Results 51 to 60 of about 2,182,609 (246)

Life and times:synthesis, trafficking, and evolution of VSG [PDF]

, 2014
Evasion of the acquired immune response in African trypanosomes is principally mediated by antigenic variation, the sequential expression of distinct variant surface glycoproteins (VSGs) at extremely high density on the cell surface.
Boehm, Cordula, Cordula Boehm, Senthil Kumar Natesan, Paul T. Manna, Ka Fai Leung, Natesan, Senthil Kumar, Field, Mark C., Leung, Ka Fai, Mark C. Field, Manna, Paul T.   +9 more
core   +1 more source

Intrahost HA polymorphisms and culture adaptation shape antigenic profiles of H3N2 influenza viruses

Journal of Virology
Accurate antigenic characterization of influenza viruses is critical for vaccine strain selection but is often confounded by intrahost genetic diversity and culture-induced adaptations.
Kritika Prasai, Zunlin Yang, Minhui Guan, Tao Li, Daphne Ware, Jun Hang, Xiu-Feng Wan   +6 more
doaj   +1 more source

A Novel Methodology for Detecting Variations in Cell Surface Antigens Using Cell-Tearing by Optical Tweezers

Biosensors, 2022
The quantitative analysis of cell surface antigens has attracted increasing attention due to the antigenic variation recognition that can facilitate early diagnoses.
Chih-Lang Lin, Shyang-Guang Wang, Meng-Tsung Tien, Chung-Han Chiang, Yi-Chieh Lee, Patrice L. Baldeck, Chow-Shing Shin   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Natural selection promotes antigenic evolvability. [PDF]

PLoS Pathogens, 2013
The hypothesis that evolvability - the capacity to evolve by natural selection - is itself the object of natural selection is highly intriguing but remains controversial due in large part to a paucity of direct experimental evidence.
Christopher J Graves, Vera I D Ros, Brian Stevenson, Paul D Sniegowski, Dustin Brisson   +4 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Antigenic variation and its evolution in P. falciparum malaria [PDF]

, 2014
This thesis investigates antigenic variation and its evolution in Plasmodium falciparum, the cause of the most deadly form of human malaria. Antigenic variation is a strategy for evading immunity by switching between antigenic variants during infection ...
Rob Noble (547749)
core   +1 more source

Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern.

PLoS Pathogens, 2011
Many pathogenic bacteria, fungi, and protozoa achieve chronic infection through an immune evasion strategy known as antigenic variation. In the human malaria parasite Plasmodium falciparum, this involves transcriptional switching among members of the var
Mario Recker, Caroline O Buckee, Andrew Serazin, Sue Kyes, Robert Pinches, Zóe Christodoulou, Amy L Springer, Sunetra Gupta, Chris I Newbold   +8 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source