Results 21 to 30 of about 6,386 (141)

GCV-resistant CMV treated by foscarnet

, 2016
Cytomegalovirus (CMV) infection is themost common infectious complication following solid organ transplantation. Ganciclovir (GCV)-resistant CMV infection may be fatal, and is difficult to treat while avoiding allograft rejection.
Morita, Ken, Oishi, Yuichiro, Fujita, Hiromi, Iwami, Daiki, Shinohara, Nobuo, Ogawa, Yayoi, Sasaki, Hajime, Higuchi, Haruka, Hatanaka, Kanako   +8 more
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Congenital CMV Infection: Determination of Transplacental Passage of Aciclovir by Ex Vivo Placental Perfusion

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 6, Page 1241-1248, May 2026.
ABSTRACT Objective To quantify the transplacental transfer of aciclovir at an amount equivalent to 2 g of valaciclovir corresponding to the fractionated dosing regimen given four times daily used to reduce congenital cytomegalovirus (CMV) transmission and to treat the CMV‐infected fetus. Design Experimental ex vivo study.
Helyett Ollivier, Valentine Faure Bardon, Leo Froelicher Bournaud, Isidore Gaubert, Tiffany Guilleminot, Marianne Leruez‐Ville, Jean‐Marc Treluyer, Yves Ville, Gabrielle Lui, Julien Stirnemann   +9 more
wiley   +1 more source

Fatal Chronic Varicella‐Zoster Viral Infection in a Young Man With Chediak–Higashi Syndrome

Pediatric Dermatology, Volume 43, Issue 3, Page 706-710, May/June 2026.
ABSTRACT Chediak–Higashi syndrome (CHS) is a rare autosomal recessive primary immunodeficiency characterized by partial oculocutaneous albinism, neurologic involvement, and a predisposition to severe infections. Patients are particularly susceptible to developing hemophagocytic lymphohistiocytosis (HLH), which significantly worsens prognosis. We report
Albane Badet, Clément Pruvot, Zoé Manssens, Wadih Abou‐Chahla, Sébastien Buche   +4 more
wiley   +1 more source

33111 New onset scrotal lesions in a patient with herpes simplex virus treated with foscarnet

, 2022
Introduction: Intravenous (IV) foscarnet is used for the treatment of acyclovir-resistant herpes simplex virus (HSV). Foscarnet-induced penile ulcerations, thought to be due to an irritant contact dermatitis, can occur where urine contacts the skin, such
Wang, Rebecca F, Friedman, Ben J
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Morbidity and Toxic Effects Associated With Ganciclovir or Foscarnet Therapy in a Randomized Cytomegalovirus Retinitis Trial

, 1995
BACKGROUND: The Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial compared the use of either ganciclovir or foscarnet for the initial treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome.
Conway, Brian, Jacobson, Mark, Kimbrell, Chris, Apuzzo, Linda, Fainstein, Victor, Jabs, Douglas A, Meinert, Curtis L, Collison, Betty J, Clark, Tom, Henderly, Dale, Dieterich, Douglas, Lewis, Richard A, Nussenblatt, Robert, Klemm, Amy C, Grizzle, James, Fink, Nancy, Rickman, Leland, Feinberg, Judith, Vandenbroucke, Ruth, Thomas, Suzanne, Mowery, Richard, Jampol, Lee, Saah, A, Freitag, Ginger, Sacks, Henry, Kachadoorian, Harry, Samo, Tobias, Mendez, Paul, Ellenberg, Susan, Webb, Rene, Holbrook, Janet T, Brothers, Rosemary, Frost, Kevin, MacArthur, Lesley J, Seiff, Stuart, Hubbard, Larry, Binder, Karen L, Coleson, Laura, Gerczak, Charlotte, Larson, James, Gross, Ronald, Leslie, Jo, Freeman, William R, Gittinger, John, Meinert, J. L, Peyman, Gholam, Jordan, Colin, Bartlett, John, Espinal, Millie, Korvick, Joyce, Dodge, John, Isaacson, Milana R, Holland, Gary N, Hurlburt, Dolores, Hoffman, Jacqueline, Brown-Bellamy, Jude, Davis, Janet, Kline, Joan M, Min, Yuan-I, Van Natta, Mark L, Simanello, Mary Ann, Barron, Bruce, Agres-Segal, Maria, Miner, Kathleen, O'Donnell, James, Quiceno, Jose I, Franklin, Rudolph, Markowitz, Jan A, Magli, Yvonne, Wise-Campbell, Susanne, Smith, Michael, Cheung, Tony W, Tuttle, Colette, Hardy, W. David, Sandford, Gordon R, Sternberg, Alice L, Teich, Steven, Friedberg, Dorothy N, Freeman, William, Owens, Rosetta M, Davis, Matthew D, Eldred, Lois, Stewart, Gary, Heinemann, Murk-Hein, Haubrich, Richard, Cheeseman, Sarah H, Brown, Vivian E, Meixnert, Linda, Peterson, Timothy J, Armstrong, Jane, Vanderhoof-Young, Marilyn, Mills, John, Naughton, Kathleen, Jones, Camara P, Polsky, Bruce, Friedman, Alan H, Welch, Lisa, Spector, Stephen, Severin, Colette, Levine, Charlene R, Hughes, Robert, Justin, Norma, Singer, Stephen, Kastorff, Linda, Greenspan, Deborah, Nowakowski, Deborah J, Tolson, Karen, Dunn, J. P, Clogston, Pamela, Chuang, Elaine, Smith, Harmon, Clogston, Pamela S, Chafey, Suzette, Squires, Kathleen, Brookmeyer, Ronald, Flynn, Thomas, Addessi, Adrienne, King, Rosemary, Tonascia, James, Brown, Byron W, Sattler, Fred, Irvine, Alexander, Murphy, Robert, Donithan, Michele, Phair, John, Le-Count, Cynthia, Weinberg, David, Wanner, Maxine, Fall, Holly, Stevens, Maria   +129 more
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Brincidofovir Use after Foscarnet Crystal Nephropathy in a Kidney Transplant Recipient with Multiresistant Cytomegalovirus Infection [PDF]

