Results 41 to 50 of about 120,532 (302)

From screen to target: insights and approaches for the development of anti-virulence compounds [PDF]

, 2014
A detailed understanding of host-pathogen interactions provides exciting opportunities to interfere with the infection process. Anti-virulence compounds aim to modulate or pacify pathogenesis by reducing expression of critical virulence determinants.
Beckham, Katherine S.H., Roe, Andrew J.
core   +7 more sources

Public contributions to the development of antibiotics: two successful and two failed investments

Journal of Pharmaceutical Policy and Practice
Background The aim is to showcase a detailed analysis of the contribution of public funding to two successful (gepotidacin and zoliflodacin) and two failed (epetraborole and ridnilazole) public sector investments in antibiotic development, using a ...
Louise Schmidt, Ozren Sehic, Ursula Theuretzbacher, Claudia Wild   +3 more
doaj   +1 more source

Influence of addition of [2-(methacryloyloxy)ethyl]trimethylammonium chloride to an experimental adhesive

Brazilian Oral Research, 2017
The aim of this study was to develop an experimental adhesive with addition of [2-(methacryloyloxy)ethyl]trimethylammonium chloride (METAC) and to evaluate its mechanical and biological properties and its in vitro antibacterial activity.
Fabrício Mezzomo COLLARES, Vicente Castelo Branco LEITUNE, Patrícia FRANKEN, Clarissa Fatturi PAROLLO, Fabrício Aulo OGLIARI, Susana Maria Werner SAMUEL   +5 more
doaj   +1 more source

Exploring the immunology of parasitism--from surface antigens to the hygiene hypothesis [PDF]

, 2009
Helminth immunology is a field which has changed beyond recognition in the past 30 years, transformed not only by new technologies from cDNA cloning to flow cytometry, but also conceptually as our definition of host immune pathways has matured.
Maizels, R M
core   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

‘Piloting a framework for analysing the public contributions to R&D: new antibiotics in focus’

Journal of Pharmaceutical Policy and Practice
Background Within the context of increasing transparency around public contributions, a framework for reporting and analysing public contributions to research and development (R&D) was previously developed and is piloted here using the example of ...
Louise Schmidt, Ozren Sehic, Ursula Theuretzbacher, Daniel Fabian, Claudia Wild   +4 more
doaj   +1 more source

Prevention of enteroxigenic Escherichia coli infections in pigs by dairy-based nutrition [PDF]

, 2015
Postweaning diarrhea (PWD) is a significant enteric disease causing considerable economic losses for the pig industry. Among several aetiological risk factors, enterotoxigenic Escherichia coli (ETEC) is considered to be a major cause.
Jensen, BB, Jensen, KH, Lauridsen, C, Sugiharto, Sugiharto   +3 more
core  

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

A preliminary report on the contact-independent antagonism of Pseudogymnoascus destructans by Rhodococcus rhodochrous strain DAP96253. [PDF]

, 2014
BackgroundThe recently-identified causative agent of White-Nose Syndrome (WNS), Pseudogymnoascus destructans, has been responsible for the mortality of an estimated 5.5 million North American bats since its emergence in 2006.
Barlament, Courtney K, Cornelison, Christopher T, Crow, Sidney A, Gabriel, Kyle T, Keel, M Kevin, Pierce, George E, Tucker, Trudy A   +6 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source