Results 31 to 40 of about 306,691 (236)

The antigenic property of the H5N1 avian influenza viruses isolated in central China

Virology Journal, 2012
Background Three influenza pandemics outbroke in the last century accompanied the viral antigen shift and drift, resulting in the change of antigenic property and the low cross protective ability of the existed antibody to the newly emerged pandemic ...
Zou Wei, Ke Jianjiang, Zhu Jiping, Zhou Hongbo, Jin Meilin   +4 more
doaj   +1 more source

Resurgence and predominance of G3P[8] human rotaviruses in north-central Bangladesh, 2018–2019

New Microbes and New Infections, 2020
Predominance of genotype G3P[8] rotavirus was revealed for children and adults with diarrhoea in north-central Bangladesh for a 1-year period from September 2018.
R. Mazid, M.S. Aung, S.K. Paul, F.U. Ahmad, M. Alam, M.A. Ali, P. Nath, S. Ahmed, N. Haque, M.A. Hossain, N. Kobayashi   +10 more
doaj   +1 more source

Sequence-based antigenic change prediction by a sparse learning method incorporating co-evolutionary information. [PDF]

PLoS ONE, 2014
Rapid identification of influenza antigenic variants will be critical in selecting optimal vaccine candidates and thus a key to developing an effective vaccination program.
Jialiang Yang, Tong Zhang, Xiu-Feng Wan
doaj   +1 more source

Estimation of Reduction in Influenza Vaccine Effectiveness Due to Egg-Adaptation Changes—Systematic Literature Review and Expert Consensus

Vaccines, 2021
Background: Influenza vaccines are the main tool to prevent morbidity and mortality of the disease; however, egg adaptations associated with the choice of the manufacturing process may reduce their effectiveness.
Raul Ortiz de Lejarazu-Leonardo, Emanuele Montomoli, Radek Wojcik, Solomon Christopher, Anne Mosnier, Elena Pariani, Antoni Trilla Garcia, Helmut Fickenscher, Barbara C. Gärtner, Ravi Jandhyala, Maria Zambon, Catherine Moore   +11 more
doaj   +1 more source

Structural Consequences of Antigenic Variants of Human A/H3N2 Influenza Viruses

Viruses, 2023
The genetic basis of antigenic drift of human A/H3N2 influenza virus is crucial to understanding the constraints of influenza evolution and determinants of vaccine escape.
David Francis Burke
doaj   +1 more source

Estimating the impact of influenza vaccination and antigenic drift on influenza-related morbidity and mortality in England & Wales using hidden Markov models [PDF]

Influenza causes substantial morbidity and mortality in some influenza sea- sons, especially among the elderly. Influenza seasons dominated by circula- tion of influenza A/H3N2 virus tend to result in more morbidity and mor- tality than seasons ...
Mann, Andrea Gail
core   +1 more source

Computational Identification of Antigenicity-Associated Sites in the Hemagglutinin Protein of A/H1N1 Seasonal Influenza Virus.

PLoS ONE, 2015
The antigenic variability of influenza viruses has always made influenza vaccine development challenging. The punctuated nature of antigenic drift of influenza virus suggests that a relatively small number of genetic changes or combinations of genetic ...
Xiaowei Ren, Yuefeng Li, Xiaoning Liu, Xiping Shen, Wenlong Gao, Juansheng Li   +5 more
doaj   +1 more source

Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses

, 2011
Seasonal epidemics caused by influenza virus are driven by antigenic changes (drift) in viral surface glycoproteins that allow evasion from preexisting humoral immunity.
Xu, XiYan, Sandbulte, Mathew R., Gao, Jin, Fouchier, Ron; id_orcid, Russell, Colin A., Eichelberger, Maryna C., Burke, David F., Westgeest, Kim, Klimov, Alexander I., Smith, Derek   +9 more
core   +1 more source

Antigenic Drift in the Influenza

, 2022
"The relationship between influenza antigenic drift and vaccination is like the doomed love affair across time and space. Viruses are constantly flowing in nature, gradually accumulating mutations to escape the attack of antibodies; while antibodies are ...
Wang, Yiquan
core  

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source