Results 11 to 20 of about 102,895 (315)
Neuraminidase Inhibitors for Influenza
New England Journal of Medicine, 2005 he impact of influenza infection is felt globally each year when the disease develops in approximately 20 percent of the world’s population. In the United States, influenza infections occur in epidemics each winter, generally between late December and early March. Recent events, including human cases of avian influenza, have heightened awareness of the
Anne Moscona
exaly +4 more sources
Optimisation of Neuraminidase Expression for Use in Drug Discovery by Using HEK293-6E Cells
Viruses, 2021 Influenza virus is a highly contagious virus that causes significant human mortality and morbidity annually. The most effective drugs for treating influenza are the neuraminidase inhibitors, but resistance to these inhibitors has emerged, and additional ...
Ashley C. Campbell +2 more
doaj +1 more source
A pan-influenza antibody inhibiting neuraminidase via receptor mimicry
Nature, 2023 The neuraminidase-targeting monoclonal antibody FNI9 potently inhibits the enzymatic activity of influenza A and B viruses via receptor mimicry. Rapidly evolving influenza A viruses (IAVs) and influenza B viruses (IBVs) are major causes of recurrent ...
Corey Momont +34 more
semanticscholar +1 more source
Neuraminidase 1 promotes renal fibrosis development in male mice
Nature Communications, 2023 The functions of the influenza virus neuraminidase has been well documented but those of the mammalian neuraminidases remain less explored. Here, we characterize the role of neuraminidase 1 (NEU1) in unilateral ureteral obstruction (UUO) and folic acid ...
Qian-qian Chen +13 more
semanticscholar +1 more source
Molecules, 2023 Influenza represents a profoundly transmissible viral ailment primarily afflicting the respiratory system. Neuraminidase inhibitors constitute a class of antiviral therapeutics employed in the management of influenza.
Bourougaa Lotfi +4 more
doaj +1 more source
Pneumococcal Neuraminidase [PDF]
Journal of Bacteriology, 1966 Lee, L. T. (Columbia University, New York, N.Y.),and C. Howe. Pneumoccal neuraminidase. J. Bacteriol.91:1418–1426. 1966.—The elaboration of neuraminidase by pneumococci grown under optimal conditions in liquid medium was studied in relation to the bacterial growth cycle.
L T, Lee, C, Howe
openaire +2 more sources
Neuraminidase 1 is a driver of experimental cardiac hypertrophy.
European Heart Journal, 2021 AIMS Despite considerable therapeutic advances, there is still a dearth of evidence on the molecular determinants of cardiac hypertrophy that culminate in heart failure. Neuraminidases are a family of enzymes that catalyze the cleavage of terminal sialic
Qian-qian Chen +13 more
semanticscholar +1 more source
Cell Reports, 2023 Summary: Neuraminidase is suggested as an important component for developing a universal influenza vaccine. Targeted induction of neuraminidase-specific broadly protective antibodies by vaccinations is challenging.
De-Jian Liu +13 more
doaj +1 more source
A single residue substitution in the receptor-binding domain of H5N1 hemagglutinin is critical for packaging into pseudotyped lentiviral particles [PDF]
, 2012 © 2012 Tang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
AM Kilpatrick +49 more
core +16 more sources