Results 31 to 40 of about 2,451,260 (295)

Viral interferon antagonists and antiviral drugs [PDF]

, 2009
For this project, we developed reporter cell lines that express viral proteins with the potential to be used in cell-based screening assays to select chemical candidates for antiviral drugs.
Nobre, Rita
core   +2 more sources

Technical Validation of a Hepatitis C Virus Whole Genome Sequencing Assay for Detection of Genotype and Antiviral Resistance in the Clinical Pathway

Frontiers in Microbiology, 2020
Choice of direct acting antiviral (DAA) therapy for Hepatitis C Virus (HCV) in the United Kingdom and similar settings usually requires knowledge of the genotype and, in some cases, antiviral resistance (AVR) profile of the infecting virus.
Carmen F. Manso, David F. Bibby, Kieren Lythgow, Hodan Mohamed, Richard Myers, David Williams, Renata Piorkowska, Yuen T. Chan, Rory Bowden, M. Azim Ansari, M. Azim Ansari, Camilla L. C. Ip, Eleanor Barnes, Daniel Bradshaw, Jean L. Mbisa, Jean L. Mbisa   +15 more
doaj   +1 more source

Antiviral drug resistance as an adaptive process [PDF]

, 2021
Antiviral drug resistance is a matter of great clinical importance that, historically, has been investigated mostly from a virological perspective. Although the proximate mechanisms of resistance can be readily uncovered using these methods, larger ...
Renzette, Nicholas, Jensen, Jeffrey D., Kowalik, Timothy F., Irwin, Kristen K.   +3 more
core   +2 more sources

Improved in vitro Efficacy of Baloxavir Marboxil Against Influenza A Virus Infection by Combination Treatment With the MEK Inhibitor ATR-002

Frontiers in Microbiology, 2021
Currently, all available antiviral drugs against influenza virus (IV) that target the virus proteins directly, like Baloxavir acid (BXA), lead to viral resistance.
Hazem Hamza, Hazem Hamza, Mahmoud M. Shehata, Mahmoud M. Shehata, Ahmed Mostafa, Ahmed Mostafa, Ahmed Mostafa, Stephan Pleschka, Stephan Pleschka, Oliver Planz   +9 more
doaj   +1 more source

Participation of endogenous tumour necrosis factor α in host resistance to cytomegalovirus infection [PDF]

, 1993
Interferon gamma (IFN) represents an essential cytokine involved in murine cytomegalovirus (MCMV) clearance from the salivary gland and the control of horizontal transmission.
Crnkovic, Irena, Pavic, Ivica, Koszinowski, Ulrich H., Lucin, Pero, Polic, Bojan, Jonjic, Stipan   +5 more
core   +1 more source

Antiviral Resistance in Human Cytomegalovirus Due to UL54 Mutations Without UL97 Mutations

Annals of Clinical Microbiology, 2022
Background: The concurrent detection of human cytomegalovirus (CMV) with UL97 and UL54 mutations is crucial for prescribing adequate antiviral treatment when drug-resistant CMV infection is suspected.
Kuenyoul Park, Kyu-Hwa Hur, Heungsup Sung, Sang-Ho Choi, Mi-Na Kim   +4 more
doaj   +1 more source

Antiviral Agents: Discovery to Resistance [PDF]

Viruses, 2020
In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [...]
openaire   +4 more sources

The RNA-Binding Domain NS1 of Influenza as an Antiviral Target: From Evolutionary Conservation Mapping to Experimental Validation

Viruses
Non-structural protein 1 (NS1) of influenza A virus is a multifunctional virulence factor and represents a promising anti-influenza target, considering its conserved and druggable structure.
Luis André Santos, João Trigueiro-Louro, Helena Rebelo-de-Andrade   +2 more
doaj   +1 more source

Next-Generation Vaccines and Antiviral Platforms: Molecular Advancements in the Struggle against Emerging Zoonotic and Viral Diseases [PDF]

Archives of Razi Institute
The ongoing occurrence of zoonotic and viral diseases, such as SARS-CoV-2, H5N1, Nipah, and Ebola viruses, underscores the requirement for transformative innovations in vaccine and antiviral development.
Abdol Ebadi, Zeliha Selamoglu, Hamdia Issa, Elifsena Alp Arici, Shahid Abbas   +4 more
doaj   +1 more source

Informatics assisting influenza antiviral susceptibility monitoring in Europe [PDF]

, 2008
A web-based facility for collection, analysis and dissemination of influenza antiviral susceptibility data was successfully implemented. Its usefulness has been fully validated by the events of the 2007/2008 winter season when the emergence of high ...
P. Taylor, B. Lina, P. Pérez Brena, M. Zambon, F. Pregliasco, J. Paget, A. Hay, V. Enouf, A. Wiman, S. van der Werf, H. Rebelo de Andrade, A. Meijer, A. Lackenby   +12 more
core   +2 more sources