Results 61 to 70 of about 120,532 (302)

The Role of Common Solvents against Pseudomonas aeruginosa-Induced Pathogenicity in a Murine Burn Site Infection Model

Microbiology Spectrum, 2021
Dimethyl sulfoxide (DMSO) and polyethylene glycols (PEGs) are frequently used as potent excipients in pharmaceutical formulations. However, these agents also have an interesting antimicrobial and anti-inflammatory profile that could interfere with the ...
Vijay K. Singh, Marianna Almpani, Laurence G. Rahme   +2 more
doaj   +1 more source

Teixobactin: a novel anti-infective agent [PDF]

Expert Review of Anti-infective Therapy, 2018
In 2015, a screen of bacterial strains produced a novel antibiotic with broad antimicrobial activity known as teixobactin [1].
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Drugs Targeting Sirtuin 2 Exhibit Broad-Spectrum Anti-Infective Activity

Pharmaceuticals
Direct-acting anti-infective drugs target pathogen-coded gene products and are a highly successful therapeutic paradigm. However, they generally target a single pathogen or family of pathogens, and the targeted organisms can readily evolve resistance ...
Thomas Shenk, John L. Kulp III, Lillian W. Chiang   +2 more
doaj   +1 more source

Revealing Indigenous Indonesian Traditional Medicine: Anti-infective Agents

Natural Product Communications, 2011
Indonesia is rich in medicinal plants which the population has used traditionally from generation to generation for curing diseases. Our interest in the treatment of infectious diseases has lead to the investigation of traditional Indonesian treatments ...
Ari S. Nugraha, Paul A. Keller
doaj   +1 more source

Identification of Prescribing Patterns in Hemodialysis Outpatients Taking Multiple Medications

Pharmacy, 2023
We investigated the relationship between multidrug administration and the characteristics, pathophysiology, and drug class in outpatients with hemodialysis.
Hiroyuki Nagano, Koji Tomori, Mano Koiwa, Shotaro Kobayashi, Masahiro Takahashi, Hideki Makabe, Hirokazu Okada, Akifumi Kushiyama   +7 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Circumventing resistance to anti-infective agents [PDF]

Expert Opinion on Pharmacotherapy, 2015
The search for anti-infective agents to treat infections caused by a variety of pathogenic organisms has a long history.
openaire   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Janus-faced role of anti-infective drugs: a revisit through the lens of vascular ageing [PDF]

Exploration of Drug Science
Background: Vascular aging is a major driver of cardiovascular, metabolic, and degenerative diseases, characterized by oxidative stress, mitochondrial dysfunction, endothelial senescence, and impaired proteostasis.
Ceaser Wankumbu Silumbwe, Julius Mulumba, Satheesh Kumar Dharmarajan, Anusha Chennuru, Lukundo Siame, Kebby Mazyamuna   +5 more
doaj   +1 more source