Variability in antifungal and antiviral use in hospitalized children [PDF]
, 2017 We analyzed antifungal and antiviral prescribing among high-risk children across freestanding children’s hospitals. Antifungal and antiviral days of therapy varied across hospitals.
Gerber, Jeffrey S +6 more
core +2 more sources
A randomized, controlled trial comparing ganciclovir to ganciclovir plus foscarnet (each at half dose) for preemptive therapy of cytomegalovirus infection in transplant recipients [PDF]
, 2004 Forty-eight patients who provided 2 consecutive blood samples that tested positive for cytomegalovirus DNA by polymerase chain reaction (PCR) were randomized to receive either full-dose ganciclovir ( 5 mg/kg intravenously [iv] twice daily) or half-dose ...
Amooty, G +15 more
core +1 more source
Case Reports in Ophthalmology, 2022 This is a report of an immunocompromised 49-year-old renal transplant patient with Epstein-Barr virus (EBV)-induced necrotizing retinitis (NR). The patient with NR underwent diagnostic vitrectomy.
Junsang Cho +5 more
doaj +1 more source
The Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance
Viruses, 2010 Nucleoside reverse transcriptase (RT) inhibitors of HIV block viral replication through the ability of HIV RT to incorporate chain-terminating nucleotide analogs during viral DNA synthesis. Once incorporated, the chain-terminating residue must be removed
Walter A. Scott, Antonio J. Acosta-Hoyos
doaj +1 more source
Impact of IFN lambda 3/4 single nucleotide polymorphisms on the cytomegalovirus reactivation in autologous stem cell transplant patients [PDF]
, 2018 Cytomegalovirus (CMV) infection represents one of the main cause mortality after Stem Cell Transplantation. Recently, a protective effect of the T allele of rs12979860 IL28B Single Nucleotide Polymorphisms (SNPs) against CMV infection in the allogenic ...
Angeletti, S +13 more
core +1 more source
Case Reports in Transplantation, 2017 Background. Cytomegalovirus (CMV) antiviral drug resistance constitutes an increasing challenge in transplantation. Foscarnet is usually proposed when resistance for ganciclovir is suspected, but its use is limited by its nephrotoxicity.
Romain Vial +9 more
doaj +1 more source
Antiviral Resistance in Human Cytomegalovirus Due to UL54 Mutations Without UL97 Mutations
Annals of Clinical Microbiology, 2022 Background: The concurrent detection of human cytomegalovirus (CMV) with UL97 and UL54 mutations is crucial for prescribing adequate antiviral treatment when drug-resistant CMV infection is suspected.
Kuenyoul Park +4 more
doaj +1 more source
Conformational states of HIV-1 reverse transcriptase for nucleotide incorporation vs. pyrophosphorolysis – binding of foscarnet [PDF]
, 2016 HIV-1 reverse transcriptase (RT) catalytically incorporates individual nucleotides into a viral DNA strand complementing an RNA or DNA template strand; the polymerase active site of RT adopts multiple conformational and structural states while performing
Arnold, Eddy +5 more
core +2 more sources
Infection and Drug Resistance, 2021 Yedong Yu,1 Ruijie Bao,1 Junhao Lyu,1– 4 Jianyong Wu,1– 4 Jianghua Chen,1– 4 Wenhan Peng1– 4 1Department of Kidney Disease Center, The First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 2Department of ...
Yu Y, Bao R, Lyu J, Wu J, Chen J, Peng W
doaj
Analysis of cytomegalovirus resistance mutations and clinical features of CMV infection in immunocompromised children [PDF]
Клиническая микробиология и антимикробная химиотерапияObjective. To determine frequency and spectrum of cytomegalovirus (CMV) resistance mutations to antiviral drugs in immunocompromised children. To study clinical course of resistant CMV infection in this patient population. Materials and Methods. This
Kozhushnaya O.S. +4 more
doaj +1 more source