Results 31 to 40 of about 82,349 (282)
Beni-Suef University Journal of Basic and Applied Sciences, 2017 Tuberculosis (TB) and Cancer remains a global public health problem in recent years. There is an urgent need for the screening of new bioactive molecules with new targets and with a different mechanism of action.
Mustapha C. Mandewale +4 more
doaj +1 more source
Synthesis and in-vitro studies of some new quinoline 1,3,4-thiadiazolo pyrimidin derivatives
Bulletin of the Chemical Society of Ethiopia, 2017 A series of eight new quinoline associated 1,3,4-thiadiazolo pyrimidin derivatives (5a-h) have been developed using 4-amino-8-fluoro-quinoline-3-carboxylic acid ethyl ester (1) as raw material and by involving 8-fluoro-4-methylsulfanylthiocarbonylamino ...
K. K. Valluri, +4 more
doaj +1 more source
Molecules, 2020 The quinoline ring system has long been known as a versatile nucleus in the design and synthesis of biologically active compounds. Currently, more than one hundred quinoline compounds have been approved in therapy as antimicrobial, local anaesthetic ...
Annamaria Martorana +2 more
doaj +1 more source
First-principles simulations of the initial phase of self-aggregation of a cyanine dye: structure and optical spectra [PDF]
, 2014 Using first-principles simulations, we investigated the initial steps of the self-aggregation of the dye pseudoisocyanine (PIC) in water. First, we performed molecular dynamics (MD) simulations of the self-aggregation process, in which pile-of-coins ...
Haverkort, Frank +2 more
core +2 more sources
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, EarlyView.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
How cinchona alkaloid-derived primary amines control asymmetric electrophilic fluorination of cyclic ketones. [PDF]
, 2014 The origin of selectivity in the α-fluorination of cyclic ketones catalyzed by cinchona alkaloid-derived primary amines is determined with density functional calculations.
Houk, KN, Lam, Yu-hong
core +2 more sources
Quinoline-2-carbonitrile [PDF]
Acta Crystallographica Section E Structure Reports Online, 2010 In the title compound, C(10)H(6)N(2), the mol-ecule is almost planar, with an r.m.s. desviation of 0.014 Å. The dihedral angle between the aromatic rings is 1.28 (16)°. In the crystal, mol-ecules are stacked along the axis by way of weak aromatic π-π stacking inter-actions between the benzene and pyridine rings of adjacent mol-ecules [centroid-centroid
Wan-Sin Loh +3 more
openaire +3 more sources
Diazo Transfer From Nitrous Oxide Employing Phosphorus Ylides
Angewandte Chemie, EarlyView.A phosphorus ylide‐mediated strategy achieves the direct fixation of nitrous oxide (N2O) to access diazo compounds, which after intra‐ or intermolecular trapping, afford N2‐containing organic building blocks. This approach provides an alternative to hazardous diazo‐transfer reagents and establishes N2O fixation as a sustainable methodology.
Jhen‐Kuei Yu +4 more
wiley +2 more sources
A novel 18F-labelled high affinity agent for PET imaging of the translocator protein [PDF]
, 2015 The translocator protein (TSPO) is an important target for imaging focal neuroinflammation in diseases such as brain cancer, stroke and neurodegeneration, but current tracers for non-invasive imaging of TSPO have important limitations.
Adele Blair +8 more
core +1 more source
Acta Crystallographica Section E Structure Reports Online, 2013 In the title compound, C9H8N2O2S, the sulfamoyl -NH2 group is involved in inter-molecular hydrogen bonding with the sulfonamide O and quinoline N atoms. In the crystal, mol-ecules are linked into dimers via pairs of N-H⋯N hydrogen bonds, forming an R 2 (2)(10) motif.
Joachim Kusz +3 more
openaire +3 more sources