Variation of the Chloroquine Resistance Transporter (Crt) Gene in Chloroquine-Resistant and Chloroquine-Sensitive Plasmodium berghei [PDF]
Iranian Journal of Parasitology, 2008 Background: The emergence and spread of chloroquine resistant Plasmodium falciparum in the world stimulated some investigators to consider different aspects of chloroquine resistance in human and rodent Plasmodia.
N Ghobakhloo +5 more
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Interactions between 4-aminoquinoline and heme: Promising mechanism against Trypanosoma cruzi
International Journal for Parasitology: Drugs and Drug Resistance, 2016 Chagas disease is a neglected tropical disease caused by the flagellated protozoan Trypanosoma cruzi. The current drugs used to treat this disease have limited efficacy and produce severe side effects. Quinolines, nitrogen heterocycle compounds that form
Guilherme Curty Lechuga +9 more
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4-aminoquinolines: An Overview of Antimalarial Chemotherapy
Medicinal chemistry, 2016 Malaria is a major health problem and Plasmodium falciparum strain resistance to existing antimalarials drugs made the current approach inadequate for treatment of malaria. Drug development directed against malaria is generally targeting blood schizonts.
Shreekant Deshpande, Bhimanna Kuppast
openaire +1 more source
Chloroquine Analog Interaction with C2- and Iota-Toxin in Vitro and in Living Cells
Toxins, 2016 C2-toxin from Clostridium botulinum and Iota-toxin from Clostridium perfringens belong both to the binary A-B-type of toxins consisting of two separately secreted components, an enzymatic subunit A and a binding component B that facilitates the entry of ...
Angelika Kronhardt +3 more
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Revista da Sociedade Brasileira de Medicina Tropical, 1985 Através da prova de 7 dias foi estudado o grau de resistência do Plasmodium falciparum à cloroquina, amodiaquina e sulfadoxina-pirimetamina em Porto Velho, Estado de Rondônia, Brasil.
Santiago Reyes +2 more
doaj
Variation in Glucose-6-Phosphate Dehydrogenase activity following acute malaria
PLoS Neglected Tropical Diseases, 2022 Primaquine and tafenoquine are the only licensed drugs with activity against Plasmodium vivax hypnozoites but cause haemolysis in patients with glucose–6–phosphate dehydrogenase (G6PD) deficiency.
Benedikt Ley +14 more
doaj
Iranian Journal of Public Health, 2013 Drug resistance in malaria parasites is extending in the world particularly in chemical synthesized drugs such as 4- aminoquinolines and aminoalcoholes. Employing herbal extracts is encouraged by WHO in the malarious areas.
Masomeh Khodadadi +6 more
doaj +2 more sources
Effect of Crocus sativus Stigma (saffron) alone or in combination with chloroquine on chloroquine sensitive strain of Plasmodium berghei in mice [PDF]
Journal of HerbMed Pharmacology, 2015 Introduction: In malaria treatment protocols, treatment failure or drug resistance of synthesized drugs like alkaloids related to quinine, and aminoquinolines are the main problems now.
Pestechian Nader +3 more
doaj
Malaria and the traveller [PDF]
, 2005 Malaria has reached epidemic proportions. About 40% of the world’s population live in malarious areas. It is estimated that 400 million people are infected by malaria each year and of these, 1-3 million die, mostly children under five years of age.
Tonna, Antonella, Tonna, Ivan
core
Design, synthesis, heme binding and density functional theory studies of isoindoline-dione-4-aminoquinolines as potential antiplasmodials. [PDF]
Future Med Chem, 2020 Rani A +7 more
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