Results 11 to 20 of about 19,883 (275)

Mechanochemical Single-Carbon Insertion into (Iso)quinolines [PDF]

Nature Communications
(Iso)quinolines are among the most common heterocycles in US Food and Drug Administration approved drugs, whereas benzoazepines are underrepresented in drug discovery libraries, primarily because of the lack of efficient preparation routes. Therefore, an
Chunxiu Jing, Fanchen Huang, Xiaotong Liang, Pan Gao, Qing Gao, Zhaojing Zheng, Hao Wei   +6 more
doaj   +2 more sources

Bioinspired Quinoline-2 Derivatives Based on the Natural Alkaloid 2-Phenylquinoline from Conchocarpus longifolius (A.St.-Hil.) Kallunki & Pirani: Pharmacological Evaluation of Their Gastroprotective Potential [PDF]

Molecules
The treatment of gastric ulcers based on antisecretory drugs is often associated with side effects and high recurrence rates, reinforcing the need for new therapeutic alternatives.
Sérgio Fallone de Andrade, Eduardo Breviglieri, Ivan Limachi, Luisa Mota da Silva, Thaise Boeing, Lincon Bordignon Somensi, Olov Sterner, Alberto Gimenez, Valdir Cechinel Filho   +8 more
doaj   +2 more sources

4-Aminoquinolines block heme iron reactivity and interfere with artemisinin action [PDF]

eLife
Artemisinin-based combination therapies (ACTs) remain the mainstay of treatment for Plasmodium falciparum malaria, despite reports of ACT treatment failure. ACTs consist of an artemisinin and a longer-lived partner drug, which is often a quinoline. Given
Melissa Rosenthal, Daniel E Goldberg
doaj   +2 more sources

Visible-Light-Induced Singlet Oxygen-Promoted Arylation and Alkylation of Quinoxalin-2(1H)-ones and Quinolines

Molecules
We report a green and efficient visible-light-driven method for the arylation and alkylation of quinoxalin-2(1H)-ones and quinolines. This catalyst-free process utilizes air as the oxidant, offering mild reaction conditions, environmental sustainability,
Renjun Tan, Hequn Yang, Min Jiang, Peijun Song   +3 more
doaj   +2 more sources

Hydrogen Storage: Thermodynamic Analysis of Alkyl-Quinolines and Alkyl-Pyridines as Potential Liquid Organic Hydrogen Carriers (LOHC)

Applied Sciences, 2021
The liquid organic hydrogen carriers (LOHC) are aromatic molecules, which can be considered as an attractive option for the storage and transport of hydrogen. A considerable amount of hydrogen up to 7–8% wt.
Sergey P. Verevkin, Sergey P. Safronov, Artemiy A. Samarov, Sergey V. Vostrikov   +3 more
doaj   +1 more source

2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
In this study, different assortments of 2-arylquinolines and 2,6-diarylquinolines have been developed. Recently, we have developed a new series of 6,7-dimethoxy-4-alkoxy-2-arylquinolines as Topoisomerase I (TOP1) inhibitors with potent anticancer ...
Mostafa M. Elbadawi, Wagdy M. Eldehna, Amer Ali Abd El-Hafeez, Warda R. Somaa, Amgad Albohy, Sara T. Al-Rashood, Keli K. Agama, Eslam B. Elkaeed, Pradipta Ghosh, Yves Pommier, Manabu Abe   +10 more
doaj   +1 more source

Photochemical Regiodivergent Functionalization of Quinolines with Aryl Ketones [PDF]

Advanced science
A photocatalytic system‐controlled approach enables regiodivergent C2‐ and C4‐functionalization of quinolines with aryl ketones by optimizing aryl thiol photocatalysts and formate reductants. Using ortho‐(isopropoxycarbonyl)thiophenol with excess formate facilitates C4‐dearomatization, yielding bridged 1,3‐oxazepanes. In contrast, meta‐(methoxycarbonyl)
Zhao Y, Zhang B, Guo X, Dong K, Wang Z, Wu L, Liu Q.   +6 more
europepmc   +2 more sources

Synthesis, delivery, and molecular docking of fused quinolines as inhibitor of Hepatitis A virus 3C proteinase

Scientific Reports, 2021
It is widely accepted that Hepatitis A virus (HAV) is responsible for liver failure and even death in older people and in people with other serious health issues; so, proposing new compounds with inhibitory activity can help to treated of these disease’s.
Mehrnaz Rafiei Jorshari, Manouchehr Mamaghani, Parivash Jahanshahi   +2 more
doaj   +1 more source

Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines

Frontiers in Chemistry, 2021
An efficient enantioselective NMR analysis of atropisomeric quinolines in the promotion of chiral phosphoric acid is described, in which a variety of racemic 4-aryl quinolines were well-recognized with up to 0.17 ppm ΔΔδ value.
Junlin Wan, Jun Jiang, Juan Li
doaj   +1 more source

Design, Synthesis and Antimicrobial Activities of Quinoline-Based FabZ Inhibitors as Promising Antimicrobial Drugs

Medical Sciences Forum, 2022
At present, antimicrobial resistance is one of the most significant public health challenges [...]
Laurie Bibens, Jean-Paul Becker, Nadine Lemaitre, François Peltier, Virginie Morel, Céline Damiani, Nicolas Taudon, Alexandra Dassonville-Klimpt, Pascal Sonnet   +8 more
doaj   +1 more source