Results 131 to 140 of about 489,349 (309)

A novel integrative machine learning-based prognostic model reveals lactylation regulation in hepatocellular carcinoma progression

Cancer Cell International
Background Hepatocellular carcinoma (HCC) is one of the most common malignant liver tumor with poor clinical outcomes. Accumulated evidence has demonstrated lactylation plays a vital role in the metabolic reprogramming.
Yihang Song, Dongdong Song, Xianbin Li, Danyang Li, Liwen Liu, Xuemeng Zhao, Yun Wang, Zishuo Wang, Zujiang Yu, Ranran Sun   +9 more
doaj   +1 more source

Identification and characterization of novel chikungunya virus polymerase inhibitors

Journal of Virology
Chikungunya virus (CHIKV) and other alphaviruses in the Togaviridae family are positive-sense RNA viruses and major human pathogens, causing millions of infections worldwide.
Peiqi Yin, Ryan Boyce, Sainan Wang, Michael Sirrine, Alexander Leach, Dillon Chu, Dariia Vyshenska, Zafer Sahin, Jenny Wong, Tahirah Moore, Devin Shane M. Lewis, Stephen C. Pelly, Dennis Liotta, Andres Merits, Alexander L. Greninger, Richard K. Plemper, Margaret Kielian, Robert M. Cox   +17 more
doaj   +1 more source

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

Advanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu, Da‐Wen Sun, QingYi Wei, Yibing Zhang, Jidong Tang, Hongbin Pu   +5 more
wiley   +1 more source

ProSiteHunter: A Unified Framework for Sequence‐Based Prediction of Protein‐Nucleic Acid and Protein‐Protein Binding Sites

Advanced Science, EarlyView.
This study proposed a unified sequence‐based framework for protein binding site prediction, which adopted a tri‐track semantic multi‐source feature fusion strategy to effectively capture diverse macromolecular interaction sites and further improved the accuracy of antibody‐antigen interaction prediction.
Dongliang Hou, Qihang Zhen, Zexin Lv, Xinyue Cui, Suhui Wang, Minghua Hou, Zhan Zhou, Xiaogen Zhou, Guijun Zhang   +8 more
wiley   +1 more source

Antiviral synergy between Zika virus protease and polymerase inhibitors [PDF]

, 2018
Zika virus (ZIKV) infection may be associated with congenital malformations in infected fetuses and severe complications in infected adults. There are limited treatment options that are readily available.
Chan, JFW, Chan, CS, Poon, KM, Yuen, KY, Yip, CY, Yuan, S, Chik, KKH   +6 more
core  

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Avaliação da atividade anti-rábica in vitro de compostos fenólicos sintéticos [PDF]

, 2005
Dissertação (mestrado) - Universidade Federal de Santa Catarina. Programa de Pós-Graduação em Biotecnologia.A raiva humana é uma doença de etiologia viral com grande impacto na saúde pública, principalmente por seu curso fatal, na grande maioria dos ...
Chávez, Juliana Helena
core  

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Summary of CDC recommendations for influenza antiviral medications [PDF]

January 15, 2013, 16:00 ETCDCHAN-00339CDC continues to recommend antiviral medications for treatment of seasonal influenza and annual vaccination as the best tools for prevention.Evidence from past influenza seasons and the 2009 H1N1 pandemic has shown ...

core  

Emergence and Fixing of Antiviral Resistance in Influenza A Via Recombination and Hitch Hiking [PDF]

, 2009
The dramatic rise of oseltamivir resistance in the H1N1 serotype in the 2007/2008 season and the fixing of H274Y in the 2008/2009 season has raised concerns regarding individuals at risk for seasonal influenza, as well as development of similar ...
Henry L. Niman
core   +1 more source