Results 11 to 20 of about 1,977 (163)

Synthesis and applications of fused N- and O-heterocyclic systems from nitrodienic building-blocks [PDF]

, 2022
N-containing and O-containing heterocycles are widely distributed in natural products essential for life and are often responsible for the pharmaceutical activity of a lot of drugs and lead-compounds. Exploiting the electrophilic nature of functionalized
Benzi, Alice
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Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity [PDF]

, 2019
Twenty nine original 3-nitroimidazo[1,2-a]pyridine derivatives, bearing a phenylthio (or benzylthio) moiety at position 8 of the scaffold, were synthesized.
Azas, Nadine, Basmaciyan, Louise, Belle Mbou, Valère, Boudot, Clotilde, Bourgeade-Delmas, Sandra, Boutet-Robinet, Élisa, Casanova, Magali, Castera-Ducros, Caroline, Cohen, Anita, Courtioux, Bertrand, Fairlamb, Alan H., Fersing, Cyril, Hutter, Sébastien, Laget, Michèle, Milne, Rachel, Pedron, Julien, Piednoel, Mélanie, Primas, Nicolas, Rathelot, Pascal, Since, Marc, Sournia-Saquet, Alix, Valentin, Alexis, Vanelle, Patrice, Verhaeghe, Pierre, Wyllie, Susan   +24 more
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Silica-ZnCl 2 : An Efficient Catalyst for the Synthesis of 4-Methylcoumarins [PDF]

, 2013
Silica-ZnCl2 has been found to be an efficient and eco-friendly catalyst for the synthesis of substituted 4-methylcoumarins from ethyl acetoacetate and substituted phenols under “neat” conditions in an oil bath at 80°C.
Bandita Datta, ., De Luca, L., Mohamed Afzal Pasha, .   +2 more
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Deep Eutectic Solvents: The Organic Reaction Medium of the Century [PDF]

, 2016
This microreview summarizes the use of deep eutectic solvents (DESs) and related melts in organic synthesis. Solvents of this type combine the great advantages of other proposed environmentally benign alternative solvents, such as low toxicity, high ...
Abbott, Abbott, Abbott, Abbott, Abbott, Abbott, Abbott, Abo-Hamad, Amelio, Aparicio, Assanosi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Azizi, Bafti, Bakavoli, Beckman, Bednarz, Borse, Cao, Cardellini, Carriazo, Chahdoura, Chai, Chaskar, Chen, Chen, Constable, Cragg, Dai, Dai, Dai, Dai, Davey, De Oliveira Vigier, De Oliveira Vigier, De Santi, del Monte, Disale, Domínguez de María, Domínguez de María, Duan, Dupont, Durand, Díaz-Álvarez, Earle, Ferreira, Fischer, Francisco, Gambino, García, García-Verdugo, García-Álvarez, García-Álvarez, Gill, Gore, Gorke, Gu, Guajardo, Gupta, Hallet, Handy, Handy, Handy, Hari, Hawkins, Hayyan, Henderson, Hu, Hu, Ilgen, Ilgen, Imperato, Imperato, Imperato, Itoh, Jella, Jérôme, Karmakar, Kemeling, Keshavarzipour, Khandelwal, Krishnakumar, Kumar, Kus, Laird, Lavilla, Li, Li, Li, Li, Lindström, Liu, Liu, Liu, Lobo, Lobo, Lu, Macaev, Machida, Mahboub, Mallardo, Martins, Matsuda, Maugeri, Maugeri, Maugeri, Mobinikhaledi, Morales, More, Müller, Müller, Pace, Pal, Pandey, Patil, Pavia, Pawar, Pednekar, Pena-Pereira, Pena-Pereira, Peters, Phadtare, Phadtare, Pincock, Pérez, Pérez-Sánchez, Radošević, Rastogi, Reddy, Rodríguez-Álvarez, Ruß, Saberi, Sanap, Sanap, Santos, Sassone, Scholten, Serrano, Sheldon, Shuklov, Singh, Singh, Singh, Singh, Singh, Smith, Sonawane, Steinrück, Stepankova, Sunitha, Tanaka, Tang, Tang, Vidal, Vidal, Vidal, Wagle, Wang, Wang, Wang, Wang, Wang, Wang, Wasserscheid, Welton, Xia, Yadav, Yadav, Yadav, Yu, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhao   +192 more
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Imidazo[1,2-a]pyridine-based peptidomimetics as inhibitors of Akt [PDF]

