Results 21 to 30 of about 383,701 (263)

Efficient and unbiased metagenomic recovery of RNA virus genomes from human plasma samples

Scientific Reports, 2017
RNA viruses cause significant human pathology and are responsible for the majority of emerging zoonoses. Mainstream diagnostic assays are challenged by their intrinsic diversity, leading to false negatives and incomplete characterisation.
Carmen F. Manso, David F. Bibby, Jean L. Mbisa   +2 more
doaj   +1 more source

Isolation and Characterization of Jumbo Coliphage vB_EcoM_Lh1B as a Promising Therapeutic Agent against Chicken Colibacillosis

Microorganisms, 2023
Colibacillosis in chickens can cause the death of young stock, decrease weight gain and lead to significant economic losses. Currently, antibiotic therapy is the main method of treatment of infected animals, but unchecked use of antibiotics has led to ...
Pavel Alexyuk, Andrey Bogoyavlenskiy, Madina Alexyuk, Kuralay Akanova, Yergali Moldakhanov, Vladimir Berezin   +5 more
doaj   +1 more source

Optimization of a Sustainable Keratin Extraction Process from Waste Slaughterhouse Feathers: A Practice and Business Model Innovation [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2023
The extraction of keratin from natural feathers has been studied for its use in various cosmetics and drug delivery applications. There are various reducing agents to dissolve the hard keratin such as sodium dodecyl sulfate and 2-mercaptoethanol, in the ...
Bechr Hamrita, Sabrine Hamed, Rania Elayeb, Ferdaws Hafi, Mondher Njehi, Hatem Majdoum, Manel Mhadheb, Sami Achour   +7 more
doaj   +1 more source

ssAAVs containing cassettes encoding SaCas9 and guides targeting hepatitis B virus inactivate replication of the virus in cultured cells

Scientific Reports, 2017
Management of infection with hepatitis B virus (HBV) remains a global health problem. Persistence of stable covalently closed circular DNA (cccDNA) during HBV replication is responsible for modest curative efficacy of currently licensed drugs. Novel gene
Tristan Scott, Buhle Moyo, Samantha Nicholson, Mohube Betty Maepa, Koichi Watashi, Abdullah Ely, Marc S. Weinberg, Patrick Arbuthnot   +7 more
doaj   +1 more source

Cooperative effects of RIG-I-like receptor signaling and IRF1 on DNA damage-induced cell death

Cell Death and Disease, 2022
Properly responding to DNA damage is vital for eukaryotic cells, including the induction of DNA repair, growth arrest and, as a last resort to prevent neoplastic transformation, cell death.
David Y. Zander, Sandy S. Burkart, Sandra Wüst, Vladimir G. Magalhães, Marco Binder   +4 more
doaj   +1 more source

Advances with RNAi-Based Therapy for Hepatitis B Virus Infection

Viruses, 2020
Infection with hepatitis B virus (HBV) remains a global health challenge. Approximately 292 million people worldwide are chronically infected with HBV and the annual mortality from the infection is approaching 900,000.
Fiona van den Berg, Shonisani Wendy Limani, Njabulo Mnyandu, Mohube Betty Maepa, Abdullah Ely, Patrick Arbuthnot   +5 more
doaj   +1 more source

Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies

Virology Journal, 2019
Background Vaccination and the use of neuraminidase inhibitors (NAIs) are currently the front lines of defense against seasonal influenza. The activity of influenza vaccines and antivirals drugs such as the NAIs can be affected by mutations in the ...
Natalia A. Ilyushina, Takashi E. Komatsu, William L. Ince, Eric F. Donaldson, Nicolette Lee, Julian J. O’Rear, Raymond P. Donnelly   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses

Cells, 2021
Host cell-intrinsic antiviral responses are largely mediated by pattern-recognition receptor (PRR) signaling and the interferon (IFN) system. The IFN regulatory factor (IRF) family of transcription factors takes up a central role in transcriptional ...
Sandra Wüst, Paulina Schad, Sandy Burkart, Marco Binder   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source