Results 41 to 50 of about 81,920,088 (158)

Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells. [PDF]

, 2008
Small molecules have been shown to be potent and selective probes to understand cell physiology. Here, we show that imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrimidines compose a class of compounds that target essential, conserved cellular processes ...
Andres Lopez, Lopez Andres, El Bali Brahim, Corey Nislow, Elke Ericson, Grant W. Brown, Brahim El Bali, Lisa Yu, Yu Lisa, Brown Grant W., Hamal Abdellah, Angus McQuibban, Guri Giaever, Abdellah Hamal, Heisler Lawrence E., Nislow Corey, Grant W Brown, Abderrahmane Anaflous, Boone Charles, Lawrence E. Heisler, Lawrence E Heisler, Ericson Elke, Charles Boone, Anaflous Abderrahmane, Giaever Guri, Mohammed Bellaoui, McQuibban Angus, Bellaoui Mohammed   +27 more
core   +1 more source

Synthesis of Triphenylamine-Imidazo[1,2-a]pyridine via Groebke–Blackburn–Bienaymé Reaction [PDF]

, 2020
A series of triphenylamine-imidazo[1,2-a]pyridine were synthesized in moderate yields (57–67%) by Groebke–Blackburn–Bienaymé reaction (GBBR) under catalyst and solvent green conditions.
Rocío Gámez-Montaño, Mahanandaiah Kurva, Manuel A. Rentería Gómez   +2 more
core   +1 more source

Design and Synthesis of Novel Imidazo[4,5‐c]pyridine Derivatives, Evaluation of Their Activity Against Hepatitis C Virus and In Silico Prediction of Their Binding Mode to NS4B Protein

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
A series of 18 novel imidazo[4,5‐c]pyridines was synthesized, and their anti‐HCV activity was evaluated. Compound 30b was identified as the most promising one, with EC50 = 6.61 µM. Molecular docking studies indicated the NS4B protein of the HCV as a potential target of these derivatives.
Eftychia Karampella, George Mpekoulis, Maria Georgiou, Iris Kolida, Katerina I. Kalliampakou, Eirini P. Kollia, Eleni V. Mikropoulou, Maria Halabalaki, Christos T. Chasapis, Niki Vassilaki, Nikolaos Lougiakis   +10 more
wiley   +1 more source

Integrative Insights Into DYRK1A From Molecular Function to Therapeutic Advancement

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
At the center the 3D structure of DYRK1A has been displayed. The dual‐function of DYRK1A involved in cancer and neurodegeneration, i.e., its overexpression drives Down syndrome, neurodegenerative disease etc., and underexpression causes intellectual disability, seizures, etc.
Sampriti Paul, Sonal Dubey, Prashant Tiwari   +2 more
wiley   +1 more source

Synthesis of imidazo[1,2-a] pyridines and imidazo[1,2-b] pyridazines tricyclic derivatives [PDF]

, 2009
Les motifs imidazo[1,2-a]pyridines et imidazo[1,2-b]pyridazines sont des noyaux très étudiés par la communauté scientifique, notamment dans le domaine thérapeutique.
Oudot, Romain
core  

I₂-Catalyzed intramolecular dehydrogenative aminooxygenation of alkynes to acylated imidazo[1,2-a]pyridines and indolizines [PDF]

, 2018
An efficient and green protocol for the construction of acylated imidazo[1,2-a]pyridines and indolizines via intramolecular dehydrogenative aminooxygenation of alkynes has been developed.
Yimiao He, Wenqing Yin, Chusheng Huang, Jianrong Huang, Chunfang Gan, Jian Wang, Fang Yang, Xinru Pang   +7 more
core   +1 more source

Peer review of the pesticide risk assessment of the active substance fluazaindolizine

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State, Malta, for the pesticide active substance fluazaindolizine.
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Athanasiou Dionysia, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Gabriella Fait, Franco Ferilli, German Giner Santonja, Varvara Gouliarmou, Alessio Ippolito, Frederique Istace, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Mariano Lopez Romano, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Silvia Mazzega, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza   +47 more
wiley   +1 more source

Electrophilic Iodination of Heterocyclic Compounds. Recent Advances 2008–2025: Part II

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
Electrophilic iodination using molecular iodine and iodide sources represents an efficient approach for accessing valuable iodinated organic compounds. This review highlights recent advances in the iodination of heterocyclic compounds from 2008 to 2025, emphasizing the role of heteroaryl iodides as important synthetic intermediates for biologically ...
Njomza Ajvazi, Stojan Stavber
wiley   +1 more source

Iodobenzene-catalyzed synthesis of Imidazo 1,2-a pyridines from aryl ketones with mCPBA in ionic liquid [PDF]

, 2010
[[abstract]]Iodobenzene-catalyzed synthesis of imidazo[1,2-a]pyridines from aryl ketones with mCPBA as a cooxidant in ionic liquid is described The method is simple, rapid and practical, generating Imidazo[1,2-a]pyridines from the aryl ketone without ...
Chang, YL;Wang, HM;Hou, RS;Kang, IJ;Chen, LC
core  

Tandem Flavin-Iodine-Catalyzed Aerobic Oxidative Sulfenylation of Imidazo[1,2-a]Pyridines with Thiols [PDF]

A green, aerobic sulfenylation of imidazo[ 1,2-a]pyridines was performed using thiols, a flavinand- iodine dual catalytic system, and environmentally benign molecular oxygen as the only sacrificial reagent.
Ohkado, Ryoma, Iida, Hiroki, Demizu, Ryuta   +2 more
core   +1 more source