Results 81 to 90 of about 4,314 (231)
Substituent-Dictated Concise Synthesis of 4,6-DisubstitutedN-Alkyl-2-pyridones and 2-Aminopyridines [PDF]
, 2005 Functionalized N-alkyl-2-pyridones and 2-aminopyridines are useful precursors for the synthesis of various heterocyclic compounds of therapeutic importance. In this paper we have delineated and illustrated a direct methodology for the synthesis of 6-aryl-
Goel, Atul +2 more
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The physiological basis of therapies for cerebellar ataxias
Therapeutic Advances in Neurological Disorders, 2016 Cerebellar ataxias represent a group of heterogeneous disorders impacting on activities of daily living and quality of life. Various therapies have been proposed to improve symptoms in cerebellar ataxias. This review examines the physiological background
Hiroshi Mitoma, Mario Manto
doaj +1 more source
Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes
The Journal of Physiology, EarlyView.Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve +11 more
wiley +1 more source
2-Aminopyridin-1-ium triiodide
Acta Crystallographica Section E, 2013 The asymmetric unit of the title compound, C5H7N2+.I3−, consists of one 2-aminopyridin-1-ium cation (apyH+) and one triiodide anion, both located in general postions. The apyH+ cation is planar within the experimental uncertainties.
Guido J. Reiss, Peer B. Leske
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The Journal of Physiology, EarlyView.Abstract figure legend The ultrarapid delayed rectifier potassium current (IKur) has long been considered an atrial‐specific current with no functional role in the ventricles, despite evidence of its expression in ventricular myocytes. In the present study we challenged this prevailing concept and investigated the potential role of IKur in ventricular ...
Alaa Amin E. Abdelmagid +17 more
wiley +1 more source
Convulsant actions of 4-aminopyridine on the guinea-pig olfactory cortex slice [PDF]
, 1982 The effects of bath-applied 4-aminopyridine on neurones and extracellular potassium and calcium concentrations were recorded in slices of guinea-pig olfactory cortex. Neurones were orthodromically activated by stimulating the lateral olfactory tract.
Ten Bruggencate, Gerrit +2 more
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GAA‐FGF14 Ataxia Is a Frequently Overlooked Cause of Sporadic Adult‐Onset Ataxia
Clinical Genetics, Volume 110, Issue 3, Page 358-362, September 2026.GAA‐FGF14 ataxia is a frequent cause of both familial and sporadic cerebellar ataxia. If symptoms are consistent, targeted testing of the FGF14 locus should be considered as a first‐line approach, as the diagnostic yield is up to 50%. ABSTRACT GAA‐FGF14 ataxia (spinocerebellar ataxia 27B, SCA27B), identified in 2023, is a major cause of adult‐onset ...
Eva‐Maria Kraus +7 more
wiley +1 more source
A spectroscopic study on ionization of 2-, 3- and 4-aminopyridines [PDF]
, 1999 The first ionization constants of the 2-, 3-, and 4-aminopyridines were evaluated by spectrophotometric methods using Evolving Factor Analysis approach. The ionization constants of aniline and pyridine were estimated by potentiometric methods in the same
CESARE MARINCOLA, FLAMINIA +5 more
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Molecular Mechanisms of Electric Signals Generated at Corneal Wounds
The FASEB Journal, Volume 40, Issue 16, 31 August 2026.Corneal injury triggers cell signaling (including calcium waves) leading to ion channel up‐regulation, increased ion pumping, and enhanced wound electric signals which stimulate wound healing. ABSTRACT Over 150 years ago, it was demonstrated that wounds produce electric fields and currents.
Brian Reid, Guillaume Luxardi, Min Zhao
wiley +1 more source
Synthesis of multi-substituted 4-aminopyridines via ring-opening and recyclization reactions of 2-iminopyridines [PDF]
, 2014 A novel synthesis of multi-substituted 4-aminopyridines from 2-iminopyridines by a two-step procedure is described. During this transformation, 4-amino-2-iminopyridines undergo a regioselective ring-opening reaction in the presence of KOH in t-butanol to
Liang,Yongjiu +6 more
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