Results 101 to 110 of about 4,314 (231)

Structural diversity of different aminomethylpyridinium hexafluoridosilicates

Acta Chimica Slovenica
A series of new aminomethylpyridinium hexafluoridosilicate salts with the formula (RH)2[SiF6] (where R = 2-amino-3-methylpyridine (1), 2-amino-4-methylpyridine (2), 2-amino-5-methylpyridine (3) and 2-amino-6-methylpyridine (4)) were prepared by the ...
Andrej Pevec
doaj   +1 more source

Astrocytes in Genetic Epilepsies: Supporting Actor or Key Player?

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Astrocytes contribute to the pathophysiology of acquired epilepsy. However, less is known about their contribution to genetic epilepsy syndromes which often exhibit frequent comorbidity with neurodevelopmental and psychiatric disorders. Epileptic seizures are also frequently present in neurodevelopmental disorders.
Jenny Lange, Erica Zhao, Ellie O'Connell, Olivia Gillham, Amy McTague   +4 more
wiley   +1 more source

Structural basis for a p21‐activated kinase 4 and nicotinamide phosphoribosyltransferase dual inhibitor

Acta Crystallographica Section D, Volume 82, Issue 8, Page 972-981, August 2026.
The 2‐aminopyridine moiety of KPT‐7523 binds p21‐activated kinase 4 and nicotinamide phosphoribosyltransferase, enabling a versatile design for multi‐target cancer therapy.Simultaneous inhibition of oncogenic signaling and metabolic pathways represents a promising approach for cancer therapy.
Jaehui Park, Hye Rim Hong, Sang Hyun Han, Jinsue Song, Se-Young Son, Saehae Choi, Sang Mi Park, Won-Kyu Lee, Chimari Jiko, Ji-Hun Kim, Jun-Goo Jee, Jeong Kyu Bang, Il Yeong Park, Soo Jae Lee   +13 more
wiley   +1 more source

Gβγ subunit activation of KV7 and BKCa channels underlies calcitonin gene‐related peptide vasorelaxation in myogenic rat coronary resistance arteries

British Journal of Pharmacology, Volume 183, Issue 16, Page 5018-5032, August 2026.
Abstract Background and Purpose CGRP is a potent, clinically relevant coronary vasodilator known to play a role in cardioprotection. Here, we investigated the precise intracellular signalling pathways leading to vasodilation in small coronary arteries.
Lucy A. Donovan, JinHeng Lin, Milind Khashu, Christopher J. Garland, Kim A. Dora   +4 more
wiley   +1 more source

Ce(iii)-catalyzed highly efficient synthesis of pyridyl benzamides from aminopyridines and nitroolefins without external oxidants [PDF]

, 2018
An efficient Ce(iii)-catalyzed synthesis of amides and oxazolo[4,5-b]pyridines from 2-aminopyridines and nitroolefins via CC bond cleavage has been developed.
Pei Liang, Yiping Qian, Min Ye, Botao Liu, Zhengwang Chen, Xiaowei Wen   +5 more
core   +1 more source

Recent Advances in Conjugation Chemistry Expanding the Applications of the DNA Tetrahedron

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
The tetrahedral DNA nanostructure (TDN) is a promising drug delivery and biosensing platform that can be chemically modified with absolute payload precision. This review highlights explicit conjugation chemistries driving functionalization of the TDN for a broad range of applications, advancing its role in support of next‐generation biomimetic ...
Tyler J. Rutherford, Christopher J. Wilds   +1 more
wiley   +1 more source

Access to 2-aminopyridines : compounds of great biological and chemical significance [PDF]

, 2011
2‐Aminopyridines are key structural cores of bioactive natural products, medicinally important compounds, and organic materials and thus, extremely valuable synthetic targets.
Frech, Christian M., Jeanne L. Bolliger, Oberholzer, Miriam, Bolliger, Jeanne L., Miriam Oberholzer, Christian M. Frech   +5 more
core   +1 more source

Polymer‐Derived Ceramics: A Materials Platform for Advanced Energy and Environmental Applications

Journal of the American Ceramic Society, Volume 109, Issue 8, August 2026.
Polymer‐derived ceramics (PDCs) represent a unique class of materials bridging polymer chemistry and ceramic science, perfectly suited for the design of advanced materials for current technological challenges of high societal impact particularly in energy and environmental domains.
Hippolyte Dory, Chrystelle Salameh, Philippe Miele   +2 more
wiley   +1 more source

Aminopyridines Correct Early Dysfunction and Delay Neurodegeneration in a Mouse Model of Spinocerebellar Ataxia Type 1 [PDF]

, 2011
The contribution of neuronal dysfunction to neurodegeneration is studied in a mouse model of spinocerebellar ataxia type 1 (SCA1) displaying impaired motor performance ahead of loss or atrophy of cerebellar Purkinje cells. Presymptomatic SCA1 mice show a
Pandolfo, Massimo, Raphael Hourez, Serge N. Schiffmann, de Kerchove d'Exaerde, Alban, David Orduz, Chéron, Guy, Hourez, Raphaël, Schiffmann, Serge N., Orduz Perez, David, Alban de Kerchove d'Exaerde, David Gall, Millard, Isabelle, Laurent Servais, Harry T. Orr, Orr, Harry T., Isabelle Millard, Servais, Laurent, Gall, David, Guy Cheron, Massimo Pandolfo   +19 more
core   +1 more source

Blebbistatin reduces calcium buffering in cardiomyocytes: Consequences for cellular electrophysiology

The Journal of Physiology, Volume 604, Issue 16, Page 6858-6871, 15 August 2026.
Abstract figure legend Blebbistatin reduces Ca2+ buffering in induced pluripotent stem cell‐derived atrial cardiomyocytes. Blebbistatin, a widely used excitation–contraction uncoupling agent, decreases calcium (Ca2+) buffer affinity (increased buffer dissociation constant), leading to elevated diastolic Ca2+ levels, increased sarcoplasmic reticulum Ca2+
Izzatullo Sobitov, Katharina Ritzenhoff, Marie Gaulrapp, Lea Becker, Aiste Liutkute, Fitzwilliam Seibertz, Funsho E. Fakuade, Fleur E. Mason, Niels Voigt   +8 more
wiley   +1 more source