Results 101 to 110 of about 10,137 (277)

Generalization of seizures parallels the formation of "dark" neurons in the hippocampus and pontine reticular formation after focal-cortical application of 4-aminopyridine (4-AP) in the rat. [PDF]

, 2008
Distribution and time course of the occurrence of "dark" neurons were compared with the EEG activity and behavior of rats during 4-aminopyridine (4-AP) induced epileptic seizures. A crystal of the K(+) channel blocker 4-AP (0.5 mg/kg) was placed onto the
Baracskay, P, Czurkó, A., Juhász, G, ORBAN, Gergely, Szepesi, Z   +4 more
core   +1 more source

Aminopyridines by Reilly readily available [PDF]

, 1974

openalex   +1 more source

Regioselective reactions of 3,4-pyridynes enabled by the aryne distortion model. [PDF]

, 2013
The pyridine heterocycle continues to play a vital role in the development of human medicines. More than 100 currently marketed drugs contain this privileged unit, which remains highly sought after synthetically. We report an efficient means to access di-
Garg, Neil K, Goetz, Adam E
core  

(β-D-ribofuranosyl)formamidine in the design and synthesis of 2-(β-D-ribofuranosyl)pyrimidines, including RF-containing derivatives [PDF]

, 2013
A wide range of novel 2-(β-D-ribofuranosyl)pyrimidines, including RF-containing derivatives, have been synthesized by the reaction of (β-D-ribofuranosyl)formamidine with various dielectrophilic substrates such as 3-alkoxy- and 3-chloro-1-(polyfluoroalkyl)
Adlington, Alvernhe, Böhm, Chu, De Las Heras, Druzhinin, Haas, Hagmann, Hiyama, Iaroshenko, Iaroshenko, Iaroshenko, Iaroshenko, Iaroshenko, Iaroshenko, Iaroshenko, Iaroshenko, Iaroshenko, Isanbor, Jeschke, Kirk, Klein, Kotljarov, Kotljarov, Li, Lin, Liu, Mewshaw, Müller, Nenajdenko, Pashkevich, Poonian, Poonian, Popov, Purser, Reetz, Resnati, Riley, Riley, Shah, Sosnovskikh, Sosnovskikh, Takagi, Tanaka, Tomashenko, Utimoto, Welch, Wójtowicz-Rajchel, Zanatta   +48 more
core   +1 more source

The inhibitory effects of iberiotoxin and 4‐aminopyridine on the relaxation induced by β₁‐ and β₂‐adrenoceptor activation in rat aortic rings [PDF]

, 1996
Nobuhiro Satake, Masahiro Shibata, Shoji Shibata   +2 more
openalex   +1 more source

Synthesis of 1,2,4-Triazolo[4,3-a]pyridines by I₂-Catalyzed Oxidative Coupling of 2-Aminopyridines with N-Tosylhydrazones [PDF]

, 2022
Yongxin Chen, Guo Xin, Liu Yafeng, Xueying Yang, Chen Baohua   +4 more
openalex   +1 more source

Physiological sharp wave-ripples and interictal events in vitro: What’s the difference? [PDF]

, 2014
Sharp wave-ripples and interictal events are physiological and pathological forms of transient high activity in the hippocampus with similar features.
Freund, Tamás, Gulyás, Attila, Karlócai, R. Mária, Kohus, Zsolt, Káli, Szabolcs, Máté, Zoltán, Szabó, Gábor, Ulbert, István   +7 more
core   +1 more source

Review: Current treatment of vestibular, ocular motor disorders and nystagmus

Therapeutic Advances in Neurological Disorders, 2009
Vertigo and dizziness are among the most common complaints with a lifetime prevalence of about 30%. The various forms of vestibular disorders can be treated with pharmacological therapy, physical therapy, psychotherapeutic measures or, rarely, surgery ...
Michael Strupp, Thomas Brandt
doaj   +1 more source

Theoretical Study on the Ortho–Para Reactivity Difference in Ru-Catalyzed Amination of Aminopyridines via η⁶-Coordination: Role of Meisenheimer Intermediate Coordination Ability

Inorganics
η6-Coordination catalysis has emerged as an effective strategy for activating electron-rich (hetero)arenes toward nucleophilic substitution. Recent experimental studies on Ru(II)-catalyzed amination of aminopyridines revealed a striking ortho–para ...
Cheng Wang, Shuo-Qing Zhang, Xin Hong
doaj   +1 more source

Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785

eLife
Voltage-gated K+ channels play central roles in human physiology, in health, and disease. A repertoire of inhibitors that are both potent and specific would, therefore, be of great value.
Shan Zhang, Robyn Stix, Esam A Orabi, Nathan Bernhardt, José D Faraldo-Gómez   +4 more
doaj   +1 more source