Results 41 to 50 of about 162,736 (290)

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

‘Piloting a framework for analysing the public contributions to R&D: new antibiotics in focus’

Journal of Pharmaceutical Policy and Practice
Background Within the context of increasing transparency around public contributions, a framework for reporting and analysing public contributions to research and development (R&D) was previously developed and is piloted here using the example of ...
Louise Schmidt, Ozren Sehic, Ursula Theuretzbacher, Daniel Fabian, Claudia Wild   +4 more
doaj   +1 more source

Teixobactin: a novel anti-infective agent [PDF]

Expert Review of Anti-infective Therapy, 2018
In 2015, a screen of bacterial strains produced a novel antibiotic with broad antimicrobial activity known as teixobactin [1].
openaire   +2 more sources

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Influence of addition of [2-(methacryloyloxy)ethyl]trimethylammonium chloride to an experimental adhesive

Brazilian Oral Research, 2017
The aim of this study was to develop an experimental adhesive with addition of [2-(methacryloyloxy)ethyl]trimethylammonium chloride (METAC) and to evaluate its mechanical and biological properties and its in vitro antibacterial activity.
Fabrício Mezzomo COLLARES, Vicente Castelo Branco LEITUNE, Patrícia FRANKEN, Clarissa Fatturi PAROLLO, Fabrício Aulo OGLIARI, Susana Maria Werner SAMUEL   +5 more
doaj   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Reducing self--medication with anti-infective agents in Lagos, nigeria: a community-based intervention study

, 2019
Background: Self-medication with anti-infective agents is a global public health concern particularly in the developing countries. In this study, the rate and pattern of self-medication with anti-infective agents and effectiveness of an educational ...
Oreagba, I.A., Lawal, M.S., Oshikoya, K.A., Omotosho, O.A., Busari, A.A.   +4 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Prospects for novel inhibitors of peptidoglycan transglycosylase [PDF]

, 2014
The lack of novel antimicrobial drugs under development coupled with the increasing occurrence of resistance to existing drugs by community and hospital acquired infections is of grave concern.
Galley, Nicola F., O'Reilly, Amy M., O’Reilly, Amy M., Roper, David I.   +3 more
core   +1 more source

Circumventing resistance to anti-infective agents [PDF]

Expert Opinion on Pharmacotherapy, 2015
The search for anti-infective agents to treat infections caused by a variety of pathogenic organisms has a long history.
openaire   +2 more sources