Results 31 to 40 of about 19,386 (276)
Beilstein Journal of Organic Chemistry, 2013 Meta- or para-nitro-(pentafluorosulfonyl)benzenes underwent the Davis reaction with arylacetonitriles to provide the SF5-containing benzisoxazoles. Good yields were obtained with arylacetonitriles containing the electron-neutral or electron-donor group ...
Petr Beier, Tereza Pastýříková
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Pharmaceutics, 2022 Hybrid-based drugs linked through a transition metal constitute an emerging concept for Plasmodium intervention. To advance the drug design concept and enhance the therapeutic potential of this class of drugs, we developed a novel hybrid composed of ...
Caroline De Souza Pereira +14 more
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Angewandte Chemie, EarlyView.Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang +1 more
wiley +2 more sources
Evolution of PIKK family kinase inhibitors: A new age cancer therapeutics
Frontiers in Bioscience-Landmark, 2020 Phosphatidylinositol-3 kinase-related kinases (PIKKs) belong to a family of atypical serine/threonine kinases in humans. They actively participate in a diverse set of cellular functions such as meiotic, V(D)J recombination, chromosome maintenance, DNA ...
Althaf Shaik, Sivapriya Kirubakaran
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Synthesis and Antimycobacterial Evaluation of N-(4-(Benzyloxy)benzyl)-4-aminoquinolines
Molecules, 2022 Tuberculosis remains a global health problem that affects millions of people around the world. Despite recent efforts in drug development, new alternatives are required.
Estevão Silveira Grams +13 more
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Asymmetric hydrogenation of quinolines activated by Bronsted acids
, 2010 Enantioselective hydrogenation of quinolines and quinoxalines catalyzed by iridium/diphosphine complex with catalytic amount of Bronsted acid as activator was developed.
Wang, Duo-Sheng +2 more
core +1 more source
Angewandte Chemie, EarlyView.A new mode of the palladium/norbornene (Pd/NBE) cooperative catalysis, that is, redox‐neutral difunctionalization of aryl boronic esters with two electrophiles, has been developed, which can be used to streamline the preparation of a functionalized benzoazepane.
Rong Ye +4 more
wiley +2 more sources
Newer Synthetic Approaches for the Disubstituted Quinolines from Aryl Amines [PDF]
, 2022 Supervisor: Khan, Abu TalebThe thesis entitled “Newer Synthetic Approaches for the Disubstituted Quinolines from Aryl Amines” describes the synthesis of 2,3- and 2,4-disubstituted quinoline derivatives.
Ali, Saghir
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Acta Pharmaceutica, 2016 As a part of ongoing studies in developing new anticancer agents, novel 1,2-dihydropyridine 4, thienopyridine 5, isoquinolines 6–20, acrylamide 21, thiazolidine 22, thiazoles 23–29 and thiophenes 33–35 bearing a biologically active quinoline nucleus were
Ghorab Mostafa M. +5 more
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Angewandte Chemie, EarlyView.An iron‐photocatalyzed unsymmetrical 1,2‐hetero(atom)difunctionalization of alkenes enables to install orthogonal C–Cl and C–O (alkoxyamine) handles which provides access to diverse nucleophiles via complementary reactivity (SN and photoredox) at two distinct sites. Detailed mechanistic studies elucidate interesting features of the iron catalytic cycle.
Amrita Chaudhuri +5 more
wiley +2 more sources