Results 31 to 40 of about 5,811 (157)

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, Volume 13, Issue 44, 7 August 2026.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Surveillance of CMV Terminase Gene Mutations in Allogeneic Hematopoietic Stem Cell Transplant Recipients Receiving Letermovir Prophylaxis

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT Letermovir (LMV), a CMV‐specific terminase inhibitor, is recommended for cytomegalovirus (CMV) prophylaxis in CMV‐seropositive allogeneic hematopoietic stem cell transplant (alloHSCT) recipients. The association between low‐level CMV DNAemia during prophylaxis and the emergence of mutations in CMV terminase complex genes remains unclear.
Amandine Caillault, Alienor Xhaard, Severine Mercier‐Delarue, Linda Feghoul, Julien Robert, Nathalie Schnepf, David Michonneau, Marie Robin, Flore Sicre de Fontbrune, Eleonore Kaphan, Mathilde Ruggiu‐Goiran, Pedro Henrique de Lima Prata, Florian Chevillon, Matthieu Jestin, Nathalie Dhedin, Gerard Socie, Régis Peffault de Latour, Maud Salmona, Jérôme LeGoff   +18 more
wiley   +1 more source

Primary treatment failure in acute retinal necrosis – A comprehensive review

Indian Journal of Ophthalmology
Acute retinal necrosis (ARN) is a sight-threatening ophthalmic emergency that requires aggressive treatment to prevent irreversible vision loss. However, primary treatment failure (PTF), where the initial antiviral therapy is ineffective, is a common ...
Ankush Kawali, Aayesha Khanum, Sai B Mishra, Srinivasan Sanjay, Padmamalini Mahendradas   +4 more
doaj   +1 more source

Role of Phosphorus-Containing Molecules on the Formation of Nano-Sized Calcium Phosphate for Bone Therapy

Frontiers in Bioengineering and Biotechnology, 2022
Calcium phosphate (CaP) is the principal inorganic constituent of bone and teeth in vertebrates and has various applications in biomedical areas. Among various types of CaPs, amorphous calcium phosphate (ACP) is considered to have superior bioactivity ...
Yingying Jiang, Yingying Jiang, Yali Tao, Yutong Chen, Xu Xue, Gangyi Ding, Sicheng Wang, Sicheng Wang, Guodong Liu, Mengmeng Li, Jiacan Su, Jiacan Su   +11 more
doaj   +1 more source

Advancing Antiviral Design: Integrating Natural Products, Computation and Targeted Delivery

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
A stepwise translational framework linking natural‐product discovery, computational prioritisation, experimental validation, lead optimisation and targeted delivery is proposed to advance antiviral design. ABSTRACT The COVID‐19 pandemic highlighted the role of rapid viral mutation and global connectivity in accelerating viral emergence and spread ...
Adedayo Ayodeji Lanrewaju, Abimbola Motunrayo Folami, Saheed Sabiu, Feroz Mahomed Swalaha   +3 more
wiley   +1 more source

Progress and Challenges in the Management of Congenital Cytomegalovirus Infection

Clinics and Practice
Congenital cytomegalovirus (CMV) infection is the most common intrauterine viral infection with a significant impact on the foetus and newborn. Current diagnostic practice includes serological testing for specific antibodies, but there are no global ...
Weronika Szulc, Natalia Szydłowska, Julia M. Smyk, Anna Majewska   +3 more
doaj   +1 more source

European Recommendations for Transitioning the Care of Patients With Multiple Myeloma Treated With B‐Cell Maturation Antigen Bispecific Antibodies From Academic Hospitals to Community‐Based Centers and for Outpatient Step‐Up Dosing

eJHaem, Volume 7, Issue 3, June 2026.
ABSTRACT Introduction Safe outpatient delivery of B‐cell maturation antigen–targeting bispecific antibodies (BCMA‐BsAbs) in multiple myeloma (MM) is challenging, particularly during step‐up dosing (SUD). Standardized guidance for European community practice is limited.
María‐Victoria Mateos, Elena Zamagni, Massimo Gentile, Rachel Hall, Florence Lachenal, Mónica López Riñon, Rakesh Popat, Christof Scheid, Thomas Wolff, Isabel Perez‐Cruz, Mohamad Mohty   +10 more
wiley   +1 more source

Protective Effect of Vitamin E Against Vancomycin‐Induced Nephrotoxicity: A Large‐Scale Electronic Medical Record Study From Japan

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 6, June 2026.
ABSTRACT Vancomycin (VCM) is essential for treating methicillin‐resistant Staphylococcus aureus infections, but its use is limited by vancomycin‐induced nephrotoxicity (VIN). Although preclinical and small clinical studies suggest a protective role for vitamin E, real‐world evidence remains limited.
Satoru Nakanishi, Shungo Imai, Megumi Saito, Hayato Kizaki, Haru Iino, Masami Tsuchiya, Satoko Hori   +6 more
wiley   +1 more source

A case of Epstein-Barr virus acute retinal necrosis successfully treated with foscarnet

American Journal of Ophthalmology Case Reports, 2022
Purpose: Epstein-Barr virus (EBV) is a herpes virus known to cause infectious mononucleosis and several other human disorders. Ocular EBV infections that have been reported include uveitis, retinal vasculitis, and acute retinal necrosis (ARN).
Kayo Suzuki, Kenichi Namba, Keitaro Hase, Kazuomi Mizuuchi, Daiju Iwata, Takako Ito, Nobuyoshi Kitaichi, Hiroshi Takase, Susumu Ishida   +8 more
doaj   +1 more source

Maribavir for Cytomegalovirus Infection in High‐Risk Kidney Transplant Recipients: A Case Series

IJU Case Reports, Volume 9, Issue 3, May 2026.
ABSTRACT Background Cytomegalovirus (CMV) infection remains a common complication after kidney transplantation, particularly among high‐risk donor‐seropositive/recipient‐seronegative (D+/R−) recipients. Valganciclovir is the standard first‐line therapy; however, its use may be limited by hematological toxicity or impaired graft function. Maribavir is a
Daiji Takamoto, Yu Shimada, Yuri Hasegawa, Takeaki Noguchi, Takashi Kawahara, Junichi Teranishi, Kazuhide Makiyama   +6 more
wiley   +1 more source