Bioorganic & Medicinal Chemistry Letters, 2014
We report the design, synthesis, and biological evaluation of imidazopyridine-based peptidomimetics based on the substrate consensus sequence of Akt, an AGC family serine/threonine kinase hyperactivated in over 50% of human tumors. Our ligand-based approach led to the identification of novel substrate mimetic inhibitors of Akt1 featuring an unnatural ...
Young B, Kim, Chang Won, Kang, Sujeewa, Ranatunga, Hua, Yang, Said M, Sebti, Juan R, Del Valle   +5 more
openaire   +2 more sources

Cross-dehydrogenative coupling reaction using copper oxide impregnated on magnetite in deep eutectic solvents [PDF]

, 2016
The synthesis of different tetrahydroisoquinolines using choline chloride : ethylene glycol as a deep eutectic solvent (DES) and copper(II) oxide impregnated on magnetite as a catalyst has been accomplished successfully. The copper catalyst amount is the
Marset, Xavier, Pérez Galera, Juana María, Ramón, Diego J.   +2 more
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Oxidative Cross-Coupling of sp\u3csup\u3e3\u3c/sup\u3e- and sp\u3csup\u3e2\u3c/sup\u3e-Hybridized C–H Bonds: Vanadium-Catalyzed Aminomethylation of Imidazo[1,2-\u3ci\u3ea\u3c/i\u3e]pyridines [PDF]

, 2015
The vanadium-catalyzed oxidative coupling of substituted 2-arylimidiazo[1,2-a]pyridines to N-methylmorpholine oxide, which acts as both a coupling partner and an oxidant, has been achieved.
DeBoef, Brenton, Kaswan, Pinku, Kumar, Anil, Pericherla, Kasiviswanadharaju, Peters, Sean, Porter, Ashley, Simone, Marissa   +6 more
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PREPARATION OF NEW NITROGEN-BRIDGED HETEROCYCLES. 63. UNEXPECTED FORMATION OF THIENO[3 ',4 ':4,5]IMIDAZO[1,2-a]-PYRIDINES [PDF]

, 2008
The alkaline treatment and dehydrogenation of pyridinium salts, obtainable from the S-alkylation of 3,5-dimethylpyridinium 2-alkylthio-1-cyano2-thioxoethylides with some phenacyl bromides, afforded unexpected heterocycles, 3-alkylthio-1-arylcarbonyl-6,8 ...
Abe, T, Izumita, A, Kakehi, A, Suga, H   +3 more
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A Novel Solvent-free Approach to Imidazole containing Nitrogen-Bridgehead Heterocycles [PDF]

, 2013
A very simple domino reaction under solvent free conditions of various piridine-like heterocycles with 1,2-diaza-1,3-dienes produces in good yields imidazo[1,2-a]pyridines, imidazo[1,2-a]quinolines and imidazo[2,1-a]isoquinolines.
ATTANASI, ORAZIO ANTONIO, BIANCHI, LUCA, CAMPISI, LINDA ANTONELLA, DE CRESCENTINI, LUCIA, FAVI, GIANFRANCO, MANTELLINI, FABIO   +5 more
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In Situ Construction of Imidazopyridinium Fluorescent Labels for Bioconjugation

Angewandte Chemie International Edition, EarlyView.
Chromophore engineering of isoquinoline aldehydes generates TICT‐based fluorogenic dyes for in situ labeling of diverse (bio)molecules with large Stokes shifts compatible with cell imaging. ABSTRACT Simple, efficient transformations of fluorogenic nature that proceed under biocompatible conditions without the formation of byproducts are of high ...
Dongchen Du, László Albert, Milan Weitzel, Linda E. Eijsink, Elena R. Cotroneo, Dennis Marzin, Felipe Opazo, Nadja A. Simeth   +7 more
wiley   +1 more source