Results 31 to 40 of about 526,776 (304)

Vitamin D increases the antiviral activity of bronchial epithelial cells in vitro [PDF]

, 2016
BACKGROUND: By modulating the antiviral immune response via vitamin D receptor, the active form of vitamin D (1,25-dihydroxyvitamin D, calcitriol) could play a central role in protection against respiratory virus infections.
Laza-Stanca, V, Telcian, AG, Mallia, P, Zdrenghea, MT, Edwards, MR, Stanciu, LA, Johnston, SL   +6 more
core   +1 more source

Gene Knockout Shows That PML (TRIM19) Does Not Restrict the Early Stages of HIV-1 Infection in Human Cell Lines

mSphere, 2017
The PML (promyelocytic leukemia) protein is a member of the TRIM family, a large group of proteins that show high diversity in functions but possess a common tripartite motif giving the family its name.
Nasser Masroori, Pearl Cherry, Natacha Merindol, Jia-xin Li, Caroline Dufour, Lina Poulain, Mélodie B. Plourde, Lionel Berthoux   +7 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Impact of cellular proteases on the function of antiviral antibodies

Journal of Virology
Viruses evade antibodies through many mechanisms. While mutation remains the predominant pathway, host proteases can be hijacked upon viral infections and decrease antibody-mediated clearance.
Mateo Krzypow, Olivier Schwartz, Timothée Bruel, Andréa Cottignies-Calamarte   +3 more
doaj   +1 more source

Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies

Virology Journal, 2019
Background Vaccination and the use of neuraminidase inhibitors (NAIs) are currently the front lines of defense against seasonal influenza. The activity of influenza vaccines and antivirals drugs such as the NAIs can be affected by mutations in the ...
Natalia A. Ilyushina, Takashi E. Komatsu, William L. Ince, Eric F. Donaldson, Nicolette Lee, Julian J. O’Rear, Raymond P. Donnelly   +6 more
doaj   +1 more source

Advances with RNAi-Based Therapy for Hepatitis B Virus Infection

Viruses, 2020
Infection with hepatitis B virus (HBV) remains a global health challenge. Approximately 292 million people worldwide are chronically infected with HBV and the annual mortality from the infection is approaching 900,000.
Fiona van den Berg, Shonisani Wendy Limani, Njabulo Mnyandu, Mohube Betty Maepa, Abdullah Ely, Patrick Arbuthnot   +5 more
doaj   +1 more source

Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses

Cells, 2021
Host cell-intrinsic antiviral responses are largely mediated by pattern-recognition receptor (PRR) signaling and the interferon (IFN) system. The IFN regulatory factor (IRF) family of transcription factors takes up a central role in transcriptional ...
Sandra Wüst, Paulina Schad, Sandy Burkart, Marco Binder   +3 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Triagem da potencial atividade antiviral de peptídeos antimicrobianos e da hemolinfa de ostras [PDF]

, 2005
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Biotecnologia.Os produtos naturais constituem uma fonte inesgotável de compostos com atividades farmacológicas promissoras, incluindo ação antiviral.
Gomes, Márcia Cristina Carriel
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source