, 2017
Background. Cytomegalovirus (CMV) antiviral drug resistance constitutes an increasing challenge in transplantation. Foscarnet is usually proposed when resistance for ganciclovir is suspected, but its use is limited by its nephrotoxicity.
Purgus, Raj, Jourde-Chiche, Noemie, Sophie Alain, Valérie Moal, Decourt, Alexandre, Charleric Bornet, Christine Zandotti, Legris, Tristan, Laurent Daniel, Alain, Sophie, Vial, Romain, Bornet, Charléric, Moal, Valerie, Alexandre Decourt, Tristan Legris, Romain Vial, Noémie Jourde-Chiche, Zandotti, Christine, Daniel, Laurent, Raj Purgus   +19 more
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Sensitive and Rapid Dual One‐Tube Recombinase Aided PCR Assays for the Simultaneous Detection of Cytomegalovirus, Epstein‐Barr Virus, Human Herpesvirus 6, and Herpes Simplex Virus 1/2 in Whole Blood From Children Undergoing Hematopoietic Stem Cell Transplantation

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Early, rapid, and sensitive detection of cytomegalovirus (CMV), Epstein‐Barr virus (EBV), human herpesvirus 6 (HHV‐6), and herpes simplex virus Types 1/2 (HSV‐1/2) is critical for improving clinical outcomes in pediatric hematopoietic stem cell transplantation (HSCT).
Li Zhao, Mengchuan Zhao, Yuan Gao, Yanqing Tie, Yinghui Guo, Shuai Zhang, Yuxin Wang, Deran Ma, Zhili Shao, Zhishan Feng   +9 more
wiley   +1 more source

Characterisation of Foscarnet-Resistant Strains of Human Immunodeficiency Virus Type 1

, 1995
Foscarnet is a broad spectrum viral DNA polymerase inhibitor active in vitro and in vivo against human immunodeficiency virus type 1 (HIV-1). Strains of HIV-1 resistant to foscarnet were selected by in vitro passage in increasing concentrations of drug ...
Gurusinghe, Asitha D., Bazmi, Hengameh, Hooker, David J., Tachedjian, Gilda, Deacon, Nicholas J., Mellors, John, Mills, John, Birch, Chris   +7 more
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A Novel Modified Bu/Vp16/cy/Flu/Ara‐C Conditioning Regimen Enhances Outcomes for High‐Risk Acute Lymphoblastic Leukemia Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Purpose Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) effectively treats high‐risk acute lymphoblastic leukemia (ALL), yet challenges persist due to post‐transplant relapse and conditioning regimen toxicities. The determination of an appropriate preconditioning regimen is critical to improving patient outcomes.
Xiaoyan Zhao, Yifan Yao, Yan Sun, Ziwei Xu, Aiguo Liu, Xin Dong, Huafang Wang   +6 more
wiley   +1 more source

Minimising the Dosage-Limiting Toxicities of Foscarnet Induction Therapy

, 1997
This article suggests ways to manage the dose-limiting adverse reactions caused by foscarnet so that this agent may be used with confidence as first-line therapy in patients with cytomegalovirus (CMV) disease.Foscarnet (trisodium phosphonoformate) has ...
Jayaweera, Dushyantha
core   +1 more source