Results 11 to 20 of about 14,689 (241)

2-Alkyl-4-hydroxyquinolines from a Marine-Derived Streptomyces sp. Inhibit Hyphal Growth Induction in Candida albicans

Marine Drugs, 2019
Four 2-alkyl-4-hydroxyquinoline derivatives (1⁻4) were isolated from a semisolid rice culture of the marine-derived actinomycete Streptomyces sp. MBTG13.
Heegyu Kim, Ji-Yeon Hwang, Beomkoo Chung, Eunji Cho, Suhyun Bae, Jongheon Shin, Ki-Bong Oh   +6 more
doaj   +2 more sources

8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications

Drug Design, Development and Therapy, 2013
Veda Prachayasittikul,1 Supaluk Prachayasittikul,2 Somsak Ruchirawat,3 Virapong Prachayasittikul11Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, 2Center of Data Mining and Biomedical Informatics, Faculty of ...
Prachayasittikul V, Prachayasittikul S, Ruchirawat S, Prachayasittikul V   +3 more
doaj   +2 more sources

Stabilization of nontoxic Ajβ-oligomers: Insights into the mechanism of action of hydroxyquinolines in alzheimer’s disease [PDF]

Journal of Neuroscience, 2015
©2015 the authors. The extracellular accumulation of amyloid β (A/β) peptides is characteristic of Alzheimer's disease (AD). However, formation of diffusible, oligomeric forms of Aβ, both on and off pathways to amyloid fibrils, is thought to include ...
Adlard, PA, Barnham, KJ, Curtain, CC, Doble, PA, Hare, DJ, Hinds, MG, Kirb, N, Li, QX, Lind, M, Masters, CL, McColl, G, Mertens, HDT, Pham, CLL, Roberts, AM, Roberts, BR, Ryan, TM   +15 more
core   +3 more sources

HIF-Dependent NFATC1 Activation Upregulates ITGA5 and PLAUR in Intestinal Epithelium in Inflammatory Bowel Disease

Frontiers in Genetics, 2021
Intestinal epithelial cells exist in physiological hypoxia, leading to hypoxia-inducible factor (HIF) activation and supporting barrier function and cell metabolism of the intestinal epithelium.
Evgeny Knyazev, Diana Maltseva, Maria Raygorodskaya, Maxim Shkurnikov, Maxim Shkurnikov, Maxim Shkurnikov   +5 more
doaj   +1 more source

Toluene Dioxygenase-Catalyzed cis-Dihydroxylation of Quinolines: A Molecular Docking Study and Chemoenzymatic Synthesis of Quinoline Arene Oxides

Frontiers in Bioengineering and Biotechnology, 2021
Molecular docking studies of quinoline and 2-chloroquinoline substrates at the active site of toluene dioxygenase (TDO), were conducted using Autodock Vina, to identify novel edge-to-face interactions and to rationalize the observed stereoselective cis ...
Derek R. Boyd, Narain D. Sharma, Pui L. Loke, Jonathan G. Carroll, Paul J. Stevenson, Patrick Hoering, Christopher C. R. Allen   +6 more
doaj   +1 more source

Effect of 8-hydroxyquinoline and derivatives on human neuroblastoma SH-SY5Y cells under high glucose [PDF]

PeerJ, 2016
8-Hydroxyquinoline and derivatives exhibit multifunctional properties, including antioxidant, antineurodegenerative, anticancer, anti-inflammatory and antidiabetic activities.
Wilasinee Suwanjang, Supaluk Prachayasittikul, Virapong Prachayasittikul   +2 more
doaj   +2 more sources

Synthesis and Antimicrobial Activity of Novel Substituted Ethyl 2-(Quinolin-4-yl)-propanoates

Molecules, 2013
Substituted 4-hydroxyquinolines were synthesized from anilines and diethyl 2-(ethoxymethylene)malonate by the Gould-Jacobs reaction via cyclization of the intermediate anilinomethylenemalonate followed by hydrolysis and decarboxylation.
Yong Zhou, Kim Drummond Rainsford, Keith Miller, M. Akram Khan   +3 more
doaj   +1 more source

PBT2 acts through a different mechanism of action than other 8-hydroxyquinolines: an X-ray fluorescence imaging study.

Metallomics, 2020
8-Hydroxyquinolines (8HQs) comprise a family of metal-binding compounds that have been used or tested for use in numerous medicinal applications, including as treatments for bacterial infection, Alzheimer's disease, and cancer. Two key 8HQs, CQ (5-chloro-
K. Summers, N. Dolgova, K. Gagnon, George J. Sopasis, Ashley K. James, B. Lai, N. Sylvain, H. Harris, H. Nichol, G. George, I. Pickering   +10 more
semanticscholar   +1 more source

In-Out Surface Modification of Halloysite Nanotubes (HNTs) for Excellent Cure of Epoxy: Chemistry and Kinetics Modeling

Nanomaterials, 2021
In-out surface modification of halloysite nanotubes (HNTs) has been successfully performed by taking advantage of 8-hydroxyquinolines in the lumen of HNTs and precisely synthesized aniline oligomers (AO) of different lengths (tri- and pentamer) anchored ...
Shahab Moghari, Seyed Hassan Jafari, Mohsen Khodadadi Yazdi, Maryam Jouyandeh, Aleksander Hejna, Payam Zarrintaj, Mohammad Reza Saeb   +6 more
doaj   +1 more source

Selective biochlorination of hydroxyquinolines by a flavin-dependent halogenase

Tetrahedron Letters, 2016
Jixun Zhan
exaly   +2 more sources