Results 11 to 20 of about 13,481 (242)

The Molecular Basis for Antigenic Drift of Human A/H2N2 Influenza Viruses. [PDF]

J Virol, 2019
While influenza A viruses of subtype H2N2 were at the origin of the Asian influenza pandemic, little is known about the antigenic changes that occurred during the twelve years of circulation in humans, the role of preexisting immunity, and the evolutionary rates of the virus. In this study, the antigenic map derived from hemagglutination inhibition (HI)
Linster M, Schrauwen EJA, van der Vliet S, Burke DF, Lexmond P, Bestebroer TM, Smith DJ, Herfst S, Koel BF, Koel BF, Fouchier RAM.   +10 more
europepmc   +4 more sources

Antibody Immunodominance: The Key to Understanding Influenza Virus Antigenic Drift. [PDF]

Viral Immunol, 2018
Influenza A virus (IAV) imposes a significant socioeconomic burden on humanity. Vaccination is effective in only 60% of individuals, even under optimal circumstances. The difficulty stems from the remarkable ability of IAV to evade existing immunity.
Altman MO, Angeletti D, Yewdell JW.
europepmc   +4 more sources

Modeling Influenza Antigenic Shift and Drift with LEGO Bricks

Journal of Microbiology & Biology Education, 2016
The concepts of antigenic shift and drift could be found in almost every microbiology and virology syllabus, usually taught in the context of Influenza virus biology.
Boriana Marintcheva
doaj   +4 more sources

Antigenic Drift Defines a New D4 Subgenotype of Measles Virus. [PDF]

J Virol, 2017
ABSTRACT The measles virus hemagglutinin (MeV-H) protein is the main target of protective neutralizing antibodies. Using a panel of monoclonal antibodies (MAbs) that recognize known major antigenic sites in MeV-H, we identified a D4 genotype variant that escapes neutralization by MAbs targeting the neutralizing epitope (NE) antigenic site. By
Muñoz-Alía MÁ, Muller CP, Russell SJ.
europepmc   +4 more sources

Epitopes in the HA and NA of H5 and H7 avian influenza viruses that are important for antigenic drift [PDF]

FEMS Microbiology Reviews
Erica Spackman, JASMINA M Luczo, Spackman Erica   +2 more
exaly   +2 more sources

Antigenic drift expands influenza viral escape pathways from recalled humoral immunity [PDF]

Immunity
Daniel P Maurer, Aaron G Schmidt
exaly   +2 more sources

An Antigenic Thrift-Based Approach to Influenza Vaccine Design

Vaccines, 2021
The antigenic drift theory states that influenza evolves via the gradual accumulation of mutations, decreasing a host’s immune protection against previous strains. Influenza vaccines are designed accordingly, under the premise of antigenic drift. However,
Jai S. Bolton, Hannah Klim, Judith Wellens, Matthew Edmans, Uri Obolski, Craig P. Thompson   +5 more
doaj   +1 more source

Antigenic drift of hemagglutinin and neuraminidase in seasonal H1N1 influenza viruses from Saudi Arabia in 2014 to 2015 [PDF]

Journal of Medical Virology, 2020
Asif Naeem, Maaweya E Hamed, Mushira Enani   +2 more
exaly   +2 more sources

The role of genomics in tracking the evolution of influenza A virus. [PDF]

PLoS Pathogens, 2009
Influenza A virus causes annual epidemics and occasional pandemics of short-term respiratory infections associated with considerable morbidity and mortality.
Alice Carolyn McHardy, Ben Adams
doaj   +1 more source

Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution

eLife, 2020
Seasonal influenza virus A/H3N2 is a major cause of death globally. Vaccination remains the most effective preventative. Rapid mutation of hemagglutinin allows viruses to escape adaptive immunity. This antigenic drift necessitates regular vaccine updates.
John Huddleston, John R Barnes, Thomas Rowe, Xiyan Xu, Rebecca Kondor, David E Wentworth, Lynne Whittaker, Burcu Ermetal, Rodney Stuart Daniels, John W McCauley, Seiichiro Fujisaki, Kazuya Nakamura, Noriko Kishida, Shinji Watanabe, Hideki Hasegawa, Ian Barr, Kanta Subbarao, Pierre Barrat-Charlaix, Richard A Neher, Trevor Bedford   +19 more
doaj   +1 more source