Results 61 to 70 of about 62,350 (249)

The Trypanosoma Brucei KIFC1 Kinesin Ensures the Fast Antibody Clearance Required for Parasite Infectivity

iScience, 2020
Summary: Human innate immunity to Trypanosoma brucei involves the trypanosome C-terminal kinesin TbKIFC1, which transports internalized trypanolytic factor apolipoprotein L1 (APOL1) within the parasite. We show that TbKIFC1 preferentially associates with
Laurence Lecordier, Sophie Uzureau, Gilles Vanwalleghem, Magali Deleu, Jean-Marc Crowet, Paul Barry, Barry Moran, Paul Voorheis, Andra-Cristina Dumitru, Yoshiki Yamaryo-Botté, Marc Dieu, Patricia Tebabi, Benoit Vanhollebeke, Laurence Lins, Cyrille Y. Botté, David Alsteens, Yves Dufrêne, David Pérez-Morga, Derek P. Nolan, Etienne Pays   +19 more
doaj   +1 more source

The interaction of Trypanosoma brucei with antibodies to variant surface glycoproteins

Journal of Cell Science, 1990
ABSTRACT Binding to Trypanosoma brucei of polyvalent IgMs and IgGs, monoclonal IgGs and Fabi fragments of monoclonal IgGs specific for exposed epitopes of T. brucei variant surface glycoproteins (VSGs) was monitored by both immunofluorescence and immu-nocytochemistry. All antibodies and antibody fragments, were uniformly distributed over
Webster, P., Russo, D.C.W., Black, Samuel J.   +2 more
openaire   +2 more sources

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Engineering Nanoplatforms for Alzheimer's Disease Detection via Biomolecular Corona Proteomic and Lipidomic Profiling

Advanced Healthcare Materials, EarlyView.
Engineered nanoparticles capture disease‐specific biomolecular coronas that uncover hidden molecular features of Alzheimer's disease. Combined proteomic and lipidomic analyses reveal a characteristic shift in ribosomal machinery and energy metabolism, generating a multiomic fingerprint that supports accurate disease detection and opens new ...
Antonietta Greco, Roberto Baretta, Andrea Di Fonzo, Andrea Armirotti, Stefano Cinti, Mara Mirasoli, Marco Frasconi, Claudia Corbo   +7 more
wiley   +1 more source

Maintaining the protective variant surface glycoprotein coat of African trypanosomes [PDF]

Biochemical Society Transactions, 2005
The African trypanosome Trypanosoma brucei has a precarious existence as an extracellular parasite of the mammalian bloodstream, where it is faced with continuous immune attack. Key to survival is a dense VSG (variant surface glycoprotein) coat, which is repeatedly switched during the course of a chronic infection.
openaire   +2 more sources

Multifunctional Catechol‐Functionalized Cellulose Hydrogels for the Minimally Invasive Treatment of Acute Optic Nerve Injuries

Advanced Healthcare Materials, EarlyView.
Catechol‐functionalized cellulose hydrogels are developed as injectable, bioadhesive platforms for retinal neuroprotection. The hydrogels exhibit tunable rheological and mechanical properties, strong tissue adhesion, and sustained antioxidative activity.
Kai‐Hsiang Chang, Yi‐Ke Lin, Wei‐Li Chen, Ta‐Ching Chen, Jiashing Yu   +4 more
wiley   +1 more source

The promoter for a variant surface glycoprotein gene expression site in Trypanosoma brucei. [PDF]

The EMBO Journal, 1990
The variant-specific surface glycoprotein (VSG) gene 221 of Trypanosoma brucei is transcribed as part of a 60 kb expression site (ES). We have identified the promoter controlling this multigene transcription unit by the use of 221 chromosome-enriched DNA libraries and VSG gene 221 expression site specific transcripts.
Zomerdijk, Joost C. B. M., Ouellette, Marc, ten Asbroek, Anneloor L. M. A., Kieft, Rudo, Bommer, Angeline M. M., Clayton, Christine E., Borst, Piet   +6 more
openaire   +3 more sources

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Base J and H3.V Regulate Transcriptional Termination in Trypanosoma brucei. [PDF]

PLoS Genetics, 2016
Trypanosoma brucei is a protozoan parasite that lacks many transcription factors found in other eukaryotes, such as those whose binding demarcates enhancers. T.
Danae Schulz, Maryam Zaringhalam, F Nina Papavasiliou, Hee-Sook Kim   +3 more
doaj   +1 more source

Selective cleavage of variant surface glycoproteins from Trypanosoma brucei [PDF]

Biochemical Journal, 1979
Two conformationally distinct regions were revealed by tryptic cleavage of six undenatured variant surface glycoproteins purified from clones of Trypanosoma brucei. Within 5 min, the native glycoproteins (65,000 mol.wt.) were cleaved, yielding a large N-terminal fragment (48,000-55,000 mol.wt.
J G, Johnson, G A, Cross
openaire   +2 more sources