Results 111 to 120 of about 662,292 (254)

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Senescent Factors Suppress Innate Antiviral Immunity in Aged Mice via Two Distinct Mechanisms. [PDF]

Aging Cell
Zhang X, Zhang Q, Wang L, Li S, Shu HB.
europepmc   +1 more source

Ribozyme für die RNA‐katalysierte Methylierung und Markierung von RNA

Angewandte Chemie, EarlyView.
Ribozyme sind vielseitige Werkzeuge für die präzise Modifikation von RNA. Das Reaktionsspektrum in‐vitro‐selektierter Ribozyme reicht vom Einbau funktioneller Gruppen und Fluorophoren bis zu natürlichen RNA‐Methylierungen. Dieser Übersichtsartikel präsentiert Cofaktor‐abhängige Ribozyme für die positionsgenaue Markierung und Modifikation von RNA ...
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

COVID-19 Antiviral Treatment: Examining Knowledge, Access, Trust in Sources of Information and Willingness to Use Among Essential Workers: A Cross-Sectional Survey of Cohort Participants. [PDF]

Health Sci Rep
Sanders J, James-Gist J, Shah MM, Graff N, Almendares O, Israel T, Zhu Y, Blette B, Hamid S, King H, Keipp Talbot H, Grijalva CG, Briggs-Hagen M.   +12 more
europepmc   +1 more source

Experimenteller Nachweis der metallbezogenen Funktion eines Cyanobactins

Angewandte Chemie, EarlyView.
Patellamide (Cyanobactine) werden von einer cyanobakteriellen Spezies in grosser Menge hergestellt. Diese zyklischen Peptide wurden in der Vergangenheit fast ausschliesslich auf ihre cytotoxischen Eigenschaften untersucht. Wir diskutieren neue experimentelle Daten, die auf eine Metallionen‐abhängige biologische Funktion der Patellamide schliessen ...
Philipp Baur, Timothy A. Hill, Kai‐Chen Wu, Junxian Lim, Brett M. Paterson, Gunasekaran Velmurugan, Bernard M. Degnan, David P. Fairlie, Peter Comba   +8 more
wiley   +1 more source

Intravitreal foscarnet is an effective adjunct after systemic therapy failure in pediatric antiviral-resistant cytomegalovirus retinitis. [PDF]

J Int Med Res
Amiri I, Shah P, Soleimani M, Zhang AY.
europepmc   +1 more source

Lycorine Derivative Inhibits SARS-CoV-2 Replication by Reducing -1 Programmed Ribosomal Frameshifting via Targeting ZAP. [PDF]

MedComm (2020)
Du T, Liu R, Zhang X, Shen L, Tang C, Wang J, Cheng Y, Yu W, Yin B, Lu S, Pan X, Peng X.   +11 more
europepmc   +1 more source

Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling

Angewandte Chemie International Edition, EarlyView.
Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

Antiviral activity and chemical characterization of Egyptian Ziziphus spina-christi against human respiratory viruses. [PDF]

Sci Rep
Elkhrsawy A, Kutkat O, Moatasim Y, Refaey MS, Al-Karmalawy AA, Elabd E, Keshta A, Shaltout K, El-Shesheny R.   +8 more
europepmc   +1 more source

Experimental Evidence for a Metal‐Related Function of a Cyanobactin

Angewandte Chemie International Edition, EarlyView.
Cyanobactins such as patellamides are produced by cyanobacteria profusely and have been studied extensively, but almost exclusively for their cytotoxic properties. Discussed is unprecedented experimental evidence for a metal‐related biological function – likely CO2 transport from the ascidian to the cyanobacterial symbiont.
Philipp Baur, Timothy A. Hill, Kai‐Chen Wu, Junxian Lim, Brett M. Paterson, Gunasekaran Velmurugan, Bernard M. Degnan, David P. Fairlie, Peter Comba   +8 more
wiley   +1 more source