Results 21 to 30 of about 5,811 (157)

Foscarnet Therapy for Pure Red Cell Aplasia Related to Human Parvovirus B19 Infection in Kidney Transplant Recipients: A Preliminary Exploration

Infection and Drug Resistance, 2021
Yedong Yu,1 Ruijie Bao,1 Junhao Lyu,1– 4 Jianyong Wu,1– 4 Jianghua Chen,1– 4 Wenhan Peng1– 4 1Department of Kidney Disease Center, The First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 2Department of ...
Yu Y, Bao R, Lyu J, Wu J, Chen J, Peng W
doaj  

Interactions between HIV-1 reverse transcriptase and the downstream template strand in stable complexes with primer-template.

PLoS ONE, 2008
BackgroundHuman immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) forms stable ternary complexes in which RT is bound tightly at fixed positions on the primer-template (P/T). We have probed downstream interactions between RT and the template
Wiriya Rutvisuttinunt, Peter R Meyer, Walter A Scott   +2 more
doaj   +1 more source

Antiviral Resistance in Human Cytomegalovirus Due to UL54 Mutations Without UL97 Mutations

Annals of Clinical Microbiology, 2022
Background: The concurrent detection of human cytomegalovirus (CMV) with UL97 and UL54 mutations is crucial for prescribing adequate antiviral treatment when drug-resistant CMV infection is suspected.
Kuenyoul Park, Kyu-Hwa Hur, Heungsup Sung, Sang-Ho Choi, Mi-Na Kim   +4 more
doaj   +1 more source

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review. [PDF]

Clin Pharmacol Ther
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Alatawi W, Wallace JL, Rungkitwattanakul D, Stottlemyer BA, Tran TL, Reida MM, Kane-Gill SL.   +6 more
europepmc   +2 more sources

The Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance

Viruses, 2010
Nucleoside reverse transcriptase (RT) inhibitors of HIV block viral replication through the ability of HIV RT to incorporate chain-terminating nucleotide analogs during viral DNA synthesis. Once incorporated, the chain-terminating residue must be removed
Walter A. Scott, Antonio J. Acosta-Hoyos
doaj   +1 more source

Refractory human cytomegalovirus infection without evidence of genetic resistance in the UL-54 and UL-97 genes in a pediatric hematopoietic stem cell transplant recipient: a case report

Frontiers in Medicine
Cytomegalovirus (CMV) infection is a common complication in patients undergoing hematopoietic stem cell transplantation (HSCT). Management of refractory CMV infections, especially in developing countries, can be challenging due to the limited ...
Alejandra Pando-Caciano, Ketty Adid Escudero-Ramirez, Jackeline Carol Rodríguez-Torres, Holger Maita-Malpartida, Holger Maita-Malpartida   +4 more
doaj   +1 more source

Successful resolution of ganciclovir-resistant cytomegalovirus (CMV) retinitis with intravitreal foscarnet in a seronegative patient of psoriasis on immunosuppressive therapy

Indian Journal of Ophthalmology. Case Reports
We report an unusual case of intravitreal ganciclovir-resistant cytomegalovirus (CMVR) retinitis in a patient with psoriasis taking immunosuppressant medications, who responded to intravitreal foscarnet. A 37-year-old male patient presented with signs of
Debarati Dasgupta, Arkaprava Pradhan, S Sudharshan, Rajiv Raman, Jyotirmay Biswas   +4 more
doaj   +1 more source

Foscarnet eyedrops for the treatment of refractory herpetic keratitis

Journal of Ophthalmic Inflammation and Infection
Purpose The purpose of this case series is to describe the clinical course of patients receiving foscarnet eyedrops for the treatment of refractory herpetic keratitis.
Caroline C. Awh, Austen N. Knapp, Jeffrey M. Goshe, Craig W. See, Careen Y. Lowder   +4 more
doaj   +1 more source

Prospective Study of Targeted Busulfan–Fludarabine Conditioning for Hematopoietic Stem Cell Transplantation in Genetic Rare Diseases

European Journal of Haematology, EarlyView.
ABSTRACT Objectives Genetic rare diseases (GRDs), including chronic granulomatous disease, familial hemophagocytic lymphohistiocytosis, and congenital neutropenia, often require hematopoietic stem cell transplantation (HSCT) as the only curative option.
Bo Kyung Kim, Kyung Taek Hong, Jung Yoon Choi, Hyun Jin Park, Kyung‐Sang Yu, In‐Jin Jang, Hyoung Jin Kang   +6 more
wiley   +1 more source

KSHV Targeted Therapy: An Update on Inhibitors of Viral Lytic Replication

Viruses, 2014
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi’s sarcoma, primary effusion lymphoma and multicentric Castleman’s disease.
Natacha Coen, Sophie Duraffour, Robert Snoeck, Graciela Andrei   +3 more
doaj   +1 more source