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Influenza neuraminidase mutations and resistance to neuraminidase inhibitors
Emerging Microbes & InfectionsMutations in influenza virus neuraminidase (NA) can lead to viral resistance to NA inhibitors (NAIs). To update global influenza NA mutations and resistance to NAIs, we investigated epidemic information from global regions for NAIs-resistant influenza strains and analyzed their NA mutations.
Jiapeng Xu +9 more
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Antivirals Targeting the Neuraminidase [PDF]
Cold Spring Harbor Perspectives in Medicine, 2020 The neuraminidase (NA) of influenza A and B viruses plays a distinct role in viral replication and has a highly conserved catalytic site. Numerous sialic (neuraminic) acid analogs that competitively bind to the NA active site and potently inhibit enzyme activity have been synthesized and tested.
Larisa, Gubareva, Teena, Mohan
openaire +3 more sources
mBio, 2017 Antibody responses to influenza virus hemagglutinin provide protection against infection and are well studied. Less is known about the human antibody responses to the second surface glycoprotein, neuraminidase. Here, we assessed human antibody reactivity
Madhusudan Rajendran +9 more
doaj +2 more sources
Neuraminidase Production by Clostridia [PDF]
Journal of Medical Microbiology, 1978 The production of neuraminidase (EC 3.2.1.18) by a range of clostridial species was investigated with techniques previously developed to distinguish neuraminidase-negative and neuraminidase-positive strains of Clostridium perfringens (welchii). Large amounts of extracellular neuraminidase were produced by representative strains of C. perfringens and C.
A. G. Fraser
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Neuraminidase Inhibitors for Influenza
New England Journal of Medicine, 2005 he impact of influenza infection is felt globally each year when the disease develops in approximately 20 percent of the world’s population. In the United States, influenza infections occur in epidemics each winter, generally between late December and early March. Recent events, including human cases of avian influenza, have heightened awareness of the
A. Moscona
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A pan-influenza antibody inhibiting neuraminidase via receptor mimicry
Nature, 2023 The neuraminidase-targeting monoclonal antibody FNI9 potently inhibits the enzymatic activity of influenza A and B viruses via receptor mimicry. Rapidly evolving influenza A viruses (IAVs) and influenza B viruses (IBVs) are major causes of recurrent ...
Corey Momont +34 more
semanticscholar +1 more source
Neuraminidase 1 promotes renal fibrosis development in male mice
Nature Communications, 2023 The functions of the influenza virus neuraminidase has been well documented but those of the mammalian neuraminidases remain less explored. Here, we characterize the role of neuraminidase 1 (NEU1) in unilateral ureteral obstruction (UUO) and folic acid ...
Qian-qian Chen +13 more
semanticscholar +1 more source
Pneumococcal Neuraminidase [PDF]
Journal of Bacteriology, 1966 Lee, L. T. (Columbia University, New York, N.Y.),and C. Howe. Pneumoccal neuraminidase. J. Bacteriol.91:1418–1426. 1966.—The elaboration of neuraminidase by pneumococci grown under optimal conditions in liquid medium was studied in relation to the bacterial growth cycle.
L T, Lee, C, Howe
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Neuraminidase 1 is a driver of experimental cardiac hypertrophy.
European Heart Journal, 2021 AIMS Despite considerable therapeutic advances, there is still a dearth of evidence on the molecular determinants of cardiac hypertrophy that culminate in heart failure. Neuraminidases are a family of enzymes that catalyze the cleavage of terminal sialic
Qian-qian Chen +13 more
semanticscholar +1 more source
Recent progress in chemical approaches for the development of novel neuraminidase inhibitors
RSC Advances, 2021 Influenza virus is the main cause of an infectious disease called influenza affecting the respiratory system including the throat, nose and lungs.
A. Mahal +10 more
semanticscholar +1 more source