Results 11 to 20 of about 26,162 (241)

Transition-metal-free approach to quinolines via direct oxidative cyclocondensation reaction of N,N-dimethyl enaminones with o-aminobenzyl alcohols

Frontiers in Chemistry, 2022
A transition-metal-free method for the construction of 3-substituted or 3,4-disubstituted quinolines from readily available N,N-dimethyl enaminones and o-aminobenzyl alcohols is reported.
Kairui Rao, Zhangmengjie Chai, Pan Zhou, Donghan Liu, Yulin Sun, Fuchao Yu   +5 more
doaj   +1 more source

Multi-Substituted Quinolines as HIV-1 Integrase Allosteric Inhibitors

Viruses, 2022
Allosteric HIV-1 integrase (IN) inhibitors, or ALLINIs, are a new class of antiviral agents that bind at the dimer interface of the IN, away from the enzymatic catalytic site and block viral replication by triggering an aberrant multimerization of the ...
Long Phi Dinh, Jian Sun, Courtney D. Glenn, Krunal Patel, Julie A. Pigza, Matthew G. Donahue, Larry Yet, Jacques J. Kessl   +7 more
doaj   +1 more source

Quinoline Functionalized Schiff Base Silver (I) Complexes: Interactions with Biomolecules and In Vitro Cytotoxicity, Antioxidant and Antimicrobial Activities

Molecules, 2021
A series of fifteen silver (I) quinoline complexes Q1–Q15 have been synthesized and studied for their biological activities. Q1–Q15 were synthesized from the reactions of quinolinyl Schiff base derivatives L1–L5 (obtained by condensing 2 ...
Adesola A. Adeleke, Sizwe J. Zamisa, Md. Shahidul Islam, Kolawole Olofinsan, Veronica F. Salau, Chunderika Mocktar, Bernard Omondi   +6 more
doaj   +1 more source

Iron-catalyzed indolo[2,3-c]quinoline synthesis from nitroarenes and benzylic alcohols/aldehydes promoted by elemental sulfur

Green Synthesis and Catalysis, 2022
An iron-catalyzed strategy for the rapid synthesis of indolo[2,3-c]quinolines has been developed. This cascade reaction involving alcohol oxidation, nitro reduction, and oxidative annulation was achieved in a one-pot.
Rong Li, Shuxin Jiang, Haolin Zheng, Hanwen Lei, Zhi Huang, Shanping Chen, Guo-Jun Deng   +6 more
doaj   +1 more source

Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids [PDF]

, 2020
This is the pre-peer reviewed version of the following article: Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids, which has been published in final form at https://doi.org/10.1002/slct.201903835.
Carda, Miguel, Cardona G, Wilson I, Coa, Juan Carlos, Conesa Milián, Laura, Robledo, Sara M., Upegui Zapata, Yulieth Alexandra, Yepes, Andrés   +6 more
core   +1 more source

In Silico Study of Coumarins and Quinolines Derivatives as Potent Inhibitors of SARS-CoV-2 Main Protease

Frontiers in Chemistry, 2021
The pandemic that started in Wuhan (China) in 2019 has caused a large number of deaths, and infected people around the world due to the absence of effective therapy against coronavirus 2 of the severe acute respiratory syndrome (SARS-CoV-2).
Osvaldo Yañez, Osvaldo Yañez, Osvaldo Yañez, Manuel Isaías Osorio, Manuel Isaías Osorio, Eugenio Uriarte, Eugenio Uriarte, Carlos Areche, William Tiznado, José M. Pérez-Donoso, Olimpo García-Beltrán, Fernando González-Nilo   +11 more
doaj   +1 more source

A Convenient One-Pot Preparation of 2-Methyl-3-(phenylthio- methyl)quinolines from Morita-Baylis-Hillman Adducts and Their Oxidation to the Corresponding Sulfones

Molecules, 2012
A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl)quinolines from Morita-Baylis-Hillman adducts via conjugate addition of thiols followed by reductive cyclization with Fe/AcOH was developed. The 2-methyl-3-(phenylthiomethyl)quinolines were
Ching-Fa Yao, Veerababurao Kavala, Chintakunta Ramesh, Po-Min Lei, Chun-Wei Kuo   +4 more
doaj   +1 more source

Controlled partial transfer hydrogenation of quinolines by cobalt-amido cooperative catalysis

Nature Communications, 2020
Controlling the partial reduction of quinolines is challenging, given the competing overreduction to tetrahydroquinolines. Here, the authors report a cobalt-amido cooperative catalyst for the selective, partial transfer hydrogenation of quinolines to 1,2-
Maofu Pang, Jia-Yi Chen, Shengjie Zhang, Rong-Zhen Liao, Chen-Ho Tung, Wenguang Wang   +5 more
doaj   +1 more source

Asymmetric addition of chiral boron-ate complexes to cyclic iminium ions [PDF]

, 2014
Boron-ate complexes derived from enantioenriched secondary benzylic boronic esters and aryl lithiums have been reacted with quinolinium, pyridinium and dihydroisoquinolinium salts to give enantioenriched heterocyclic structures with very high ...
Aggarwal, Varinder K., Feeney, Katie M J, Leonori, Daniele, Mohiti, Maziar, Rampalakos, Konstantinos   +4 more
core   +2 more sources

Intramolecular Imino Diels-Alder Reaction: Progress toward the Synthesis of Uncialamycin [PDF]

, 2009
We herein described an intramolecular imino Diels-Alder reaction promoted with BF3.OEt2/DDQ affording substituted quinolines. Using this procedure, we prepared the chiral quitioline moiety of the uncialamycin, a new enediyne natural ...
Desrat, S, van de Weghe, P
core   +3 more sources