Results 61 to 70 of about 5,346,270 (244)

of High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes

, 2016
of High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African ...
Sebastian Hutchinson (3500945), Lucy Glover (24966), David Horn (24969)   +2 more
core   +1 more source

Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein.

PLoS Pathogens, 2020
The HIV-1 envelope glycoprotein (Env) mediates viral entry via conformational changes associated with binding the cell surface receptor (CD4) and coreceptor (CCR5/CXCR4), resulting in subsequent fusion of the viral and cellular membranes. While the gp120
Vinita R Joshi, Ruchi M Newman, Melissa L Pack, Karen A Power, James B Munro, Ken Okawa, Navid Madani, Joseph G Sodroski, Aaron G Schmidt, Todd M Allen   +9 more
doaj   +1 more source

Melanin's Role in Balancing Mechanical Strength and Reproductive Output in Environmentally Stressed Fungal Spores

Advanced Functional Materials, EarlyView.
Melanin content directly controls fungal spore mechanical properties, with pigmented spores achieving rupture forces two orders of magnitude higher than hyaline spores. Environmental stress drives this quantity‐quality tradeoff; stressed species invest energy in melanin‐reinforced, mechanically superior thick‐walled, super‐hydrophobic spores, while ...
Atul Agrawal, Steven E. Naleway
wiley   +1 more source

New Trypanosoma evansi Type B Isolates from Ethiopian Dromedary Camels.

PLoS Neglected Tropical Diseases, 2016
BackgroundTrypanosoma (T.) evansi is a dyskinetoplastic variant of T. brucei that has gained the ability to be transmitted by all sorts of biting flies. T.
Hadush Birhanu, Tadesse Gebrehiwot, Bruno Maria Goddeeris, Philippe Büscher, Nick Van Reet   +4 more
doaj   +1 more source

The Trypanosoma Brucei KIFC1 Kinesin Ensures the Fast Antibody Clearance Required for Parasite Infectivity

iScience, 2020
Summary: Human innate immunity to Trypanosoma brucei involves the trypanosome C-terminal kinesin TbKIFC1, which transports internalized trypanolytic factor apolipoprotein L1 (APOL1) within the parasite. We show that TbKIFC1 preferentially associates with
Laurence Lecordier, Sophie Uzureau, Gilles Vanwalleghem, Magali Deleu, Jean-Marc Crowet, Paul Barry, Barry Moran, Paul Voorheis, Andra-Cristina Dumitru, Yoshiki Yamaryo-Botté, Marc Dieu, Patricia Tebabi, Benoit Vanhollebeke, Laurence Lins, Cyrille Y. Botté, David Alsteens, Yves Dufrêne, David Pérez-Morga, Derek P. Nolan, Etienne Pays   +19 more
doaj   +1 more source

Hemocompatible Glycogen‐Tissue Plasminogen Activator Complexes for Enhanced Blood Clot Dissolution

Advanced Healthcare Materials, EarlyView.
Glycogen–heparin‐cRGD nanoparticles enable targeted delivery of tissue plasminogen activator (tPA) to thrombi through activated platelet recognition. The hemocompatible hybrids minimize interactions with blood and immune cells while retaining enzymatic biodegradability.
Nadiia Davydiuk, Vaidehi Londhe, Susanne Boye, Martin Müller, Carsten Werner, Manfred F. Maitz, Quinn A. Besford   +6 more
wiley   +1 more source

NUP-1 is a large coiled-coil nucleoskeletal protein in Trypanosomes with lamin-like functions [PDF]

