Quantifying Plasmodium vivax radical cure efficacy: a modelling study integrating clinical trial data and transmission dynamics. [PDF]
Lancet Infect DisCiavarella C +4 more
europepmc +1 more source
Efficacy and safety of pyrotinib-based regimens in patients with HER2-positive stage III/IV breast cancer: a real-world retrospective study in China. [PDF]
PeerJZhi L, Huang L, Pang X, Wu Q, Lei Y.
europepmc +1 more source
[Resistance of falciparum malaria to 4-aminoquinolines].
Revista cubana de medicina tropical, 1985 R, Martínez Rodríguez +4 more
openaire +1 more source
Related searches:
Synthesis of Highly Functionalized 4‐Aminoquinolines
Angewandte Chemie International Edition, 2016AbstractA diverse set of highly substituted 4‐aminoquinolines was synthesized from ynamides, triflic anhydride, 2‐chloropyridine, and readily accessible amides in a mild one‐step procedure.
Tim Wezeman +3 more
openaire +3 more sources
4-Aminoquinoline-ferrocene Hybrids as Potential Antimalarials
Recent Patents on Anti-Infective Drug Discovery, 2020Background: Malaria is a deadly disease. It is mostly treated using 4- aminoquinoline derivatives such as chloroquine etc. because it is well-tolerated, displays low toxicity, and after administration, it is rapidly absorbed. The combination of 4-aminoquinoline with other classes of antimalarial drugs has been reported to be an effective approach for ...
Xhamla Nqoro, Blessing A. Aderibigbe
openaire +2 more sources
Three 4-aminoquinolines of antimalarial interest
Acta Crystallographica Section C Crystal Structure Communications, 2006The structures of three compounds with potential antimalarial activity are reported. In N,N-diethyl-N'-(7-iodoquinolin-4-yl)ethane-1,2-diamine, C15H20IN3, (I), the molecules are linked into ribbons by N-H...N and C-H...N hydrogen bonds. In N-(7-bromoquinolin-4-yl)-N',N'-diethylethane-1,2-diamine dihydrate, C15H20BrN3.2H2O, (II), two aminoquinoline ...
Susan A, Bourne +2 more
openaire +2 more sources
Synthesis of novel fluorinated 4-aminoquinoline derivatives
Tetrahedron Letters, 2005AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access the actual ChemInform Abstract, please click on HTML or PDF.
Maurice Medebielle +4 more
openaire +1 more source
Antiplasmodial activities of 4-aminoquinoline–statine compounds
Bioorganic & Medicinal Chemistry Letters, 2012We report the discovery of new potent inhibitors of the growth of Plasmodium falciparum chloroquine (CQ)-resistant W2 strain. These compounds were designed using the double drug approach by introducing a residue able to enhance the accumulation of plasmepsins inhibitors into the food vacuole.
N. Vaiana +11 more
openaire +2 more sources
4‐Aminoquinoline Derivatives as Potential Antileishmanial Agents
Chemical Biology & Drug Design, 2015The leishmanicidal activity of a series of 4‐aminoquinoline (AMQ) derivatives was assayed against Leishmania amazonensis. This activity against the intracellular parasite was found stronger than for L. amazonensis promastigotes. Neither compound was cytotoxic against macrophages.
Luciana M R, Antinarelli +6 more
openaire +2 more sources
Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline [PDF]
Bioorganic & Medicinal Chemistry Letters, 2008 Two pyrrolizidinylalkyl derivatives of 4-amino-7-chloroquinoline (MG2 and MG3) were prepared and tested in vitro against CQ-sensitive and CQ-resistant strains of Plasmodium falciparum and in vivo in a Plasmodium berghei mouse model of infection.
A. Sparatore +7 more
openaire +2 more sources