Assessment of molecular markers for anti-malarial drug resistance after the introduction and scale-up of malaria control interventions in western Kenya [PDF]
, 2015 Background Although it is well known that drug pressure selects for drug-resistant parasites, the role of transmission reduction by insecticide-treated bed nets (ITNs) on drug resistance remains unclear.
Gatei, Wangeci +14 more
core +3 more sources
G-quadruplex DNA motifs in the malaria parasite Plasmodium falciparum and their potential as novel antimalarial drug targets [PDF]
, 2018 G-quadruplexes are DNA or RNA secondary structures that can be formed from guanine-rich nucleic acids. These four-stranded structures, composed of stacked quartets of guanine bases, can be highly stable and have been demonstrated to occur in vivo in the ...
Damblon, C +7 more
core +1 more source
Alternatively spliced transcripts and novel pseudogenes of the Plasmodium falciparum resistance-associated locus pfcrt detected in East African malaria patients. [PDF]
, 2014 OBJECTIVES: Polymorphisms in the lysosomal transporter encoded by the pfcrt gene directly impact on Plasmodium falciparum susceptibility to aminoquinolines.
Adam, Ishag +13 more
core +4 more sources
Revista do Instituto de Medicina Tropical de São Paulo, 1991 Field studies in the western Amazon region (state of Acre, Brazil) indicate that the 4-aminoquinolines, as well as the combined regimen with sulfadoxine-pyrimethamine, can no longer be recomended for the treatment and prophylaxis of P.
S. Neifer, P.G. Kremsner
doaj +1 more source
Synthesis and reactions of aminopropenes, which contains functional groups [PDF]
, 2013 В рамках данной работы осуществлен синтез енаминов, содержащих остатки первичных, вторичных, третичных аминов, а также амидную и тиоамидную группы. Проведено комплексное исследование структуры полученных соединений с помощью спектральных методов, включая
Lugovik, K. I., Луговик, К. И.
core
In Silico Screening of Potential Allicin Compound From Allium Sativum as Antiplasmodium [PDF]
, 2015 Allicin compound (2-propene-1- sulphinothioat acid S-2-propenyl ester) is known to have potential as antiplasmodium in vitro. However, the inhibitory activity mechanism of Allicin to plasmodium is still unknown.
Fatmawaty, F. (Fatmawaty) +3 more
core
, 2007 The synthesis and antimalarial activity of a novel series of first generation 4-aminoquinoline-containing 2,4,5-trisubstituted aminoxazoles against two strains of the Plasmodium falciparum parasite in vitro is described.
Chibale, Kelly +3 more
core +1 more source
Cymantrene, Cyrhetrene and Ferrocene Nucleobase Conjugates: Synthesis, Structure, Computational Study, Electrochemistry and Antitrypanosomal Activity [PDF]
, 2017 A series of cymantrene- and cyrhetrene-nucleobase derivatives together with the ferrocene-adenine conjugates have been prepared and characterized. The key step in synthesis of all compounds involved an N1-regioselective Michael addition of the respective
Alecu +62 more
core +1 more source
Quantifying the Evolution and Impact of Antimalarial Drug Resistance: Drug Use, Spread of Resistance, and Drug Failure over a 12-Year Period in Papua New Guinea [PDF]
, 2017 Background. Antimalarial use is a key factor driving drug resistance and reduced treatment effectiveness in Plasmodium falciparum malaria, but there are few formal, quantitative analyses of this process. Methods.
Baea, Kay +11 more
core
4-Aminoquinolines modulate RNA structure and function: Pharmacophore implications of a conformationally restricted polyamine. [PDF]
Biochem Biophys Res Commun, 2023 Hossain MI +5 more
europepmc +1 more source