Results 21 to 30 of about 1,295 (151)

Interactions between HIV-1 reverse transcriptase and the downstream template strand in stable complexes with primer-template.

PLoS ONE, 2008
BackgroundHuman immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) forms stable ternary complexes in which RT is bound tightly at fixed positions on the primer-template (P/T). We have probed downstream interactions between RT and the template
Wiriya Rutvisuttinunt, Peter R Meyer, Walter A Scott   +2 more
doaj   +1 more source

Antiviral Resistance in Human Cytomegalovirus Due to UL54 Mutations Without UL97 Mutations

Annals of Clinical Microbiology, 2022
Background: The concurrent detection of human cytomegalovirus (CMV) with UL97 and UL54 mutations is crucial for prescribing adequate antiviral treatment when drug-resistant CMV infection is suspected.
Kuenyoul Park, Kyu-Hwa Hur, Heungsup Sung, Sang-Ho Choi, Mi-Na Kim   +4 more
doaj   +1 more source

The Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance

Viruses, 2010
Nucleoside reverse transcriptase (RT) inhibitors of HIV block viral replication through the ability of HIV RT to incorporate chain-terminating nucleotide analogs during viral DNA synthesis. Once incorporated, the chain-terminating residue must be removed
Walter A. Scott, Antonio J. Acosta-Hoyos
doaj   +1 more source

Effect of foscarnet induction treatment on quantitation of human cytomegalovirus (HCMV) DNA in blood leukocytes and aqueous humor of AIDS patients with HCMV retinitis

, 1994
The aim of this study was to investigate peripheral blood polymorphonuclear leukocytes and, whenever possible, aqueous humor from 65 AIDS patients with ophthalmoscopically diagnosed human cytomegalovirus (HCMV) retinitis to determine (i) whether patients
ZELLA D., BALDANTI F., ZIPETO, Donato, GERNA G., SARASINI A., PERCIVALLE E., REVELLO M. G., AND THE ITALIAN FOSCARNET STUDY GROUP, FURIONE M.   +8 more
core   +1 more source

Refractory human cytomegalovirus infection without evidence of genetic resistance in the UL-54 and UL-97 genes in a pediatric hematopoietic stem cell transplant recipient: a case report

Frontiers in Medicine
Cytomegalovirus (CMV) infection is a common complication in patients undergoing hematopoietic stem cell transplantation (HSCT). Management of refractory CMV infections, especially in developing countries, can be challenging due to the limited ...
Alejandra Pando-Caciano, Ketty Adid Escudero-Ramirez, Jackeline Carol Rodríguez-Torres, Holger Maita-Malpartida, Holger Maita-Malpartida   +4 more
doaj   +1 more source

Successful resolution of ganciclovir-resistant cytomegalovirus (CMV) retinitis with intravitreal foscarnet in a seronegative patient of psoriasis on immunosuppressive therapy

Indian Journal of Ophthalmology. Case Reports
We report an unusual case of intravitreal ganciclovir-resistant cytomegalovirus (CMVR) retinitis in a patient with psoriasis taking immunosuppressant medications, who responded to intravitreal foscarnet. A 37-year-old male patient presented with signs of
Debarati Dasgupta, Arkaprava Pradhan, S Sudharshan, Rajiv Raman, Jyotirmay Biswas   +4 more
doaj   +1 more source

Foscarnet eyedrops for the treatment of refractory herpetic keratitis

Journal of Ophthalmic Inflammation and Infection
Purpose The purpose of this case series is to describe the clinical course of patients receiving foscarnet eyedrops for the treatment of refractory herpetic keratitis.
Caroline C. Awh, Austen N. Knapp, Jeffrey M. Goshe, Craig W. See, Careen Y. Lowder   +4 more
doaj   +1 more source

ANZTCT cytomegalovirus practice survey for allogeneic haemopoietic stem cell transplant and cellular therapy recipients in Australia and New Zealand

Internal Medicine Journal, EarlyView.
Abstract Background Despite pre‐emptive treatment (PeT), cytomegalovirus (CMV) disease and reactivation remain a clinical concern. In Australia and New Zealand (ANZ), variability exists in the management of CMV for haematopoietic stem cell transplantation (HSCT) recipients.
Andrea Henden, Lynette Chee, Julia Clark, Rachel Conyers, Julian Cooney, Richard Doocey, David Gottlieb, Tim Prestidge, Madeleine Powys, Philip Selby, Gaurav Sutrave, Eric Wong, Michelle K. Yong, Nada Hamad   +13 more
wiley   +1 more source

Foscarnet-Associated Penile Ulcerations

, 1994
Objective: To report a case of foscarnet-induced penile ulcerations and review literature related to this adverse effect. Data Sources: Case reports and review articles identified by a computerized search (MEDLINE) and manual search (Index Medicus). Data
Richard M. Cadle, Richard J. Hamill
core   +1 more source

KSHV Targeted Therapy: An Update on Inhibitors of Viral Lytic Replication

Viruses, 2014
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi’s sarcoma, primary effusion lymphoma and multicentric Castleman’s disease.
Natacha Coen, Sophie Duraffour, Robert Snoeck, Graciela Andrei   +3 more
doaj   +1 more source