Results 11 to 20 of about 53,295 (182)

Influenza Neuraminidase Characteristics and Potential as a Vaccine Target [PDF]

Frontiers in Immunology, 2021
Neuraminidase of influenza A and B viruses plays a critical role in the virus life cycle and is an important target of the host immune system. Here, we highlight the current understanding of influenza neuraminidase structure, function, antigenicity ...
Sarah Creytens, Xavier Saelens, Cornelis A. M. de Haan   +2 more
exaly   +4 more sources

Optimisation of Neuraminidase Expression for Use in Drug Discovery by Using HEK293-6E Cells

Viruses, 2021
Influenza virus is a highly contagious virus that causes significant human mortality and morbidity annually. The most effective drugs for treating influenza are the neuraminidase inhibitors, but resistance to these inhibitors has emerged, and additional ...
Ashley C. Campbell, John J. Tanner, Kurt L. Krause   +2 more
doaj   +1 more source

Pharmacoinformatics and Breed-Based De Novo Hybridization Studies to Develop New Neuraminidase Inhibitors as Potential Anti-Influenza Agents

Molecules, 2023
Influenza represents a profoundly transmissible viral ailment primarily afflicting the respiratory system. Neuraminidase inhibitors constitute a class of antiviral therapeutics employed in the management of influenza.
Bourougaa Lotfi, Ouassaf Mebarka, Bader Y. Alhatlani, Emad M. Abdallah, Sarkar M. A. Kawsar   +4 more
doaj   +1 more source

A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model

mBio, 2021
Current seasonal influenza virus vaccines do not induce robust immune responses to neuraminidase. Several factors, including immunodominance of hemagglutinin over neuraminidase, instability of neuraminidase in vaccine formulations, and variable ...
Shirin Strohmeier, Fatima Amanat, Xueyong Zhu, Meagan McMahon, Meagan E. Deming, Marcela F. Pasetti, Kathleen M. Neuzil, Ian A. Wilson, Florian Krammer   +8 more
doaj   +1 more source

Comparative Molecular Field Analysis (CoMFA), Molecular 1 Docking And ADMET Study on Thiazolidine-4-carboxylic acid 2 Derivatives as New Neuraminidase Inhibitors

Acta Chimica Slovenica, 2023
The objective of this research was to create a 3D-QSAR CoMFA model for a set of twenty-five  neuraminidase inhibitors containing thiazolidine-4-carboxylic acid derivatives and to identify  a new potent neuraminidase inhibitor for the treatment of ...
Lotfi Bourougaa, Mebarka Ouassaf, Shafi Ullah Khan   +2 more
doaj   +1 more source

Boost immunizations with NA-derived peptide conjugates achieve induction of NA inhibition antibodies and heterologous influenza protections

Cell Reports, 2023
Summary: Neuraminidase is suggested as an important component for developing a universal influenza vaccine. Targeted induction of neuraminidase-specific broadly protective antibodies by vaccinations is challenging.
De-Jian Liu, Cui-Cui Liu, Xiu-Qin Zhong, Xuan Wu, Hui-Hui Zhang, Shang-Wen Lu, Zhuo-Ling Shen, Wen-Wen Song, Shi-Long Zhao, You-Song Peng, He-Ping Zheng, Mu-Yang Wan, Yao-Qing Chen, Lei Deng   +13 more
doaj   +1 more source

Potential of Neuraminidase from Pasteurella multocida for Inhibiting Avian Influenza Virus Subtype H9N2 Replication In Ovo

Tropical Animal Science Journal, 2023
In recent decades, neuraminidase/sialidase-based antivirals have been produced to suppress respiratory viral infections, including avian influenza, which relies on sialic acid as the entry point for viruses into cells.
O. N. Poetri, C. M. H. Nugroho, O. S. M. Silaen, R. S. Kurnia, D. G. B. Krisnamurti, A. Indrawati, N. Hikmah, I. P. P. K. Hariyadi, M. A. Putra, A. Soebandrio   +9 more
doaj   +1 more source

Structural and functional relationship between the receptor recognition and neuraminidase activities of the Newcastle disease virus hemagglutinin-neuraminidase protein: Receptor recognition is dependent on neuraminidase activity [PDF]

, 2001
The terminal globular domain of the paramyxovirus hemagglutinin-neuraminidase (HN) glycoprotein spike has a number of conserved residues that are predicted to form its neuraminidase (NA) active site, by analogy to the influenza virus neuraminidase ...
Paul J. Mahon, Deng, R.T., Jennifer M. Sauvron, Langedijk, J.P., Anne M. Mirza, Gisela M. Field, Johannes P. Langedijk, Sauvron, J.M., Iorio, R.M., Field, G.M., Ruitang Deng, Mirza, A.M., Mahon, P.J., Ronald M. Iorio   +13 more
core   +1 more source

Screening of Influenza a (H1N1) Neuraminidase Inhibitor for Kabasura Kudineer, Nilavembu Kudineer and the Novel Formulation JACOM [PDF]

, 2021
Due to erratic climate change, vector-borne diseases started flaring up from the second half of the last decade. Siddha medicine has been used as a public health tool to effectively manage chikungunya and dengue in the epidemics that happened in 2008 and
Ramaswamy, RS, Dr SHREE, DEVI, Kadarkarai, Kanakavalli, SATHIYARAJESWARAN, P, SHREE DEVI, MS, Mohanasrinivasan, V, SUBATHRADEVI, C   +6 more
core   +1 more source

Effectiveness of neuraminidase inhibitors for preventing staff absenteeism during pandemic influenza. [PDF]

, 2007
We used a deterministic SEIR (susceptible-exposed-infectious-removed) meta-population model, together with scenario, sensitivity, and simulation analyses, to determine stockpiling strategies for neuraminidase inhibitors that would minimize absenteeism ...
Vernon J. Lee, Mark I. Chen, Lee, V.J, Chen, Mark I, Lee, Vernon J, Chen, M.I   +5 more
core   +1 more source