Results 91 to 100 of about 163,167 (287)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Anti-mycobacterial activity of quinolones: triazoloquinolones a new class of potent anti mycobacterial agents [PDF]
, 2008 A number of novel quinolone derivatives have been recentlyreported to posses in vitro and in vivo anti mycobacterial and DNA gyrase inhibition activities.
Zanetti, S. +8 more
core +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Evaluation of the Antibacterial Activity of Annatto Dye on Some Pathogenic Bacteria
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2014 Background and Objectives:Today, disadvantages of antibiotics and synthetic preservatives have been identified, and researchers are seeking natural and safe alternatives.
Mahmoud Yolmeh +3 more
doaj
Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2023 Objective: To green synthesise gold nanoparticles using curcumin and to analyse its antioxidant, anti-inflammatory, and antimicrobial activity among oral pathogens.
Sreedevi Dharman +3 more
doaj
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Comparative Analysis of Patient Package Inserts of Local and Imported Anti-Infective Agents in Palestine [PDF]
, 2008 Background and Objective: The patient package insert is an important source of drug information. The aim of this study was to evaluate and compare the PPI of the anti-infective agents manufacturedin Palestine with the imported equivalents.
Sweileh WM +7 more
core +2 more sources
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Anti-infective ophthalmic preparations in general practice [PDF]
, 2012 CITATION: Smit, D. 2012. Anti-infective ophthalmic preparations in general practice. South African Family Practice, 54(4):302-307.The original publication is available at http://www.safpj.co.zaOcular infections may be bacterial, viral, fungal or ...
D Smit, D. Smit, Smit, Derrick
core +1 more source