Results 61 to 70 of about 113,459 (293)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

A structural classification of the variant surface glycoproteins of the African trypanosome.

PLoS Neglected Tropical Diseases, 2023
Long-term immune evasion by the African trypanosome is achieved through repetitive cycles of surface protein replacement with antigenically distinct versions of the dense Variant Surface Glycoprotein (VSG) coat.
Sara Đaković, Johan P Zeelen, Anastasia Gkeka, Monica Chandra, Monique van Straaten, Konstantina Foti, Janet Zhong, Evi P Vlachou, Francisco Aresta-Branco, Joseph P Verdi, F Nina Papavasiliou, C Erec Stebbins   +11 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Parasite motility is critical for virulence of African trypanosomes. [PDF]

, 2018
African trypanosomes, Trypanosoma brucei spp., are lethal pathogens that cause substantial human suffering and limit economic development in some of the world's most impoverished regions.
Geng, Quanjie, Hill, Kent L, Kisalu, Neville, Ozcan, Aydogan, Ray, Sunayan S, Shimogawa, Michelle M, Zhang, Yibo   +6 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei

eLife, 2014
We have discovered a new mechanism of monoallelic gene expression that links antigenic variation, cell cycle, and development in the model parasite Trypanosoma brucei. African trypanosomes possess hundreds of variant surface glycoprotein (VSG) genes, but
Christopher Batram, Nicola G Jones, Christian J Janzen, Sebastian M Markert, Markus Engstler   +4 more
doaj   +1 more source

The Fusion Activity of HIV-1 gp41 Depends on Interhelical Interactions [PDF]

, 2005
Infection by human immunodeficiency virus type I requires the fusogenic activity of gp41, the transmembrane subunit of the viral envelope protein. Crystallographic studies have revealed that fusion-active gp41 is a "trimer-of-hairpins" in which three ...
Chan, David C., Suntoke, Tara R.
core   +1 more source

Identification of Peptide Mimotopes of Trypanosoma brucei gambiense Variant Surface Glycoproteins

PLoS Neglected Tropical Diseases, 2011
The current antibody detection tests for the diagnosis of gambiense human African trypanosomiasis (HAT) are based on native variant surface glycoproteins (VSGs) of Trypanosoma brucei (T.b.) gambiense. These native VSGs are difficult to produce, and contain non-specific epitopes that may cause cross-reactions. We aimed to identify mimotopic peptides for
Van Nieuwenhove, Liesbeth, Roge, Stijn, Balharbi, Fatima, Dieltjens, Tessa, Laurent, Thierry, Guisez, Yves, Buscher, Philippe, Lejon, Veerle   +7 more
openaire   +5 more sources

Control of variant surface glycoprotein gene-expression sites in Trypanosoma brucei [PDF]

The EMBO Journal, 1999
Trypanosoma brucei has 20 similar telomeric-expression sites for variant surface glycoprotein genes. Expression sites appear to be controlled at the level of transcription initiation, resulting in only one site being active at any time. Switching between expression sites occurs at a low rate.
I, Chaves, G, Rudenko, A, Dirks-Mulder, M, Cross, P, Borst   +4 more
openaire   +2 more sources