Results 41 to 50 of about 3,421,754 (284)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Frontiers in Anti-infective Agents

, 2022
Ocular drug targeting is one of the most interesting and challenging research topics due to the presence of natural barriers of the eye that attract pharmaceutical technologists.
Erginer, Yıldız, Güngör, Sevgi, Durgun, Meltem Ezgi, Durgun Kılıç, Meltem Ezgi   +3 more
core  

Infections, Anti-infective Agents, and Risk of Deliberate Self-harm and Suicide in a Young Cohort:A Nationwide Study [PDF]

, 2019
BACKGROUND: Evidence links infections to mental disorders and suicidal behavior. However, knowledge is sparse regarding less severe infections, anti-infective treatment, and deliberate self-harm.
Nordentoft, Merete, Erlangsen, Annette, Gjervig Hansen, Helene, Benros, Michael E, Petersen, Liselotte, Köhler-Forsberg, Ole, Postolache, Teodor T   +6 more
core   +1 more source

Thiourethane-functionalized fillers: biological properties and degradation resistance [PDF]

Brazilian Oral Research
This study determined the effect of thiourethane-functionalized fillers (TU) on the antimicrobial properties, cytotoxicity, degree of conversion (DC), water sorption (Wsp) and solubility (Wsl) of experimental composites. TU-modified fillers were added at
Larissa Maria CAVALCANTE, Amanda Barreto RAMOS, Daniela Costa SILVA, Gutemberg Gomes ALVES, Karinne Bueno ANTUNES, Carmem Silvia PFEIFER, Luis Felipe Jochims SCHNEIDER   +6 more
doaj   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Topical applications of ozone and ozonated oils as anti-infective agents: an insight into the patent claims

, 2009
Orthodox medicine has been very active in the field of topical anti-infective agents and current chemotherapy has procured valid antibiotics, antivirals, vaccines, antibodies, and antiparasitic drugs to be parenterally and/or topically used.
Bocci V., Travagli V., Zanardi I.
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Additional file 1 of Pharmacovigilance study of anti-infective-related acute kidney injury using the Japanese adverse drug event report database

, 2021
Additional file 1: Figure S1. Histograms and the corresponding Weibull shape parameters of AKIs associated with 14 anti-infective categories for which the number of cases was more than 100 and the lower limit of the 95% CI exceeded 1 in Table 3.
Riko Satake (11182983), Misaki Inoue (11182986), Yuri Nishibata (4710309), Mizuki Tanaka (4636117), Ryogo Umetsu (4710310), Kiyoka Matsumoto (7474502), Satoshi Nakao (2258755), Kazuyo Shimada (5195372), Jun Liao (1402627), Yu Yoshida (1671214), Shiori Hasegawa (2802643), Mitsuhiro Nakamura (11357160), Ririka Mukai (6447422)   +12 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source