Results 11 to 20 of about 489,349 (309)
Advanced virtual screening enables the discovery of a host-targeting and broad-spectrum antiviral agent [PDF]
, 2023 We employed an advanced virtual screening (AVS) approach to identify potential inhibitors of human dihydroorotate dehydrogenase (DHODH), a validated target for development of broad-spectrum antivirals.
Shavina, Anastasiya +27 more
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Antiviral drugs and antiviral drug resistance [PDF]
Current Opinion in Virology, 2011 Antiviral drugs and antiviral drug resistance can be matters of life and death for patients suffering from viral infections. They also can be valuable tools for understanding virus biology and biochemistry. Triumphs of antiviral therapy include acyclovir to treat genital herpes [1–4], triple combination chemotherapy for AIDS [5,6], and, quite recently,
Donald M, Coen, Richard J, Whitley
openaire +2 more sources
, 2014 Recombinant human interferon-omega (rhIFN-omega) exhibits a potent antiviral activity. Because of poor pharmacokinetics (PK) of rhIEN-omega, frequent dosing of rhIFN-omega is necessitated to achieve the sustained antiviral efficacy.
Fang, Ting +9 more
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Antivirals and antiviral strategies [PDF]
Nature Reviews Microbiology, 2004 In recent years, the demand for new antiviral strategies has increased markedly. There are many contributing factors to this increased demand, including the ever-increasing prevalence of chronic viral infections such as HIV and hepatitis B and C, and the emergence of new viruses such as the SARS coronavirus.
openaire +2 more sources
Antiviral activities of niclosamide and nitazoxanide against chikungunya virus entry and transmission [PDF]
, 2017 Chikungunya disease results from an infection with the arbovirus, chikungunya virus (CHIKV). Symptoms of CHIKV include fever and persistent, severe arthritis.
林亮音 +1 more
core +1 more source
Population-Wide Emergence of Antiviral Resistance during Pandemic Influenza [PDF]
, 2008 Background: The emergence of neuraminidase inhibitor resistance has raised concerns about the prudent use of antiviral drugs in response to the next influenza pandemic.
Wu, Jianhong +13 more
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Epidemiological consequences of household-based antiviral prophylaxis for pandemic influenza [PDF]
, 2013 Antiviral treatment offers a fast acting alternative to vaccination; as such it is viewed as a first-line of defence against pandemic influenza in protecting families and households once infection has been detected.
M. J. Keeling +15 more
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Antiviral potential of cathelicidins [PDF]
, 2014 The global burden of morbidity and mortality arising from viral infections is high; however, the development of effective therapeutics has been slow.
Davidson, Donald J +4 more
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Scientific Reports, 2017 Management of infection with hepatitis B virus (HBV) remains a global health problem. Persistence of stable covalently closed circular DNA (cccDNA) during HBV replication is responsible for modest curative efficacy of currently licensed drugs. Novel gene
Tristan Scott +7 more
doaj +1 more source