Results 31 to 40 of about 81,920,088 (158)

From o‐Phenylenediamine to Flavin Derivatives: A Potential Prebiotic Carbon Skeleton Expansion With Formaldehyde, Cyanide, and CO2

Advanced Synthesis &Catalysis, Volume 368, Issue 16, 18 August 2026.
A Strecker‐type reaction of aromatic ortho‐diamines with various aldehydes and cyanide assembles the bicyclic amidine core of flavin‐derived heterocycles under mild conditions. Subsequent oxidation, radical or photochemical cyanation, carboxylation with CO2, and CO2‐mediated cyclization build the three‐ring alloxazine scaffold. This sequence provides a
Christian Held, Rodrigo José da Silva Lima, Ji‐Woong Lee   +2 more
wiley   +1 more source

Palladium-Catalyzed Double C-H Arylation Reaction: Tandem Synthesis of Benzo[ a ]imidazo[5,1,2- cd ]indolizines from Imidazo[1,2- a ]pyridines and o -Dihaloarenes [PDF]

, 2015
A palladium-catalyzed direct arylation of 2-arylimidazo[1,2-a]pyridines with o-dihaloarenes via double C-H activation is described. The process comprises intermolecular C3-arylation of 2-arylimidazo[1,2-a]pyridines followed by an intramolecular C5 ...
Wang, Hanyang, Peng, Jinsong, Yao, Liping, Li, Bin, Chen, Chunxia, Huang, Zhangjie   +5 more
core   +1 more source

1,1,1,3,3,3-Hexafluoro-2-Propanol-Promoted Friedel–Crafts Reaction: Metal-Free Synthesis of C3-Difluoromethyl Carbinol-Containing Imidazo[1,2-a]pyridines at Room Temperature [PDF]

, 2023
A facile and efficient method has been developed for the synthesis of C3-difluoromethyl carbinol-containing imidazo[1,2-a]pyridines at room temperature via the HFIP-promoted Friedel–Crafts reaction of difluoroacetaldehyde ethyl hemiacetal and imidazo[1,2-
Kai Yang, Juanjuan Gao, Xiaohua Guo, Zhaowen Liu, Zhixi Chen, Longhui Wu   +5 more
core   +1 more source

From Molecules to Materials: The Role of Halogen Bonds in Electron Donor–Acceptor Complex Mediated Organic Synthesis

European Journal of Organic Chemistry, Volume 29, Issue 30, 12 August 2026.
This Concept highlights recent advances in organic synthesis based on electron donor–acceptor (EDA) complex photochemistry, with emphasis on halogen bonding. Halides play a dual role as key components of this noncovalent interaction, and as reactivity‐enabling leaving groups.
Marco Manni, Giacomo Filippini
wiley   +1 more source

3,5-Diarylimidazo[1,2-a]pyridines as Color-Tunable Fluorophores [PDF]

, 2017
A new protocol for the synthesis of color-tunable fluorescent 3,5-diarylimidazo[1,2-a]pyridines has been achieved via palladium-catalyzed C-H amination of pyridinium zwitterions.
Eun Jeong Yoo, Hong Ki Kim, Donguk Ko, Mu-Hyun Baik, Ju Young Lee, Jae Yul Shim   +5 more
core   +1 more source

A Solvent‐Free Synthesis of Imidazo[1,5‐a]pyridines Using CCl4 as an Oxidant

Journal of Heterocyclic Chemistry, Volume 63, Issue 8, Page 1288-1299, August 2026.
A solvent‐free synthesis of imidazo[1,5‐a]pyridines (Impys) using CCl4 as an oxidant reagent and DBU as the base is informed. An array of Impys derived from different benzylic, heteroaryl aldehydes and others was synthesized in moderate to good yields.
Alejandro Castillo‐Baltazar, Luis E. Mendoza‐Herrera, Alfredo Toscano, J. Armando Luján‐Montelongo, M. Carmen Ortega‐Alfaro, José G. López‐Cortés   +5 more
wiley   +1 more source

CuBr catalyzed aerobic oxidative coupling of 2-aminopyridines with cinnamaldehydes: direct access to 3-formyl-2-phenyl-imidazo[1,2-a]pyridines [PDF]

, 2015
Copper bromide catalyzed aerobic oxidative coupling of 2-aminopyridines with cinnamaldehydes directly led to the formation of 3-formyl-2-phenyl-imidazo[1,2-a]pyridines.
Bharate, Sandip B., Bharatam, Prasad V., Bharate, Jaideep B., Abbat, Sheenu, Vishwakarma, Ram A.   +4 more
core   +1 more source

Dimethyl‐, Diethyl‐, and Propylene Carbonates: An Emerging Class of Green Solvents for Organic Synthesis

The Chemical Record, Volume 26, Issue 8, August 2026.
This review highlights recent advances in the use of organic carbonates, dimethyl carbonate (DMC), diethyl carbonate (DEC), and propylene carbonate (PC), as solvents in organic synthesis. Based on over seventy studies from the past 6 years, it shows their application in different organic reaction types, emphasizing their role in safer and more ...
Gabriela T. Quadros, Livia C. L. Valente, Thiago Barcellos, Daniela Hartwig, Laura Abenante, Eder J. Lenardão   +5 more
wiley   +1 more source

Conversion of Pyridine to Imidazo[1,2‑a]pyridines by Copper-Catalyzed Aerobic Dehydrogenative Cyclization with Oxime Esters [PDF]

, 2016
A rapid and environmentally friendly conversion of pyridine to imidazo[1,2-a]pyridines has been developed via copper-catalyzed aerobic dehydrogenative cyclization with ketone oxime ...
Huawen Huang (1427662), Xiaodong Tang (252527), Xianwei Li (1426819), Xiaochen Ji (1771654), Min Zhang (111999), Huanfeng Jiang (1392913)   +5 more
core   +1 more source

Pyridyl‐Imidazopyridine Derivatives Displaying Submicromolar Activity Against Trypanosoma cruzi

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Previously reported pyridyl‐thiazoles and highly active imidazopyridines against Trypanosoma cruzi inspired the design of a new series of pyridyl‐substituted imidazopyridines. Among the synthesized compounds, 5h emerged as the most promising derivative, displaying potent trypanocidal activity (EC50 = 0.16 μM), excellent selectivity (SI > 1250), and ...
Ana Carolina Rocha Barreto, Kelly Lopes Figueira, Raquel Azevedo, Ketlym da Conceição, Ludmila de Ferreira de Almeida Fiuza, Luan dos Santos Vianna, Thiago Apolinário de Moraes, Wagner Alves de Souza Júdice, Maria de Nazaré Correia Soeiro, Jones Limberger   +9 more
wiley   +1 more source