Results 151 to 160 of about 4,514 (173)

QSAR Models for Anti-Malarial Activity of 4-Aminoquinolines

Current Computer Aided-Drug Design, 2014
In the present study, predictive quantitative structure - activity relationship (QSAR) models for anti-malarial activity of 4-aminoquinolines have been developed. CORAL, which is freely available on internet (http://www.insilico.eu/coral), has been used as a tool of QSAR analysis to establish statistically robust QSAR model of anti-malarial activity of
Vijay H, Masand, Andrey A, Toropov, Alla P, Toropova, Devidas T, Mahajan   +3 more
openaire   +2 more sources

4-Aminoquinoline Based Molecular Hybrids as Antimalarials: An Overview

Current Topics in Medicinal Chemistry, 2014
In recent times, the novel concept of generating hybrid molecules by pharmacophoric hybridisation approach is fast becoming an alternative to other existing strategies of drug development. These hybrids also known as 'dual drugs' or 'double drugs' are especially found to be effective in overcoming drug resistance problems.
Sunny, Manohar, Mohit, Tripathi, Diwan S, Rawat   +2 more
openaire   +2 more sources

ChemInform Abstract: 4‐Aminoquinolines. A General Approach

ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
F. PALACIOS, D. APARICIO, G. RUBIALES, A. M. O. DE RETANA, E. M. DE MARIGORTA   +4 more
openaire   +1 more source

Electrophilic Tropylation of Aminopyridines and 4-Aminoquinoline

Russian Journal of General Chemistry, 2019
The reactions of 2-, 3-, 4-aminopyridines or 4-aminoquinoline with hydrolytically stable tropylium salts (perchlorate or tetrafluoroborate) have afforded N-(1′-cyclohepta-2′,4′,6′-trienyl)-2-aminopyridine, N-(1′-cyclohepta-2′,4′,6′-trienyl)-3-aminopyridine, N-(1′-cyclohepta-2′,4′, 6′-trienyl)-4-aminopyridine, and N-(1′-cyclohepta-2′,4′,6′-trienyl)-4 ...
L. P. Yunnikova, Yu. E. Likhareva, V. V. Esenbaeva   +2 more
openaire   +1 more source

Quinolines VI. Some 4-Aminoquinoline Derivatives

Journal of the American Chemical Society, 1948
E A, STECK, L L, HALLOCK, C M, SUTER
openaire   +2 more sources

Synthesis of β-carboline/4-aminoquinoline hybrids

2022
Naturally occurring β-carboline alkaloids (e.g., harmine) exhibit a wide range of biological activities, including anticancer [1]. The antimalarials chloroquine (CQ) and mefloquine (MQ) belong to the class of 4-substituted quinolines. Their anticancer properties are also well documented.
Pavić, Kristina, Poje, Goran, Rajić, Zrinka   +2 more
openaire   +1 more source

[Lewis acids mediated synthesis of 4-aminoquinolines].

Acta cientifica venezolana, 2000
The synthesis of 4-amino-2-quinolines from N-phenylcyanoacetamides and of 4-aminoquinolines from 2-aminobenzonitrile and beta-dicarbonylic compounds was accomplished using Lewis acids as catalysts.
G, Cabrera, C, Márquez
openaire   +1 more source

Some 7-Substituted 4-Aminoquinoline Derivatives

Journal of the American Chemical Society, 1946
A R, SURREY, H F, HAMMER
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4-Aminoquinolines

1984
E. W. McChesney, C. D. Fitch
openaire   +1 more source

[Potential harms associated with 4-aminoquinoline treatment].

Lakartidningen, 2020
Hydroxychloroquine and chloroquine are currently being evaluated as treatment against COVID-19. These drugs are associated with some potential harms, including QTc-interval prolongation, hypoglycaemia, severe skin reactions and psychiatric effects. Use of hydroxychloroquine or chloroquine should be reserved to current indications or clinical trials, as
openaire   +1 more source