, 2012
A unifying feature of eukaryotic nuclear organization is genome segregation into transcriptionally active euchromatin and transcriptionally repressed heterochromatin.
Wan, Yakun, Kelly N DuBois, J. David Barry, Rout, Michael P., Alsford, S., Holden, Jennifer M., DuBois, K.N., Rout Michael P., Rout, Michael P, Jean-Mathieu Bart (176093), Field, Mark C, DuBois, Kelly N., Alsford Sam, Aitchison, J.D., Buisson, J., Mathieu Bart, Barry, J. David, Navarro Miguel, Horn David, Field, Mark C., Field Mark C., Misteli, T., Ratushny, Alexander V., Swiderski, Michal, Horn, David, Rout, M.P., Mark C. Field (129657), David Horn (24969), Jennifer M. Holden, Bastin Philippe, DuBois, Kelly N, Alexander V. Ratushny (102304), Barry, J.D., Barry, J David, Holden Jennifer M., Miguel Navarro, Michal Swiderski (176090), John D. Aitchison (102330), Bart, J., Johanna Buisson, J David Barry, John D. Aitchison, Holden, Jennifer M, Bastin, Philippe, DuBois Kelly N., Navarro, M., Barry J. David, Philippe Bastin (25974), Michael P. Rout (25373), Aitchison John D., Jennifer M Holden, Ratushny, A.V., Kelly N. Dubois, Buisson Johanna, Field, M.C., Alsford, Sam, Philippe Bastin, Swiderski, M., Wan, Y., Ratushny, Alexander V, Bastin, P., Kelly N. DuBois (176072), Horn, D., Michael P Rout, Aitchison, John D, Jean-Mathieu Bart, Buisson, Johanna, Bart, Jean-Mathieu, Sam Alsford (24967), Yakun Wan, David Horn, Mark C. Field, J. David Barry (60385), Navarro, Miguel, Aitchison, John D., Jennifer M. Holden (176080), Miguel Navarro (176103), Sam Alsford, Bart Jean-Mathieu, Ratushny Alexander V., Michael P. Rout, Yakun Wan (176097), Wan Yakun, Horn, David; id_orcid, Holden, J.M., Swiderski Michal, John D Aitchison, Mark C Field, Johanna Buisson (176084), Michal Swiderski, Er V. Ratushny, Alexander V Ratushny   +91 more
core   +2 more sources

Charge‐Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti‐Cancer Treatment

Advanced Materials, EarlyView.
Charge‐reversed lipid nanoparticles (revLNPs) enable efficient encapsulation and delivery of cationic Pt2L4 nanocages. Encapsulation preserves potent anticancer activity while improving circulation, reducing vascular leakage, and promoting favorable biodistribution in vivo.
Renzo A. Knol, Bochuan Hu, Eduard O. Bobylev, Martina Farber, Petrus C. M. Laan, Thomas J. F. Kock, Bauke Fontein, Johanna Erbani, Oscar Escalona‐Rayo, Seline S. Roose, Tom Keijer, Gabriel Forn‐Cuní, B. Ewa Snaar‐Jagalska, Leila Akkari, Joost N. H. Reek, Alexander Kros, Dennis Aschmann   +16 more
wiley   +1 more source

Life‐Like Ferrous Oxide Microspheres from Kombucha

Advanced Materials Interfaces, EarlyView.
Kombucha bacterial cellulose, sodium alginate, and ferrous nitrate self‐assemble into membrane‐enclosed iron oxide microspheres. These microspheres bud daughter vesicles, sustain 24‐h electrochemical oscillations, and filter theta‐band signals.
Panagiotis Mougkogiannis, Anna Nikolaidou, Andrew Adamatzky   +2 more
wiley   +1 more source

Antibody‐Precomplexed Hemagglutinin Constructs Multivalently Bind Sialylated Glycan Receptors with Variable Valencies

Advanced Materials Interfaces, EarlyView.
Hemagglutinin precomplexation with antibodies (Abs) results in broad valency distributions, though it increases the total avidity from mM to nM to high nM. The valency distribution and the orientation of multivalent HA‐Ab complexes determine the extent of binding to different types of assays, whether the receptors are displayed in 2D or 3D.
Daniel Y. E. L. Tambuwun, María Ríos Carrasco, Elif Uslu, Geert‐Jan P. H. Boons, Nadia J. Mokiem, Albert J. R. Heck, Victor C. Yin, Robert P. de Vries, Jurriaan Huskens   +8 more
wiley   +1 more source