Results 91 to 100 of about 489,349 (309)

Bacteroides thetaiotaomicron ameliorates mouse hepatic steatosis through regulating gut microbial composition, gut-liver folate and unsaturated fatty acids metabolism

Gut Microbes
Gut microbiota plays an essential role in the progression of nonalcoholic fatty liver disease (NAFLD), making the gut-liver axis a potential therapeutic strategy.
Hu Li, Xue-Kai Wang, Mei Tang, Lei Lei, Jian-Rui Li, Han Sun, Jing Jiang, Biao Dong, Hong-Ying Li, Jian-Dong Jiang, Zong-Gen Peng   +10 more
doaj   +1 more source

Ultrathin Hydrogel Membranes Inspired by Soap Films Enable Physiologically Relevant Breathing Lung Models

Advanced Materials, EarlyView.
A soap‐film inspired strategy enables the fabrication of ultrathin yet robust GelMA‐PAAm membranes for breathing lung culture. The hydrogel membrane supports long‐term cyclic deformation under air‐liquid interface conditions, enabling physiologically relevant breathing motions of engineered lung tissue culture. ABSTRACT Breathing continuously stretches
Yunji Lee, Gwang Myeong Kim, Wookyeom Kim, Fenny Soetanto, Gyungin Ryu, Taehun Chung, Youn Soo Kim, Junmin Lee, Hwa‐Rim Lee, Sungjune Jung   +9 more
wiley   +1 more source

Extrusion Bioprinting for Wound Healing: Innovations in Functionalized Bioinks and Bioprinting Technology

Advanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting (EBB) has emerged as a versatile biofabrication platform capable of precisely depositing bioinks composed of biomaterials, cells, and bioactive agents to generate patient‐specific, biomimetic skin constructs. This paper presents a state‐of‐the‐art and forward‐looking overview of EBB for wound healing, encompassing printing ...
Hien‐Phuong Le, Anh Tuan Trong Tran, Ammara Waheed, Tran Thanh Tung, Dusan Losic   +4 more
wiley   +1 more source

Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity [PDF]

Host-directed antivirals (HDAs) represent an attractive treatment option and a strategy for pandemic preparedness, especially due to their potential broad-spectrum antiviral activity and high barrier to resistance development.
Sparrer, Konstantin M. J., Hahn, Friedrich, Pfaender, Stephanie, Ensser, Armin, Gege, Christian, Dobner, Thomas, Cynis, Holger, Reuter, Sebastian, Vitt, Daniel, Groß, Rüdiger, Kohlhof, Hella, Ip, Wing-Hang, Hietel, Benjamin, Hunszinger, Victoria, Issmail, Leila, Wagner, Sabrina, Cordsmeier, Arne, Kögler, Melanie, Uhlig, Nadja, Münch, Jan, Irrgang, Pascal, Tenbusch, Matthias, Herrmann, Alexandra, Wangen, Christina, Grunwald, Thomas, Weil, Tatjana, Eberlein, Valentina, Heinen, Natalie, Klopfleisch, Robert   +28 more
core   +1 more source

Metabolism and function of hepatitis B virus cccDNA: Implications for the development of cccDNA-targeting antiviral therapeutics. [PDF]

, 2015
Persistent hepatitis B virus (HBV) infection relies on the stable maintenance and proper functioning of a nuclear episomal form of the viral genome called covalently closed circular (ccc) DNA.
Guo, Ju-Tao, Guo, Haitao
core   +1 more source

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

Antiviral Resistance in A(H7N9) viruses [PDF]

, 2014
Human infections with H7N9 avian influenza virus have raised concerns for an emerging pandemic influenza. Clinically, antiviral treatment with neuraminidase (NA) inhibitors reduced viral load in the throat swabs and improved clinical outcome in many ...
Guan, Y, Yen, H, Hu, Y, Webster, RG, Peiris, JSM, McKimm-Breschkin, JL   +5 more
core  

Influence of twenty potentially antiviral substances on in vitro multiplication of hepatitis A virus [PDF]

, 1986
A multiwell tissue culture system was developed to study the influence of various substances on hepatitis A virus (HAV) propagation. A panel of 20 substances of different structure types, each with known effect against at least some viruses, was studied ...
Nordenfelt, Erik, Öberg, Bo, Hansson, Bengt-Göran, Hansson, Bengt-Göran,, Widell, Anders, Lund University., Widell, Anders,   +6 more
core   +1 more source

A robust cell-based infection model for Rhinovirus C research and antiviral drug discovery

npj Viruses
Rhinoviruses (RV) comprise three species, RV-A, RV-B, and RV-C, with approximately 170 types. RV-C is associated with severe respiratory illness, particularly in children and individuals with asthma or chronic obstructive pulmonary disease, underscoring ...
Heyrhyoung Lyoo, Yeranddy A. Alpizar, Céline Sablon, Toon Röpke, Jasmine Paulissen, Madina Rasulova, Nathalie Thys, Chang-Soo Yun, Nam-Chul Cho, Kai Dallmeier, Pieter Leyssen, Soo-Bong Han, Johan Neyts, Hendrik Jan Thibaut   +13 more
doaj   +1 more source

Impact of mutations affecting 4′-fluorouridine susceptibility on fitness and treatment outcomes for Venezuelan equine encephalitis virus

Journal of Virology
Venezuelan equine encephalitis virus (VEEV) is a prototypical encephalitic alphavirus. Members of the Alphavirus genus are found across the globe, transmitted by arthropod vectors, and cause significant disease burdens in humans and animals.
Jenny Wong, Tahirah Moore, Devin Lewis, Carolin M. Lieber, Dariia Vyshenska, Elizabeth B. Sobolik, Sarah Zimmermann, George R. Painter, Richard K. Plemper, Alexander L. Greninger, Robert M. Cox   +10 more
doaj   +1 more source