Results 21 to 30 of about 3,594,283 (182)

Emerging paradigms in anti-infective drug design. [PDF]

, 2014
The need for new drugs to treat microbial infections is pressing. The great progress made in the middle part of the twentieth Century was followed by a period of relative inactivity as the medical needs relating to infectious disease in the wealthier ...
Croft, Simon L, Barrett, Michael P., Barrett, Michael P, Croft, Simon L.   +3 more
core   +1 more source

Linking sustainable use policies to novel economic incentives to stimulate antibiotic research and development

Infectious Disease Reports, 2017
There is now global recognition that antibiotic resistance is an emerging public health threat. Policy initiatives are underway to provide concrete suggestions for overcoming important obstacles in the fight against antibiotic resistance, like the ...
Ursula Theuretzbacher, Christine Årdal, Stephan Harbarth   +2 more
doaj   +1 more source

Insights into early stage of antibiotic development in small- and medium-sized enterprises: a survey of targets, costs, and durations

Journal of Pharmaceutical Policy and Practice, 2018
Background Antibiotic innovation has dwindled to dangerously low levels in the past 30 years. Since resistance continues to evolve, this innovation deficit can have perilous consequences on patients.
Christine Årdal, Enrico Baraldi, Ursula Theuretzbacher, Kevin Outterson, Jens Plahte, Francesco Ciabuschi, John-Arne Røttingen   +6 more
doaj   +1 more source

Factors associated with PPSV23 coverage among older adults in Japan: a nationwide community-based survey

BMJ Open, 2019
Objectives The 23-valent pneumococcal polysaccharide vaccine (PPSV23) was included in Japan’s national immunisation programme for older adults in 2014.
Yoshitaka Murakami, Shinichi Kanazu, Tanaz Petigara, Mari Saito Oba, Yuji Nishiwaki, Akira Watanabe   +5 more
doaj   +1 more source

Phytomedicinal properties of Hygrophila schulli (Neeramulliya) [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Hygrophila schulli which is known as “Neermulli’’ in the vernacular is an herbaceous plant native to Sri Lanka. Ancient medicinal literature suggests the use of H.
Malshani Nissanka, Manjula Weerasekera, Ayomi Dilhari, Ranga Dissanayake, Sajeewa Rathnayake, Gayan Wijesinghe   +5 more
doaj   +1 more source

Evaluation of Antimicrobial Efficacy of Modified Novel Double Antimicrobial Preparations Against E.Faecalis and C. Albicans: An In-vitro Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: The aim of endodontic treatment is the reduction of microbial load inside the root canal, for which Calcium hydroxide {Ca(OH)2} is the most commonly used medicament, which is ineffective against resistant microbes such as E.faecalis and C ...
N Meena, G Vinay Kumar, Vinoo Subramaniam, Sibi Swamy, Vk Vijay   +4 more
doaj   +1 more source

Liposomes used in the delivery of various antimicrobials to biofilm-producing infections: a systematic review [PDF]

Nanomedicine Journal
Objective(s): Persistent clinical infections have driven extensive research to find effective solutions. Liposomes, known for their biocompatibility, versatility, targetability, and tunability, have emerged as a prominent drug delivery system.
Manouchehr Teymouri, Samaneh Mollazadeh, Fatemeh Oroojalian, Amir Amani, Roghaye Arezumand, Farzane Shakeri, Reza Besharati, Parastoo Zarghami Moghaddam   +7 more
doaj   +1 more source

Formulation and Evaluation of Antimicrobial, Anti-inflammatory, and Physicochemical Properties of Herbal Oral Gel Prepared from Jasminum grandiflorum Leaf Extract: An In-vitro Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Periodontitis is a chronic inflammatory disease that requires effective management, often involving adjunct therapies like chlorhexidine, but it comes with its own set of side-effects, creating a need for alternatives. Jasminum grandiflorum
G Supraja, M Sankari
doaj   +1 more source

Broken drug markets in infectious diseases: Opportunities outside the private sector? [PDF]

PLoS Neglected Tropical Diseases, 2019
A subset of anti-infective drugs are increasingly unavailable for patients in the United States due to pricing or withdrawal from the market. Timely market solutions are needed.
Jonathan D Alpern, Stephen J Dunlop, William M Stauffer   +2 more
doaj   +1 more source

Diagnostic Utility of Bronchoalveolar Lavage in Patients with Acute Leukemia under Broad-Spectrum Anti-Infective Treatment

, 2022
SIMPLE SUMMARY: Infections of bacterial, viral, or fungal origin pose a major threat to patients with acute leukemia. Empiric antibiotic and antifungal treatment is a commonly used approach in leukemia patients with febrile neutropenia.
Henes, Frank O., Carsten Bokemeyer, Hoffmann, Armin, Susanne Ghandili, Nick Benjamin Lindeman, Frank O. Henes, Modemann, Franziska, Armin Hoffmann, von Kroge, Philipp H., Holger Rohde, Rohde, Holger, Simon, Marcel, Marcel Simon, Franziska Modemann, Lindeman, Nick Benjamin, Walter Fiedler, Ghandili, Susanne, Bokemeyer, Carsten, Philipp H. von Kroge, Fiedler, Walter   +19 more
core   +1 more source