Results 1 to 10 of about 38,082 (231)

Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides.

PLoS Biology, 2009
Despite more than 25 years of research, the molecular targets of quinoline-3-carboxamides have been elusive although these compounds are currently in Phase II and III development for treatment of autoimmune/inflammatory diseases in humans.
Per Björk, Anders Björk, Thomas Vogl, Martin Stenström, David Liberg, Anders Olsson, Johannes Roth, Fredrik Ivars, Tomas Leanderson   +8 more
doaj   +1 more source

Synthesis of antioxidant and antimicrobial bioactive compounds based on the quinoline-hydrazone and benzimidazole structure

Journal of Advanced Pharmaceutical Technology & Research, 2023
Quinoline and its derivatives are known to have various biological activities such as antibacterial and antioxidant. Therefore, this study aims to synthesize quinoline moiety from isatin and ethyl acetoacetate by Pfitzinger reaction under acidic ...
Antonius Herry Cahyana, Devin Halim, Laely Amaliyah   +2 more
doaj   +1 more source

Recent advances in functionalized quinoline scaffolds and hybrids—Exceptional pharmacophore in therapeutic medicine

Frontiers in Chemistry, 2023
Quinoline is one of the most common nitrogen-containing heterocycles owing to its fascinating pharmacological properties and synthetic value in organic and pharmaceutical chemistry.
Oluwadunni F. Elebiju, Oluwadunni F. Elebiju, Olayinka O. Ajani, Olayinka O. Ajani, Gbolahan O. Oduselu, Gbolahan O. Oduselu, Temitope A. Ogunnupebi, Temitope A. Ogunnupebi, Ezekiel Adebiyi, Ezekiel Adebiyi, Ezekiel Adebiyi   +10 more
doaj   +1 more source

Hydrogen-Bonding Interactions in Luminescent Quinoline-Triazoles with Dominant 1D Crystals

Molecules, 2017
Quinoline-triazoles 2-((4-(diethoxymethyl)-1H-1,2,3-triazol-1-yl)methyl)quinoline (1), 2-((4-(m-tolyl)-1H-1,2,3-triazol-1-yl)methyl)quinoline (2) and 2-((4-(p-tolyl)-1H-1,2,3-triazol-1-yl)methyl)quinoline (3) have been prepared with CuAAC click reactions
Shi-Qiang Bai, David James Young, T. S. Andy Hor   +2 more
doaj   +1 more source

SYNTHESIS OF CERTAIN NOVEL PYRIDOTHIOPYRANOQUINOLINES AS POTENTIAL ANTICANCER AGENTS

Zagazig Journal of Pharmaceutical Sciences, 2006
A series of ethyl 2-substituted aminopyrido [3',2': 5,6] thiopyrano [ 4,3,2-de] quinoline-1-carboxylate (VII)i-viii was obtained by reacting ethyl2-chloropyrido[3',2':5,6] thiopyrano [4,3,2-de] quinoline-1-carboxylate (VIa) with certain aromatic amines ...
Khaled El-Shemy , Osama El-Badry , Sameha Roshdy , Mervat El-Enany , Mohamed Ismail   +4 more
doaj   +1 more source

Ultrasonic treated sludge for accelerating quinoline biodegradation

上海师范大学学报. 自然科学版, 2018
In this work,ultrasound was used for treating sludge,and released organics was used as electron donors for accelerating quinoline biodegradation.Flask experimental results showed that quinoline removal rates are proportional to the biomass of treated and
Wang Youke, Zhang Yuting, Lu Qinyuan, Zhang Chenyuan, Zhang Yongming   +4 more
doaj   +1 more source

A review on quinoline hydrazone derivatives as a new class of potent antitubercular and anticancer agents

Beni-Suef University Journal of Basic and Applied Sciences, 2017
Tuberculosis (TB) and Cancer remains a global public health problem in recent years. There is an urgent need for the screening of new bioactive molecules with new targets and with a different mechanism of action.
Mustapha C. Mandewale, Udaysinha C. Patil, Supriya V. Shedge, Uttam R. Dappadwad, Ramesh S. Yamgar   +4 more
doaj   +1 more source

Synthesis and in-vitro studies of some new quinoline 1,3,4-thiadiazolo pyrimidin derivatives

Bulletin of the Chemical Society of Ethiopia, 2017
A series of eight new quinoline associated 1,3,4-thiadiazolo pyrimidin derivatives (5a-h) have been developed using 4-amino-8-fluoro-quinoline-3-carboxylic acid ethyl ester (1) as raw material and by involving 8-fluoro-4-methylsulfanylthiocarbonylamino ...
K. K. Valluri,, I. V. K. Viswanath, P. V. V. S. Naga Raju, B. Rajasekher, B. R. Dasu   +4 more
doaj   +1 more source

Quinoline-Based Molecules Targeting c-Met, EGF, and VEGF Receptors and the Proteins Involved in Related Carcinogenic Pathways

Molecules, 2020
The quinoline ring system has long been known as a versatile nucleus in the design and synthesis of biologically active compounds. Currently, more than one hundred quinoline compounds have been approved in therapy as antimicrobial, local anaesthetic ...
Annamaria Martorana, Gabriele La Monica, Antonino Lauria   +2 more
doaj   +1 more source

2-Azidobenzaldehyde-Based [4+2] Annulation for the Synthesis of Quinoline Derivatives

Molecules
Quinoline is a privileged heterocyclic ring which can be found in many drug molecules and bioactive compounds. The development of synthetic methods for making quinoline derivatives continuously attracts the interest of organic and medicinal chemists ...
Xiaofeng Zhang, Miao Liu, Weiqi Qiu, Wei Zhang   +3 more
doaj   +1 more source