Results 61 to 70 of about 2,182,609 (246)

Population structuring of multi-copy, antigen-encoding genes in Plasmodium falciparum

eLife, 2012
The coexistence of multiple independently circulating strains in pathogen populations that undergo sexual recombination is a central question of epidemiology with profound implications for control.
Yael Artzy-Randrup, Mary M Rorick, Karen Day, Donald Chen, Andrew P Dobson, Mercedes Pascual   +5 more
doaj   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Antigenic variation in Plasmodium falciparum

, 1991
Antigenic variation of infectious organisms is a major factor in evasion of the host immune response. However, there has been no definitive demonstration of this phenomenon in the malaria parasite Plasmodium falciparum.
Goozé, L, Biggs, BA, Wycherley, K, Southwell, B, Brown, ZV, Leech, JH, Wollish, W   +6 more
core   +1 more source

Emerging challenges in understanding trypanosome antigenic variation [PDF]

, 2017
Many pathogens evade host immunity by periodically changing the proteins they express on their surface — a phenomenon termed antigenic variation.
Papavasiliou, N, Schnaufer, Achim; id_orcid, Christina A. Cobbold, Cobbold, Christina A., Mugnier, Monica R., Monica R. Mugnier, Liam J. Morrison, Mugnier, Monica, Schnaufer, Achim, Figueiredo, Luisa, McCulloch, R, Andrew Jackson, Cobbold, CA, Schnaufer, A, Papavasiliou, Nina, Morrison, Liam; id_orcid, Matthews, K, Keith Matthews, Matthews, Keith; id_orcid, Morrison, LJ, Mugnier, MR, Richard McCulloch, Figueiredo, L, McCulloch, Richard, Jackson, Andrew, Morrison, Liam J., Nina Papavasiliou, Luisa Figueiredo, Achim Schnaufer, Matthews, Keith, Jackson, A   +30 more
core   +1 more source

Virulence and molecular adaptation of human urogenital mycoplasmas: a review

Biotechnology & Biotechnological Equipment, 2019
The pathogenesis of mycoplasmas requires their attachment to the epithelial mucosa membrane of the host cells, followed by colonisation and necrotic destruction of the submucosal tissue.
Orville Roachford, Karen Elizabeth Nelson, Bidyut Ranjan Mohapatra   +2 more
doaj   +1 more source

Antigenic analysis of classical swine fever virus E2 glycoprotein using pig antibodies identifies residues contributing to antigenic variation of the vaccine C-strain and group 2 strains circulating in China

Virology Journal, 2010
Background Glycoprotein E2, the immunodominant protein of classical swine fever virus (CSFV), can induce neutralizing antibodies and confer protective immunity in pigs.
Peng Jinrong, Li Xiaoliang, Yuan Xuemei, Wan Jing, Li Dejiang, Tong Chao, Chen Ning, Fang Weihuan   +7 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Antigenic variation in parasites

, 1984
Antigenic variation is a powerful survival strategy adapted by certain species of parasitic protozoa to allow them to survive in the immunized host. It is exemplified by the African trypanosomes, which provide far and away the best characterized and most
M.J. Turner
core   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source