Results 31 to 40 of about 140,304 (256)

Improved in vitro Efficacy of Baloxavir Marboxil Against Influenza A Virus Infection by Combination Treatment With the MEK Inhibitor ATR-002

Frontiers in Microbiology, 2021
Currently, all available antiviral drugs against influenza virus (IV) that target the virus proteins directly, like Baloxavir acid (BXA), lead to viral resistance.
Hazem Hamza, Hazem Hamza, Mahmoud M. Shehata, Mahmoud M. Shehata, Ahmed Mostafa, Ahmed Mostafa, Ahmed Mostafa, Stephan Pleschka, Stephan Pleschka, Oliver Planz   +9 more
doaj   +1 more source

Antiviral Resistance in Human Cytomegalovirus Due to UL54 Mutations Without UL97 Mutations

Annals of Clinical Microbiology, 2022
Background: The concurrent detection of human cytomegalovirus (CMV) with UL97 and UL54 mutations is crucial for prescribing adequate antiviral treatment when drug-resistant CMV infection is suspected.
Kuenyoul Park, Kyu-Hwa Hur, Heungsup Sung, Sang-Ho Choi, Mi-Na Kim   +4 more
doaj   +1 more source

Influenza antivirals: efficacy and resistance [PDF]

Influenza and Other Respiratory Viruses, 2012
The inaugural conference of the Antiviral Group of the International Society for Influenza and other Respiratory Virus Diseases (ISIRV-AVG) was organised in conjunction with the Oswaldo Cruz Foundation (FIOCRUZ) in Rio de Janeiro, Brazil, in November 2011.
Marilda, Siqueira, Alan, Hay
openaire   +2 more sources

Antivirals Targeting the Surface Glycoproteins of Influenza Virus: Mechanisms of Action and Resistance

Viruses, 2021
Hemagglutinin and neuraminidase, which constitute the glycoprotein spikes expressed on the surface of influenza A and B viruses, are the most exposed parts of the virus and play critical roles in the viral lifecycle.
Yaqin Bai, Jeremy C. Jones, Sook-San Wong, Mark Zanin   +3 more
doaj   +1 more source

The RNA-Binding Domain NS1 of Influenza as an Antiviral Target: From Evolutionary Conservation Mapping to Experimental Validation

Viruses
Non-structural protein 1 (NS1) of influenza A virus is a multifunctional virulence factor and represents a promising anti-influenza target, considering its conserved and druggable structure.
Luis André Santos, João Trigueiro-Louro, Helena Rebelo-de-Andrade   +2 more
doaj   +1 more source

Next-Generation Vaccines and Antiviral Platforms: Molecular Advancements in the Struggle against Emerging Zoonotic and Viral Diseases [PDF]

Archives of Razi Institute
The ongoing occurrence of zoonotic and viral diseases, such as SARS-CoV-2, H5N1, Nipah, and Ebola viruses, underscores the requirement for transformative innovations in vaccine and antiviral development.
Abdol Ebadi, Zeliha Selamoglu, Hamdia Issa, Elifsena Alp Arici, Shahid Abbas   +4 more
doaj   +1 more source

Whole genome analysis of hepatitis B virus before and during long-term therapy in chronic infected patients: Molecular characterization, impact on treatment and liver disease progression

Frontiers in Microbiology, 2022
Hepatitis B virus (HBV) infection remains a serious public health concern worldwide despite the availability of an efficient vaccine and the major improvements in antiviral treatments.
Zeineb Belaiba, Zeineb Belaiba, Kaouther Ayouni, Kaouther Ayouni, Mariem Gdoura, Mariem Gdoura, Wafa Kammoun Rebai, Henda Touzi, Amel Sadraoui, Walid Hammemi, Lamia Yacoubi, Salwa Abdelati, Lamine Hamzaoui, Mohamed Msaddak Azzouz, Anissa Chouikha, Anissa Chouikha, Henda Triki, Henda Triki   +17 more
doaj   +1 more source

Modeling Viral Infectious Diseases and Development of Antiviral Therapies Using Human Induced Pluripotent Stem Cell-Derived Systems

Viruses, 2015
The recent biotechnology breakthrough of cell reprogramming and generation of induced pluripotent stem cells (iPSCs), which has revolutionized the approaches to study the mechanisms of human diseases and to test new drugs, can be exploited to generate ...
Marta Trevisan, Alessandro Sinigaglia, Giovanna Desole, Alessandro Berto, Monia Pacenti, Giorgio Palù, Luisa Barzon   +6 more
doaj   +1 more source

Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and Resistance

Viruses, 2015
The hepatitis C virus (HCV) is a pandemic human pathogen posing a substantial health and economic burden in both developing and developed countries. Controlling the spread of HCV through behavioural prevention strategies has met with limited success and ...
Auda A. Eltahla, Fabio Luciani, Peter A. White, Andrew R. Lloyd, Rowena A. Bull   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source