Results 51 to 60 of about 3,421,754 (284)
, 2019 Background: Self-medication with anti-infective agents is a global public health concern particularly in the developing countries. In this study, the rate and pattern of self-medication with anti-infective agents and effectiveness of an educational ...
Oreagba, I.A. +4 more
core +1 more source
, 2021 Ever since the development of the first antibiotic compound with anticancer potential, researchers focused on isolation and characterization of prospective microbial natural products with potential anti-infective and anticancer activities.
Chakraborty, Kajal, Vinaya, K K
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Anti-infectives for the treatment of infective endocarditis.
, 2016 Anti-infectives for the treatment of infective endocarditis.
Haibin Dai (464649) +2 more
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Limited-Sampling Strategies for Anti-Infective Agents: Systematic Review [PDF]
, 2009 Background: Area under the concentration–time curve (AUC) is a pharmacokinetic parameter that represents overall exposure to a drug. For selected anti-infective agents, pharmacokinetic–pharmacodynamic parameters, such as AUC/MIC (where MIC is the minimal
Sprague, Denise A, Ensom, Mary H H
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Therapeutic drug monitoring of anti-infective agents in critically ill patients
, 2016 Initial adequate anti-infective therapy is associated with significantly improved clinical outcomes for patients with severe infections. However, in critically ill patients, several pathophysiological and/or iatrogenic factors may affect the ...
Jager, Nynke G L +9 more
core +1 more source
Anti Infective Agents in Medicinal Chemistry
, 2010 Anti Infective Agents in Medicinal Chemistry Basic and applied science in the field of antimicrobial ...
MANFREDI, ROBERTO
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source