Broad susceptibility of Candida auris strains to 8-hydroxyquinolines and mechanisms of resistance [PDF]
mBio, 2023 The fungal pathogen Candida auris represents a severe threat to hospitalized patients. Its resistance to multiple classes of antifungal drugs and ability to spread and resist decontamination in healthcare settings make it especially dangerous.
Matthew B. Lohse +7 more
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Synthesis of 4-Hydroxyquinolines as Potential Cytotoxic Agents. [PDF]
Int J Mol Sci, 2022 The synthesis of alkyl 2-(4-hydroxyquinolin-2-yl) acetates and 1-phenyl-4-(phenylamino)pyridine-2,6(1H,3H)-dione was optimised. Starting from 4-hydroxyquinolines (4HQs), aminomethylation was carried out via the modified Mannich reaction (mMr) applying ...
Csuvik O +3 more
europepmc +4 more sources
Synthesis of Bioactive Aminomethylated 8-Hydroxyquinolines via the Modified Mannich Reaction. [PDF]
Int J Mol Sci, 2023 8-hydroxyquinoline (oxine) is a widely known and frequently used chelating agent, and the pharmacological effects of the core molecule and its derivatives have been studied since the 19th century.
Csuvik O, Szatmári I.
europepmc +4 more sources
Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines
Molecules, 2020 Compounds containing the 8-hydroxyquinoline (8-HQ) 1 nucleus exhibit a wide range of biological activities, including antimicrobial, anticancer, and antifungal effects.
Haythem A. Saadeh +2 more
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Molecules, 2021 Methyl-substituted 8-hydroxyquinolines (Hquin) were successfully used to synthetize five-coordinated oxovanadium(IV) complexes: [VO(2,6-(Me)2-quin)2] (1), [VO(2,5-(Me)2-quin)2] (2) and [VO(2-Me-quin)2] (3).
Joanna Palion-Gazda +13 more
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Correction: Saadeh et al. Recent Advances in the Synthesis and Biological Activity of 8-Hydroxyquinolines. Molecules 2020, 25, 4321 [PDF]
Molecules, 2022 The author wishes to make the following correction to this paper [...]
Haythem A. Saadeh +2 more
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New insights into the mechanism of antifungal action of 8-hydroxyquinolines
Saudi Pharmaceutical Journal, 2019 The 8-hydroxyquinoline core is a privileged scaffold for drug design explored to afford novel derivatives endowed with biological activity. Our research aimed at clarifying the antifungal mechanism of action of clioquinol, 8-hydroxy-5-quinolinesulfonic ...
Bruna Pippi +9 more
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Optimization of Zinc and Aluminum Hydroxyquinolines for Applications as Semiconductors in Molecular Electronics [PDF]
MoleculesThis work explores the dispersed heterojunction of tris-(8-hydroxyquinoline) aluminum (AlQ3) and 8-hydroxyquinoline zinc (ZnQ2) with tetracyanoquinodimethane (TCNQ) and 2,6-diaminoanthraquinone (DAAq).
María Elena Sánchez Vergara +5 more
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Synthesis and biological characterization of organoruthenium complexes with 8-hydroxyquinolines [PDF]
Journal of Inorganic Biochemistry, 2018 In this study we report the synthesis, characterization and a thorough biological evaluation of twelve organoruthenium–8-hydroxyquinolinato (Ru-hq) complexes. The chosen hqH ligands bear various halogen atoms in different positions which enables to study
Bai, Yang +7 more
core +7 more sources
A [3+3] Aldol-SNAr-Dehydration Approach to 2-Naphthol and 7-Hydroxyquinoline Derivatives [PDF]
MoleculesA one-pot [3+3] aldol-SNAr-dehydration annulation sequence was utilized to fuse hindered phenols onto aromatic substrates. The transformation joins doubly activated 1,3-disubstituted acetone derivatives (dinucleophiles) with C5-activated 2 ...
Kwabena Fobi +2 more
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