Results 21 to 30 of about 13,481 (242)
Assessing Antigenic Drift of Seasonal Influenza A(H3N2) and A(H1N1)pdm09 Viruses. [PDF]
PLoS ONE, 2015 Under selective pressure from the host immune system, antigenic epitopes of influenza virus hemagglutinin (HA) have continually evolved to escape antibody recognition, termed antigenic drift.
Nipaporn Tewawong +8 more
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Patterns of predicted T-cell epitopes associated with antigenic drift in influenza H3N2 hemagglutinin. [PDF]
PLoS ONE, 2011 Antigenic drift allowing escape from neutralizing antibodies is an important feature of transmission and survival of influenza viruses in host populations.
E Jane Homan, Robert D Bremel
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Identification and Characterization of Novel Antibody Epitopes on the N2 Neuraminidase
mSphere, 2021 The influenza virus neuraminidase is an emerging target for universal influenza virus vaccines. However, in contrast to influenza virus hemagglutinin, we know little about antibody epitopes and antigenic sites on the neuraminidase.
Ericka Kirkpatrick Roubidoux +8 more
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Simulating antigenic drift and shift in influenza A [PDF]
Proceedings of the 2009 ACM symposium on Applied Computing, 2009 Computational models of the immune system and pathogenic agents have several applications, such as theory testing and validation, or as a complement to first stages of drug trials. One possible application is the prediction of the lethality of new Influenza A strains, which are constantly created due to antigenic drift and shift.
Nuno Fachada +2 more
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eLife, 2021 Seasonal coronaviruses (OC43, 229E, NL63, and HKU1) are endemic to the human population, regularly infecting and reinfecting humans while typically causing asymptomatic to mild respiratory infections.
Kathryn E Kistler, Trevor Bedford
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The antigenic evolution of influenza: drift or thrift? [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2013 It is commonly assumed that antibody responses against the influenza virus are polarized in the following manner: strong antibody responses are directed at highly variable antigenic epitopes, which consequently undergo ‘antigenic drift’, while weak antibody responses develop against conserved epitopes.
Wikramaratna, Paul S. +3 more
openaire +5 more sources
Influenza A gradual and epochal evolution: insights from simple models.
PLoS ONE, 2009 The recurrence of influenza A epidemics has originally been explained by a "continuous antigenic drift" scenario. Recently, it has been shown that if genetic drift is gradual, the evolution of influenza A main antigen, the haemagglutinin, is punctuated ...
Sébastien Ballesteros +2 more
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PLoS Computational Biology, 2023 Surface antigens of pathogens are commonly targeted by vaccine-elicited antibodies but antigenic variability, notably in RNA viruses such as influenza, HIV and SARS-CoV-2, pose challenges for control by vaccination. For example, influenza A(H3N2) entered
William T Harvey +8 more
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Integrating influenza antigenic dynamics with molecular evolution
eLife, 2014 Influenza viruses undergo continual antigenic evolution allowing mutant viruses to evade host immunity acquired to previous virus strains. Antigenic phenotype is often assessed through pairwise measurement of cross-reactivity between influenza strains ...
Trevor Bedford +9 more
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Glycosylation focuses sequence variation in the influenza A virus H1 hemagglutinin globular domain. [PDF]
PLoS Pathogens, 2010 Antigenic drift in the influenza A virus hemagglutinin (HA) is responsible for seasonal reformulation of influenza vaccines. Here, we address an important and largely overlooked issue in antigenic drift: how does the number and location of glycosylation ...
Suman R Das +5 more
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