Results 71 to 80 of about 162,736 (290)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Comparative Evaluation of Antimicrobial Activity of 0.2% Lemongrass Oil and 0.2% Chlorhexidine as a Preprocedural Mouth Rinse: A Randomised Controlled, Parallel Design, Split-mouth Clinical Trial [PDF]

Journal of Clinical and Diagnostic Research
Introduction: The aerosols produced by an ultrasonic scaler contain bacteria that may enter the respiratory systems of both dental surgeons and patients.
Gautami S Penmetsa, Bhavya Manchala, Manisha Beldhi, Keerthi Vinnakota, Karumuri Taraka Sunil Kumar, Srikurmam Anil babu   +5 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

In vitro effectiveness of Brazilian brown propolis against Enterococcus faecalis

Brazilian Oral Research, 2015
The aim of this study was to evaluate the in vitro antimicrobial activity of Brazilian brown propolis as an intracanal medication against Enterococcus faecalis.
Hévelin Couto PIMENTA, Ivana Maria Povoa VIOLANTE, Carlo Ralph de MUSIS, Álvaro Henrique BORGES, Andreza Maria Fábio ARANHA   +4 more
doaj   +1 more source

Arylsulphones: A Promising Class on Non-Nucleoside Antiviral Agents

, 2005
The design and development of antiviral agents are an urgent need. The continuing problem associated with the emergence of drug resistant strains stimulates for new compounds for the treatment of both chronic diseases and acute infections.
GARUTI, LAURA, POGGI, GABRIELLA, ROBERTI, MARINELLA, PIZZIRANI, DANIELA   +3 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Anti-infective effects o Lactobacilli in the gastrointestinal tract

, 2003
Antibiotics constitute the dominant treatment of gastrointestinal infections. However, several serious side-effects are associated with extensive use of antibiotics, including spread of bacterial resistance and allergic reactions as well as potential ...
Thorlacius, Henrik,, Lund University., Jeppsson, Bengt,   +2 more
core  

Secretory Profile of Selected Gut Bacteria of Cockroaches: A Potential Source of Anti-Infective Agents

, 2022
Pests, such as cockroaches, thrive in polluted conditions that are detrimental to Homo sapiens, suggesting that such species possess mechanisms to protect themselves against pathogens.
Ruqaiyyah Siddiqui, Akbar, Noor, Naveed Ahmed Khan, Mohamed Yehia Abouleish, Abouleish, Mohamed Yehia, Jibran Sualeh Muhammad, Siddiqui, Ruqaiyyah, Muhammad, Jibran Sualeh; id_orcid, Siddiqui, Ruqaiyyah; id_orcid, Khan, Naveed Ahmed, Muhammad, Jibran Sualeh, Noor Akbar, Khan, Naveed Ahmed *   +12 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source