mBio, 2019 A defining characteristic of treating tuberculosis is the need for prolonged administration of multiple drugs. This may be due in part to subpopulations of slowly replicating or nonreplicating Mycobacterium tuberculosis bacilli exhibiting phenotypic ...
Landys Lopez Quezada +23 more
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Resonance raman characterization of the forms of ground-state 8-substituted 7-hydroxyquinoline caged acetate compounds in aqueous solutions [PDF]
, 2010 Monday Poster Session: Resonance Raman in Biological and Chemical Systems (MP22) - Poster Number: 0978-substituted 7-hydroxyquinolines, like 8-chloro-7-hydroxyquinoline (CHQ) and 8-cyano-7-hydroxyquinoline (CyHQ), are able to be useful for 1PE and 2PE ...
An, H +5 more
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Clioquinol synergistically augments rescue by zinc supplementation in a mouse model of acrodermatitis enteropathica. [PDF]
PLoS ONE, 2013 BackgroundZinc deficiency due to poor nutrition or genetic mutations in zinc transporters is a global health problem and approaches to providing effective dietary zinc supplementation while avoiding potential toxic side effects are needed.Methods ...
Jim Geiser +5 more
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Dihydropyrimidine-thiones and clioquinol synergize to target beta-amyloid cellular pathologies through a metal-dependent mechanism [PDF]
, 2017 The lack of therapies for neurodegenerative diseases arises from our incomplete understanding of their underlying cellular toxicities and the limited number of predictive model systems.
Barrasa, M. Inmaculada +9 more
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Solution Chemistry of Copper(II) Binding to Substituted 8-Hydroxyquinolines.
Inorganic Chemistry, 2020 8-Hydroxyquinolines (8HQs) are a family of lipophilic metal ion chelators that have been used in a range of analytical and pharmaceutical applications over the last 100 years. More recently, CQ (clioquinol; 5-chloro-7-iodo-8-hydroxyquinoline) and PBT2 (5,
Kelly L. Summers +9 more
semanticscholar +1 more source
Investigating the Activity Spectrum for Ring-Substituted 8-Hydroxyquinolines
Molecules, 2010 In this study, a series of fourteen ring-substituted 8-hydroxyquinoline derivatives were prepared. The synthesis procedures are presented. The compounds were analyzed using RP-HPLC to determine lipophilicity.
Aidan Coffey +10 more
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Syntheses, transformations and applications of aminonaphthol derivatives prepared via modified Mannich reactions [PDF]
, 2013 A special alteration is the three-component modi fi ed Mannich reaction (mMR), in which formaldehyde is replaced by an aromatic aldehyde, the secondary amine by ammonia, and the C e H acid by an electron-rich aromatic compound such as 1- or 2 ...
Fülöp, Ferenc, Szatmári, István
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Two-Metal Ion-Dependent Enzymes as Potential Antiviral Targets in Human Herpesviruses
mBio, 2022 The majority of drug discovery efforts against herpesviruses have focused on nucleoside analogs that target viral DNA polymerases, agents that are associated with dose-limiting toxicity and/or a narrow spectrum of activity.
Katherine A. DiScipio +6 more
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Antimalarial and antimicrobial activities of 8-aminoquinoline-uracils metal complexes [PDF]
, 2016 8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and ...
Kunwittaya, Sarun +6 more
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Tạp chí Khoa học Đại học Huế: Khoa học Tự nhiên, 2020 In this work, a theoretical study for platinum(II)-8-hydroxyquinoline-tetrylene complexes [{PtCl–C9H6NO}–NHEPh] (Pt–EPh) is carried out for the first time by using the density functional theory (DFT).
Huynh Thi Phuong Loan +2 more
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