Results 11 to 20 of about 2,726 (170)

An Enzymatic Flow-Based Preparative Route to Vidarabine [PDF]

Molecules, 2020
The bi-enzymatic synthesis of the antiviral drug vidarabine (arabinosyladenine, ara-A), catalyzed by uridine phosphorylase from Clostridium perfringens (CpUP) and a purine nucleoside phosphorylase from Aeromonas hydrophila (AhPNP), was re-designed under ...
Teodora Bavaro, Andrea Pinto, Lucia Tamborini   +2 more
exaly   +6 more sources

Vidarabine, an anti-herpes agent, improves Porphyromonas gingivalis lipopolysaccharide-induced cardiac dysfunction in mice [PDF]

Journal of Physiological Sciences, 2023
In this work, we examined the involvement of type 5 adenylyl cyclase (AC5) in cardiac dysfunction induced in mice given Porphyromonas gingivalis lipopolysaccharide (PG-LPS) at a dose equivalent to the circulating levels in periodontitis (PD) patients ...
Michinori Tsunoda, Ichiro Matsuo, Yoshiki Ohnuki, Kenji Suita, Misao Ishikawa, Takao Mitsubayashi, Aiko Ito, Yasumasa Mototani, Kenichi Kiyomoto, Akinaka Morii, Megumi Nariyama, Yoshio Hayakawa, Kazuhiro Gomi, Satoshi Okumura   +13 more
doaj   +3 more sources

Water-soluble vidarabine derivatives alleviate catecholamine-induced heart failure and arrhythmia without impairing cardiac function in mice. [PDF]

PLoS ONE
The worldwide standard guideline for treating heart failure (HF) is inhibition of the patients' chronically enhanced sympathetic nervous system activity.
Kenji Suita, Yoshio Hayakawa, Yujiro Hoshino, Wenqian Cai, Reiko Kurotani, Yoshiki Ohnuki, Yasumasa Mototani, Yoshihiro Ishikawa, Satoshi Okumura   +8 more
doaj   +3 more sources

Exploring the anticancer activities of Sulfur and magnesium oxide through integration of deep learning and fuzzy rough set analyses based on the features of Vidarabine alkaloid [PDF]

Scientific Reports
Drug discovery and development is a challenging and time-consuming process. Laboratory experiments conducted on Vidarabine showed IC50 6.97 µg∕mL, 25.78 µg∕mL, and ˃ 100 µg∕mL against non-small Lung cancer (A-549), Human Melanoma (A-375), and Human ...
Heba Askr, Marwa A. A. Fayed, Heba Mamdouh Farghaly, Mamdouh M. Gomaa, Enas Elgeldawi, Yaseen A. M. M. Elshaier, Ashraf Darwish, Aboul Ella Hassanien   +7 more
doaj   +3 more sources

Acyclovir Encephalopathy in HSV Encephalitis Elderly With Normal Renal Function [PDF]

Case Reports in Neurological Medicine
Herpes simplex virus (HSV) encephalitis is a disease treated with acyclovir (ACV). However, the neurotoxicity of ACV can lead to the development of ACV encephalopathy.
Naoko Makishi, Yasuharu Tokuda
doaj   +3 more sources

Overcoming post‐transplant graft failure and adenovirus infection in a patient with FLT3‐TKD‐mutated mixed‐phenotype acute leukemia: A case report [PDF]

eJHaem
Mixed‐phenotype acute leukemia (MPAL) with FLT3‐TKD mutations is a rare and challenging subtype of leukemia. Effective management strategies are crucial for improving patient outcomes.
Yusuke Takada, Shuhei Kurosawa, Toshimitsu Ueki, Yuho Najima, Satoshi Wakita, Hiroki Yamaguchi, Takako Yokota, Masaki Hibi, Ayumi Hirahara, Tsutomu Yoshida, So Okubo, Moe Masuda, Hitomi Nakayama, Aki Sakurai, Chisako Ito, Yoshinobu Aisa, Tomonori Nakazato   +16 more
doaj   +3 more sources

SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of vidarabine against rotenone-induced neural cell injury [PDF]

Heliyon, 2023
Parkinson's disease (PD) is the second most common neurodegenerative disease in the world, which is distinguished by the loss of dopaminergic (DA) neurons in the substantia nigra and the formation of intraneuronal. Numerous studies showed that the damage
Lanxin Li, Yang Zhang, Zhengqian Chen, Ruyong Yao, Zhongqiu Xu, Can Xu, Fujie He, Haitao Pei, Cui Hao   +8 more
doaj   +2 more sources

Synthesis of Nucleoside Derivatives by Biomimetic Ester Migration. [PDF]

Chembiochem
In tRNA aminoacylated nucleosides represent the central transfer unit of amino acids. An occurring 2′‐3′‐transaminoacylation is biomimetically exploited to successfully synthesize nucleosidic acid esters. This approach can be further expanded on sulfonic acid esters, which has the potential of a broad range of stereo‐ and regio‐controlled modifications
Kurrle NJ, Seifert CJB, Hampel N, Rauch T, Thoma M, Parziale LV, Ebeling MSR, Berthold D, Trapp O.   +8 more
europepmc   +2 more sources

Effectiveness of Amenamevir Vs. Valacyclovir in Preventing Herpes Zoster-Related Hospitalization and Complications: A Target Trial Emulation Using a Large Japanese Claims Database. [PDF]

J Dermatol
ABSTRACT Amenamevir is a novel anti‐herpes zoster drug that is increasingly used in Japan because of its once‐daily administration and lack of renal dose adjustment requirements. However, evidence of its clinical effectiveness is limited. This study aimed to estimate the clinical effectiveness of amenamevir vs. valacyclovir in preventing zoster‐related
Kano Y, Kimura Y, Yasunaga H.
europepmc   +2 more sources

Antiviral therapy for herpes simplex virus encephalitis: Systematic review and meta-analysis of randomized control trials

Journal of Applied Sciences and Clinical Practice, 2021
Background: Herpes simplex virus (HSV) infection of the brain is treated with antiviral drugs such as acyclovir. A summary of randomized control trials (RCTs) of antiviral drugs against HSV encephalitis has not been put forward yet. We aimed to determine
Sridhar Amalakanti, Sri Harsha Boppana, Nagarjuna Sivaraj, Kesava Venkata Raman Arepalli, Tarun Kumar Suvvari   +4 more
doaj   +2 more sources