Results 1 to 10 of about 26,162 (241)

4-Aminoquinolines block heme iron reactivity and interfere with artemisinin action [PDF]

eLife
Artemisinin-based combination therapies (ACTs) remain the mainstay of treatment for Plasmodium falciparum malaria, despite reports of ACT treatment failure. ACTs consist of an artemisinin and a longer-lived partner drug, which is often a quinoline. Given
Melissa Rosenthal, Daniel E Goldberg
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Exploring a Water–Ethyl Acetate System for the Efficient Synthesis of 4‐Aryl Quinolines [PDF]

ChemistryOpen
Heterocyclic compounds, particularly aryl quinolines, are of paramount importance in pharmaceuticals, materials science, and agrochemicals owing to their diverse biological and physicochemical properties. However, traditional synthesis methods often rely
Mohammad Qandalee, Aliyeh Khajeh‐Khezri, Mohammad Alikarami, Silvia Izquierdo, Ignacio M. López‐Coca   +4 more
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Quinolines: the role of substitution site in antileishmanial activity [PDF]

Frontiers in Chemistry
Leishmaniasis is one of the most widespread parasitic diseases in the world, primarily affecting the poorest and most vulnerable populations. The development of new therapeutic agents that are more efficient, safe, and selective remains a challenge.
Orlando G. Elso, Guadalupe García Liñares   +1 more
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Fe-catalyzed efficient synthesis of 2,4- and 4-substituted quinolines via C(sp2)–C(sp2) bond scission of styrenes [PDF]

Beilstein Journal of Organic Chemistry
Herein, we report a highly efficient, environmentally benign protocol for the domino synthesis of 2,4-disubstituted and 4-substituted quinoline molecules.
Prafull A. Jagtap, Manish M. Petkar, Vaishnavi R. Sawant, Bhalchandra M. Bhanage   +3 more
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Are basic and lipophilic chain groups highly required in leishmanicidal quinolines to favor the phagolysosome accumulation? [PDF]

Frontiers in Chemistry
Angel H. Romero
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Hydrogen Storage: Thermodynamic Analysis of Alkyl-Quinolines and Alkyl-Pyridines as Potential Liquid Organic Hydrogen Carriers (LOHC)

Applied Sciences, 2021
The liquid organic hydrogen carriers (LOHC) are aromatic molecules, which can be considered as an attractive option for the storage and transport of hydrogen. A considerable amount of hydrogen up to 7–8% wt.
Sergey P. Verevkin, Sergey P. Safronov, Artemiy A. Samarov, Sergey V. Vostrikov   +3 more
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2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
In this study, different assortments of 2-arylquinolines and 2,6-diarylquinolines have been developed. Recently, we have developed a new series of 6,7-dimethoxy-4-alkoxy-2-arylquinolines as Topoisomerase I (TOP1) inhibitors with potent anticancer ...
Mostafa M. Elbadawi, Wagdy M. Eldehna, Amer Ali Abd El-Hafeez, Warda R. Somaa, Amgad Albohy, Sara T. Al-Rashood, Keli K. Agama, Eslam B. Elkaeed, Pradipta Ghosh, Yves Pommier, Manabu Abe   +10 more
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Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines

Frontiers in Chemistry, 2021
An efficient enantioselective NMR analysis of atropisomeric quinolines in the promotion of chiral phosphoric acid is described, in which a variety of racemic 4-aryl quinolines were well-recognized with up to 0.17 ppm ΔΔδ value.
Junlin Wan, Jun Jiang, Juan Li
doaj   +1 more source

Synthesis, delivery, and molecular docking of fused quinolines as inhibitor of Hepatitis A virus 3C proteinase

Scientific Reports, 2021
It is widely accepted that Hepatitis A virus (HAV) is responsible for liver failure and even death in older people and in people with other serious health issues; so, proposing new compounds with inhibitory activity can help to treated of these disease’s.
Mehrnaz Rafiei Jorshari, Manouchehr Mamaghani, Parivash Jahanshahi   +2 more
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Design, Synthesis and Antimicrobial Activities of Quinoline-Based FabZ Inhibitors as Promising Antimicrobial Drugs

Medical Sciences Forum, 2022
At present, antimicrobial resistance is one of the most significant public health challenges [...]
Laurie Bibens, Jean-Paul Becker, Nadine Lemaitre, François Peltier, Virginie Morel, Céline Damiani, Nicolas Taudon, Alexandra Dassonville-Klimpt, Pascal Sonnet   +8 more
doaj   +1 more source