a Trypanosoma brucei variant surface glycoprotein and molecular modeling of a glycosylated surface coat [PDF]
Glycobiology, 2002 The plasma membrane of the African sleeping sickness parasite Trypanosoma brucei is covered with a dense, protective surface coat. This surface coat is a monolayer of five million variant surface glycoprotein (VSG) dimers that form a macromolecular diffusion barrier.
Mehlert, Angela +2 more
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.Chamber‐specific decellularized extracellular matrices (ECMs) were developed, preserving native proteomic profiles of ventricular and atrial myocardium. These innate biochemical cues differentially modulate cardiomyocyte subtypes to drive engineered heart tissue development and function, highlighting the importance of incorporating regional ECM cues in
Dong Gyu Hwang +7 more
wiley +1 more source